Gene polymorphisms in patients with type 2 diabetes and diabetic nephropathy
Aconsiderablevariabilityintheincidenceandprevalenceofdiabeticnephropathy(DN)cohereswithanimportantcontributionofmultigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressu...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10.02.2012
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| In: |
Central European journal of biology
Year: 2012, Volume: 7, Issue: 2, Pages: 210-219 |
| ISSN: | 1644-3632 |
| DOI: | 10.2478/s11535-012-0003-x |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.2478/s11535-012-0003-x Verlag, Volltext: http://www.degruyterbrill.com/view/j/biol.2012.7.issue-2/s11535-012-0003-x/s11535-012-0003-x.xml 
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| Author Notes: | Hana Demova, Jana Boleckova, Daniela Rose, Hannes Koeppel, Bohumir Prochazka, Ludmila Brunerova, Ivan Rychlik, Marie Cerna |
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| 520 | |a Aconsiderablevariabilityintheincidenceandprevalenceofdiabeticnephropathy(DN)cohereswithanimportantcontributionofmultigenetic predisposition in the development of DN. Some genes, which probably participate in the pathogenesis of diabetic nephropathy, also play a role in the regulation of blood pressure, familial hyperlipidemia, familial hypertension and other diseases of the cardiovascular system. We have examined the association of diabetic nephropathy, nephropathy of non-diabetic origin, hypertension and of type 2 diabetes itself with several genetic polymorphisms (the insertion/deletion polymorphism in the gene for angiotensin-converting enzyme, the G/T polymorphism in the glucose transpor ter 1 gene, the G/T (894) polymorphism and the T/C (-786) polymorphism in the eNOS gene in three groups of patients with diabetes mellitus: 1) patients without diabetic nephropathy (DM); 2) patients with DN; 3) patients with nephropathy of non-diabetic origin (NDRD). Angiotensin-converting enzyme is an important factor in a development of arterial hypertension, but in our groups of Central European diabetic patients the I/D polymorphism was not associated with diabetic nephropathy. Furthermore, we have confirmed that the T/C (T786C) polymorphism in the eNOS gene is associated with metabolic syndrome including type 2 diabetes. | ||
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