Highly enantioselective copper-catalyzed electrophilic trifluoromethylation of β-ketoesters
Enantioselective Cu-catalyzed trifluoromethylation of β-ketoesters using commercially available trifluoromethylating reagents is reported. A number of αCF3 β-ketoesters are obtained with up to 99% ee. The trifluoromethylated products were then transformed diastereoselectively to α-CF3 β-hydroxyesters w...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 13, 2012
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| In: |
Journal of the American Chemical Society
Year: 2012, Volume: 134, Issue: 26, Pages: 10769-10772 |
| ISSN: | 1520-5126 |
| DOI: | 10.1021/ja3039773 |
| Online Access: | Verlag, Volltext: http://dx.doi.org/10.1021/ja3039773 Verlag, Volltext: http://pubs.acs.org/doi/10.1021/ja3039773 
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| Author Notes: | Qing-Hai Deng, Hubert Wadepohl, and Lutz H. Gade |
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| 520 | |a Enantioselective Cu-catalyzed trifluoromethylation of β-ketoesters using commercially available trifluoromethylating reagents is reported. A number of αCF3 β-ketoesters are obtained with up to 99% ee. The trifluoromethylated products were then transformed diastereoselectively to α-CF3 β-hydroxyesters with two adjacent quaternary stereocenters via a Grignard reaction. | ||
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