Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products
Many transplantation centers routinely collect 1 or more autologous peripheral blood stem cell (PBSC) grafts in patients with hemato-oncologic and autoimmune disorders. However, subsequent high-dose chemotherapy and autologous blood stem cell transplantation (ABSCT) are often not performed, for vari...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
|
| In: |
Biology of blood and marrow transplantation
Year: 2019, Jahrgang: 25, Heft: 2, Pages: 382-390 |
| ISSN: | 1523-6536 |
| DOI: | 10.1016/j.bbmt.2018.09.013 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1016/j.bbmt.2018.09.013 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1083879118305706 
|
| Verfasserangaben: | Katharina Kriegsmann, Maurizio Wack, Petra Pavel, Anita Schmitt, Mark Kriegsmann, Thomas Bruckner, Carsten Müller-Tidow, Patrick Wuchter |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1588178692 | ||
| 003 | DE-627 | ||
| 005 | 20240528111734.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190227s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.bbmt.2018.09.013 |2 doi | |
| 035 | |a (DE-627)1588178692 | ||
| 035 | |a (DE-576)518178692 | ||
| 035 | |a (DE-599)BSZ518178692 | ||
| 035 | |a (OCoLC)1341040097 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Kriegsmann, Katharina |d 1986- |e VerfasserIn |0 (DE-588)1049422449 |0 (DE-627)781924006 |0 (DE-576)40339774X |4 aut | |
| 245 | 1 | 0 | |a Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products |c Katharina Kriegsmann, Maurizio Wack, Petra Pavel, Anita Schmitt, Mark Kriegsmann, Thomas Bruckner, Carsten Müller-Tidow, Patrick Wuchter |
| 264 | 1 | |c 2019 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Available online 20 September 2018 | ||
| 500 | |a Gesehen am 27.02.2019 | ||
| 520 | |a Many transplantation centers routinely collect 1 or more autologous peripheral blood stem cell (PBSC) grafts in patients with hemato-oncologic and autoimmune disorders. However, subsequent high-dose chemotherapy and autologous blood stem cell transplantation (ABSCT) are often not performed, for various reasons. Currently, little is known about the actual utilization rate of stored PBSCs. We retrospectively analyzed the collection, storage, and disposal practices of PBSC products from a large cohort of patients (n=1020) with hematologic, oncologic, and autoimmune disorders at our institution over a 12-year period. Patients with multiple myeloma were excluded. Based on our institution-specific charges, we estimated the costs for PBSC collection/processing and storage. The median number of sufficient PBSC collections per patient in the whole cohort was 2 (range, 1 to 6). We could demonstrate that only 67% of all patients who had collected sufficient PBSCs for transplantation actually underwent ABSCT, and only a small minority of all patients (4%) underwent multiple ABSCTs. The actual use of the stored PBSC grafts varied among disease entities from >80% to 0%. From a retrospective standpoint, the collected and discarded (definitively not used) or stored (potentially not used) cryostored PBSCs were associated with considerable costs of collection, cryopreservation, and long-term cryostorage. Although keeping open the therapeutic option for future transplantations may be important, there is currently a huge discrepancy between collection/storage practices and actual utilization of the cryopreserved PBSCs, at a considerable cost and strain on patients. Our study provides a rationale for reevaluating the present standards. | ||
| 650 | 4 | |a Autologous transplantation | |
| 650 | 4 | |a Cost evaluation | |
| 650 | 4 | |a Cryostorage | |
| 650 | 4 | |a PBSC | |
| 700 | 1 | |a Schmitt, Anita |d 1969- |e VerfasserIn |0 (DE-588)141722495 |0 (DE-627)630587752 |0 (DE-576)325593892 |4 aut | |
| 700 | 1 | |a Kriegsmann, Mark |d 1987- |e VerfasserIn |0 (DE-588)103740324X |0 (DE-627)755668782 |0 (DE-576)39141870X |4 aut | |
| 700 | 1 | |a Bruckner, Thomas |d 1956- |e VerfasserIn |0 (DE-588)136046215 |0 (DE-627)574429298 |0 (DE-576)300798768 |4 aut | |
| 700 | 1 | |a Müller-Tidow, Carsten |d 1968- |e VerfasserIn |0 (DE-588)1015101798 |0 (DE-627)705330230 |0 (DE-576)351197893 |4 aut | |
| 700 | 1 | |a Wuchter, Patrick |d 1975- |e VerfasserIn |0 (DE-588)123450284 |0 (DE-627)082563624 |0 (DE-576)184642574 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biology of blood and marrow transplantation |d [Erscheinungsort nicht ermittelbar] : Elsevier Health Sciences, 1998 |g 25(2019), 2, Seite 382-390 |h Online-Ressource |w (DE-627)334374782 |w (DE-600)2057605-5 |w (DE-576)118352229 |x 1523-6536 |7 nnas |a Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products |
| 773 | 1 | 8 | |g volume:25 |g year:2019 |g number:2 |g pages:382-390 |g extent:9 |a Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.bbmt.2018.09.013 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/article/pii/S1083879118305706 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190227 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 123450284 |a Wuchter, Patrick |m 123450284:Wuchter, Patrick |d 60000 |d 63500 |e 60000PW123450284 |e 63500PW123450284 |k 0/60000/ |k 1/60000/63500/ |p 8 |y j | ||
| 998 | |g 1015101798 |a Müller-Tidow, Carsten |m 1015101798:Müller-Tidow, Carsten |d 910000 |d 910100 |e 910000PM1015101798 |e 910100PM1015101798 |k 0/910000/ |k 1/910000/910100/ |p 7 | ||
| 998 | |g 136046215 |a Bruckner, Thomas |m 136046215:Bruckner, Thomas |d 910000 |d 999701 |e 910000PB136046215 |e 999701PB136046215 |k 0/910000/ |k 1/910000/999701/ |p 6 | ||
| 998 | |g 103740324X |a Kriegsmann, Mark |m 103740324X:Kriegsmann, Mark |d 910000 |d 912000 |e 910000PK103740324X |e 912000PK103740324X |k 0/910000/ |k 1/910000/912000/ |p 5 | ||
| 998 | |g 141722495 |a Schmitt, Anita |m 141722495:Schmitt, Anita |d 910000 |d 910100 |e 910000PS141722495 |e 910100PS141722495 |k 0/910000/ |k 1/910000/910100/ | ||
| 998 | |g 1049422449 |a Kriegsmann, Katharina |m 1049422449:Kriegsmann, Katharina |d 910000 |d 910100 |e 910000PK1049422449 |e 910100PK1049422449 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1588178692 |e 305684066X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"2019","dateIssuedKey":"2019"}],"relHost":[{"titleAlt":[{"title":"BBMT"}],"pubHistory":["Volume 4, issue 1 (June 1998)-Volume 26, issue 12 (December 2020)"],"id":{"zdb":["2057605-5"],"eki":["334374782"],"issn":["1523-6536"]},"part":{"year":"2019","volume":"25","pages":"382-390","issue":"2","text":"25(2019), 2, Seite 382-390","extent":"9"},"recId":"334374782","physDesc":[{"extent":"Online-Ressource"}],"disp":"Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell productsBiology of blood and marrow transplantation","origin":[{"publisher":"Elsevier Health Sciences ; Carden Jennings","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; Charlottesville, Va.","dateIssuedDisp":"[1998-2020]"}],"title":[{"subtitle":"BBMT ; the official journal of the American Society for Blood and Marrow Transplantation","title":"Biology of blood and marrow transplantation","title_sort":"Biology of blood and marrow transplantation"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"note":["Gesehen am 16.03.2021"]}],"person":[{"role":"aut","given":"Katharina","family":"Kriegsmann","display":"Kriegsmann, Katharina"},{"display":"Schmitt, Anita","family":"Schmitt","role":"aut","given":"Anita"},{"display":"Kriegsmann, Mark","family":"Kriegsmann","given":"Mark","role":"aut"},{"display":"Bruckner, Thomas","given":"Thomas","role":"aut","family":"Bruckner"},{"family":"Müller-Tidow","role":"aut","given":"Carsten","display":"Müller-Tidow, Carsten"},{"role":"aut","given":"Patrick","family":"Wuchter","display":"Wuchter, Patrick"}],"title":[{"title":"Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products","title_sort":"Collection, cryostorage, transplantation, and disposal of hematopoietic stem cell products"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"note":["Available online 20 September 2018","Gesehen am 27.02.2019"],"recId":"1588178692","physDesc":[{"extent":"9 S."}],"name":{"displayForm":["Katharina Kriegsmann, Maurizio Wack, Petra Pavel, Anita Schmitt, Mark Kriegsmann, Thomas Bruckner, Carsten Müller-Tidow, Patrick Wuchter"]},"id":{"eki":["1588178692"],"doi":["10.1016/j.bbmt.2018.09.013"]}} | ||
| SRT | |a KRIEGSMANNCOLLECTION2019 | ||