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The combination of Benzaldehyde and Nickel‐catalyzed photoredox C(sp3)-H alkylation/arylation

Herein we report a highly selective photoredox C(sp3)−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3)−H alkylation/arylation of ethers. A sele...

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Main Authors: Zhang, Lumin (Author) , Si, Xiaojia (Author) , Yang, Yangyang (Author) , Zimmer, Marc (Author) , Witzel, Sina (Author) , Sekine, Kohei (Author) , Rudolph, Matthias (Author) , Hashmi, A. Stephen K. (Author)
Format: Article (Journal)
Language:German
Published: January 9, 2019
In: Angewandte Chemie. International edition
Year: 2019, Volume: 58, Issue: 6, Pages: 1823-1827
ISSN:1521-3773
DOI:10.1002/anie.201810526
Online Access:Resolving-System, Volltext: http://dx.doi.org/10.1002/anie.201810526
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/anie.201810526
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Author Notes:Lumin Zhang, Xiaojia Si, Yangyang Yang, Marc Zimmer, Sina Witzel, Kohei Sekine, Matthias Rudolph, and A. Stephen K. Hashmi
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Summary:Herein we report a highly selective photoredox C(sp3)−H alkylation/arylation of ethers through the combination of a photo‐organocatalyst (benzaldehyde) and a transition‐metal catalyst (nickel). This method provides a simple and general strategy for the C(sp3)−H alkylation/arylation of ethers. A selective late‐stage modification of (−)‐ambroxide has also been conducted to demonstrate the applicability of the method.
Item Description:Accepted manuscript online: November 12, 2018
Gesehen am 01.03.2019
Physical Description:Online Resource
ISSN:1521-3773
DOI:10.1002/anie.201810526

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