Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health
Recent studies have demonstrated that repeated short‐term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 May 2016
|
| In: |
EMBO molecular medicine
Year: 2016, Jahrgang: 8, Heft: 6, Pages: 654-669 |
| ISSN: | 1757-4684 |
| DOI: | 10.15252/emmm.201505801 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.15252/emmm.201505801 Verlag, Volltext: http://embomolmed.embopress.org/content/8/6/654 
|
| Verfasserangaben: | Jessica Fuhrmeister, Annika Zota, Tjeerd P. Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M. de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G. Okun, Stephan Herzig and Adam J. Rose |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1588269493 | ||
| 003 | DE-627 | ||
| 005 | 20220815114904.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190301s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.15252/emmm.201505801 |2 doi | |
| 035 | |a (DE-627)1588269493 | ||
| 035 | |a (DE-576)518269493 | ||
| 035 | |a (DE-599)BSZ518269493 | ||
| 035 | |a (OCoLC)1341040805 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Fuhrmeister, Jessica |e VerfasserIn |0 (DE-588)1071497456 |0 (DE-627)825950635 |0 (DE-576)433113820 |4 aut | |
| 245 | 1 | 0 | |a Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health |c Jessica Fuhrmeister, Annika Zota, Tjeerd P. Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M. de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G. Okun, Stephan Herzig and Adam J. Rose |
| 246 | 3 | 3 | |a Fasting‐induced liver GADD45 beta restrains hepatic fatty acid uptake and improves metabolic health |
| 264 | 1 | |c 3 May 2016 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.03.2019 | ||
| 520 | |a Recent studies have demonstrated that repeated short‐term nutrient withdrawal (i.e. fasting) has pleiotropic actions to promote organismal health and longevity. Despite this, the molecular physiological mechanisms by which fasting is protective against metabolic disease are largely unknown. Here, we show that, metabolic control, particularly systemic and liver lipid metabolism, is aberrantly regulated in the fasted state in mouse models of metabolic dysfunction. Liver transcript assays between lean/healthy and obese/diabetic mice in fasted and fed states uncovered “growth arrest and DNA damage‐inducible” GADD45β as a dysregulated gene transcript during fasting in several models of metabolic dysfunction including ageing, obesity/pre‐diabetes and type 2 diabetes, in both mice and humans. Using whole‐body knockout mice as well as liver/hepatocyte‐specific gain‐ and loss‐of‐function strategies, we revealed a role for liver GADD45β in the coordination of liver fatty acid uptake, through cytoplasmic retention of FABP1, ultimately impacting obesity‐driven hyperglycaemia. In summary, fasting stress‐induced GADD45β represents a liver‐specific molecular event promoting adaptive metabolic function. Synopsis: Fasting is shown to induce liver GADD45β, which functions as an adapter protein to retain FABP1 in the cytoplasm and restrain fatty acid uptake. The blunting of GADD45β induction occurring in obesity/aging may explain the altered lipid metabolism. An altered lipid metabolism signature is especially apparent in the fasted state of obese and aged mice.Fasting induction of GADD45β is blunted in the liver of obese/aged mice and T2D humans.During fasting, liver GADD45β controls systemic and hepatic lipid handling via cytoplasmic FABP1 retention.Liver GADD45β expression improves glucose homoeostasis in obesity. | ||
| 650 | 4 | |a FABP1 | |
| 650 | 4 | |a hormesis | |
| 650 | 4 | |a lipid | |
| 650 | 4 | |a metabolism | |
| 650 | 4 | |a stress | |
| 700 | 1 | |a Zota, Annika |e VerfasserIn |0 (DE-588)112410268X |0 (DE-627)877824991 |0 (DE-576)482302194 |4 aut | |
| 700 | 1 | |a Sijmonsma, Tjeerd P. |e VerfasserIn |0 (DE-588)1147590567 |0 (DE-627)1006339280 |0 (DE-576)495880736 |4 aut | |
| 700 | 1 | |a Seibert, Oksana |e VerfasserIn |0 (DE-588)1033885320 |0 (DE-627)742732444 |0 (DE-576)381557197 |4 aut | |
| 700 | 1 | |a Guia, Roldan M. de |e VerfasserIn |0 (DE-588)1076134181 |0 (DE-627)834457059 |0 (DE-576)444977031 |4 aut | |
| 700 | 1 | |a Niopek, Katharina |e VerfasserIn |0 (DE-588)1147589313 |0 (DE-627)100633808X |0 (DE-576)495879312 |4 aut | |
| 700 | 1 | |a Berriel Diaz, Mauricio |d 1971- |e VerfasserIn |0 (DE-588)1124103996 |0 (DE-627)877827648 |0 (DE-576)482304693 |4 aut | |
| 700 | 1 | |a Okun, Jürgen G. |d 1968- |e VerfasserIn |0 (DE-588)121578232 |0 (DE-627)705551415 |0 (DE-576)292781296 |4 aut | |
| 700 | 1 | |a Herzig, Stephan |d 1969- |e VerfasserIn |0 (DE-588)12146623X |0 (DE-627)705470857 |0 (DE-576)292725949 |4 aut | |
| 700 | 1 | |a Rose, Adam J. |e VerfasserIn |0 (DE-588)1124103651 |0 (DE-627)877826994 |0 (DE-576)482304014 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |a European Molecular Biology Organization |t EMBO molecular medicine |d [London] : Nature Publishing Group UK, 2009 |g 8(2016), 6, Seite 654-669 |h Online-Ressource |w (DE-627)594772761 |w (DE-600)2485479-7 |w (DE-576)305355961 |x 1757-4684 |7 nnas |
| 773 | 1 | 8 | |g volume:8 |g year:2016 |g number:6 |g pages:654-669 |g extent:16 |a Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health |
| 856 | 4 | 0 | |u http://dx.doi.org/10.15252/emmm.201505801 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://embomolmed.embopress.org/content/8/6/654 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190301 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1124103651 |a Rose, Adam J. |m 1124103651:Rose, Adam J. |d 140000 |e 140000PR1124103651 |k 0/140000/ |p 15 |y j | ||
| 998 | |g 12146623X |a Herzig, Stephan |m 12146623X:Herzig, Stephan |d 700000 |d 706000 |d 50000 |e 700000PH12146623X |e 706000PH12146623X |e 50000PH12146623X |k 0/700000/ |k 1/700000/706000/ |k 0/50000/ |p 14 | ||
| 998 | |g 121578232 |a Okun, Jürgen G. |m 121578232:Okun, Jürgen G. |d 910000 |d 910500 |e 910000PO121578232 |e 910500PO121578232 |k 0/910000/ |k 1/910000/910500/ |p 13 | ||
| 998 | |g 1124103996 |a Berriel Diaz, Mauricio |m 1124103996:Berriel Diaz, Mauricio |d 140000 |e 140000PB1124103996 |k 0/140000/ |p 10 | ||
| 998 | |g 1147589313 |a Niopek, Katharina |m 1147589313:Niopek, Katharina |d 50000 |e 50000PN1147589313 |k 0/50000/ |p 9 | ||
| 998 | |g 1076134181 |a Guia, Roldan M. de |m 1076134181:Guia, Roldan M. de |d 910000 |d 950000 |d 950950 |e 910000PG1076134181 |e 950000PG1076134181 |e 950950PG1076134181 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 8 | ||
| 998 | |g 1033885320 |a Seibert, Oksana |m 1033885320:Seibert, Oksana |d 910000 |d 950000 |d 950950 |e 910000PS1033885320 |e 950000PS1033885320 |e 950950PS1033885320 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 4 | ||
| 998 | |g 1147590567 |a Sijmonsma, Tjeerd P. |m 1147590567:Sijmonsma, Tjeerd P. |d 910000 |d 950000 |d 950950 |e 910000PS1147590567 |e 950000PS1147590567 |e 950950PS1147590567 |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 3 | ||
| 998 | |g 112410268X |a Zota, Annika |m 112410268X:Zota, Annika |d 910000 |d 950000 |d 950950 |e 910000PZ112410268X |e 950000PZ112410268X |e 950950PZ112410268X |k 0/910000/ |k 1/910000/950000/ |k 2/910000/950000/950950/ |p 2 | ||
| 998 | |g 1071497456 |a Fuhrmeister, Jessica |m 1071497456:Fuhrmeister, Jessica |d 910000 |d 910100 |e 910000PF1071497456 |e 910100PF1071497456 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1588269493 |e 3057101402 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1588269493","physDesc":[{"extent":"16 S."}],"origin":[{"dateIssuedKey":"2016","dateIssuedDisp":"3 May 2016"}],"titleAlt":[{"title":"Fasting‐induced liver GADD45 beta restrains hepatic fatty acid uptake and improves metabolic health"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Jessica Fuhrmeister, Annika Zota, Tjeerd P. Sijmonsma, Oksana Seibert, Şahika Cıngır, Kathrin Schmidt, Nicola Vallon, Roldan M. de Guia, Katharina Niopek, Mauricio Berriel Diaz, Adriano Maida, Matthias Blüher, Jürgen G. Okun, Stephan Herzig and Adam J. Rose"]},"person":[{"family":"Fuhrmeister","display":"Fuhrmeister, Jessica","role":"aut","given":"Jessica"},{"family":"Zota","display":"Zota, Annika","given":"Annika","role":"aut"},{"given":"Tjeerd P.","role":"aut","family":"Sijmonsma","display":"Sijmonsma, Tjeerd P."},{"role":"aut","given":"Oksana","display":"Seibert, Oksana","family":"Seibert"},{"role":"aut","given":"Roldan M. de","display":"Guia, Roldan M. de","family":"Guia"},{"given":"Katharina","role":"aut","display":"Niopek, Katharina","family":"Niopek"},{"display":"Berriel Diaz, Mauricio","family":"Berriel Diaz","given":"Mauricio","role":"aut"},{"role":"aut","given":"Jürgen G.","family":"Okun","display":"Okun, Jürgen G."},{"family":"Herzig","display":"Herzig, Stephan","role":"aut","given":"Stephan"},{"role":"aut","given":"Adam J.","display":"Rose, Adam J.","family":"Rose"}],"id":{"doi":["10.15252/emmm.201505801"],"eki":["1588269493"]},"title":[{"title_sort":"Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health","title":"Fasting‐induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health"}],"language":["eng"],"relHost":[{"part":{"extent":"16","text":"8(2016), 6, Seite 654-669","pages":"654-669","year":"2016","volume":"8","issue":"6"},"disp":"European Molecular Biology OrganizationEMBO molecular medicine","language":["eng"],"title":[{"title_sort":"EMBO molecular medicine","title":"EMBO molecular medicine"}],"note":["Gesehen am 5. November 2022","Fortsetzung der Druck-Ausgabe"],"corporate":[{"role":"aut","display":"European Molecular Biology Organization"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisher":"Nature Publishing Group UK ; EMBO Press ; Wiley-VCH","dateIssuedDisp":"[2009]-","publisherPlace":"[London] ; Heidelberg ; Weinheim"}],"recId":"594772761","pubHistory":["Vol. 1, No. 1 (Apr 1, 2009)-"],"id":{"issn":["1757-4684"],"zdb":["2485479-7"],"doi":["10.1002/(ISSN)1757-4684"],"eki":["594772761"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"name":{"displayForm":["European Molecular Biology Organization (EMBO)"]}}],"note":["Gesehen am 01.03.2019"]} | ||
| SRT | |a FUHRMEISTEFASTINGIND3201 | ||