68Ga-PSMA-11 PET/CT in primary and recurrent prostate carcinoma: implications for radiotherapeutic management in 121 patients
The present study analyzed the impact of Gallium-68 (68Ga)-labeled prostate-specific membrane antigen-HBED-CC (68Ga-PSMA-11) positron-emission tomography (PET)/computed tomography (CT) on radiotherapeutic management in a large cohort of men with primary or recurrent disease. Methods: This study inve...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Journal of nuclear medicine
Year: 2018, Jahrgang: 60, Heft: 2, Pages: 234-240 |
| ISSN: | 2159-662X |
| DOI: | 10.2967/jnumed.118.211086 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.2967/jnumed.118.211086 Verlag, Volltext: http://jnm.snmjournals.org/content/early/2018/07/05/jnumed.118.211086 
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| Verfasserangaben: | Stefan A. Koerber, Leon Will, Clemens Kratochwil, Matthias F. Haefner, Henrik Rathke, Christophe Kremer, Jonas Merkle, Klaus Herfarth, Klaus Kopka, Peter L. Choyke, Tim Holland-Letz, Uwe Haberkorn, Juergen Debus, Frederik L. Giesel |
MARC
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| 245 | 1 | 0 | |a 68Ga-PSMA-11 PET/CT in primary and recurrent prostate carcinoma |b implications for radiotherapeutic management in 121 patients |c Stefan A. Koerber, Leon Will, Clemens Kratochwil, Matthias F. Haefner, Henrik Rathke, Christophe Kremer, Jonas Merkle, Klaus Herfarth, Klaus Kopka, Peter L. Choyke, Tim Holland-Letz, Uwe Haberkorn, Juergen Debus, Frederik L. Giesel |
| 246 | 3 | 3 | |a 68 Ga-PSMA-11 PET/CT in primary and recurrent prostate carcinoma |
| 264 | 1 | |c 2019 | |
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| 500 | |a Im Titel ist "68" in 68Ga-PSMA-11 PET/CT hochgestellt | ||
| 500 | |a Gesehen am 12.03.2019 | ||
| 520 | |a The present study analyzed the impact of Gallium-68 (68Ga)-labeled prostate-specific membrane antigen-HBED-CC (68Ga-PSMA-11) positron-emission tomography (PET)/computed tomography (CT) on radiotherapeutic management in a large cohort of men with primary or recurrent disease. Methods: This study investigated 121 men with carcinoma of the prostate who underwent 68Ga-PSMA-11 PET/CT as well as conventional imaging. 50 patients were treatment naive, 11 had persistent prostate-specific antigen (PSA) soon after surgery and 60 presented with recurrent PSA following definitive therapy. Changes in TNM classification of malignant tumors (TNM) stage and radiotherapeutic management after 68Ga-PSMA-11 imaging were compared to results achieved with conventional imaging. Results: In total, a change in TNM stage and radiotherapeutic management was observed for 49 patients (40.5%) and 62 patients (51.2%), respectively. In treatment naïve patients, a change in TNM stage and radiotheraeutic plan occurred in 26.0% and 44.0% of the cohort respectively. For patients with PSA persistence or recurrence, TNM and radiotherapeutic management changed in 50.7% and 56.3% respectively. Conclusion: 68Ga-PSMA-11 PET/CT may shortly become an indispensable tool for detecting prostate cancer lesions in treatment-naïve patients as well as in men with recurrent disease or persistent PSA and seems to be very helpful in personalizing radiotherapeutic management to the individual patients’ distribution of disease. | ||
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| 650 | 4 | |a PSMA | |
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| 650 | 4 | |a radiotherapy | |
| 650 | 4 | |a staging | |
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