MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP
The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 February 2019
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| In: |
Nature Communications
Year: 2019, Jahrgang: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-08450-4 |
| Online-Zugang: | Verlag, Volltext: http://dx.doi.org/10.1038/s41467-019-08450-4 Verlag, Volltext: https://www.nature.com/articles/s41467-019-08450-4 
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| Verfasserangaben: | Yahui Yan, Claudia Rato, Lukas Rohland, Steffen Preissler & David Ron |
| Zusammenfassung: | The role of mesencephalic astrocyte-derived neurotrophic factor (MANF) in maintenance of protein folding homeostasis inside the ER has remained unclear. Here the authors determine the structure of the complex between MANF and the ER-localized chaperone BiP and provide evidence that MANF serves as an anti-nucleotide exchange factor for BiP. |
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| Beschreibung: | Gesehen am 15.03.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-08450-4 |