Buchumschlag

Respiratory Regulation - The Molecular Approach

This book, an international collaborative effort in the area of molecular respiratory research, showcases a broad range of multidisciplinary approaches to unravel and analyze the underlying mechanisms of a spectrum of respiratory ailments. It discusses immunological and genetic respiratory disorders...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
1. Verfasser: Pokorski, Mieczysław (VerfasserIn)
Dokumenttyp: Book/Monograph
Sprache:Englisch
Veröffentlicht: Dordrecht Springer 2013
Schriftenreihe:Advances in experimental medicine and biology 756
In: Advances in experimental medicine and biology (756)

Volumes / Articles: Show Volumes / Articles.
DOI:10.1007/978-94-007-4549-0
Online-Zugang:Verlag, Volltext: https://doi.org/10.1007/978-94-007-4549-0
Resolving-System, lizenzpflichtig, Volltext: http://dx.doi.org/10.1007/978-94-007-4549-0
Cover: https://swbplus.bsz-bw.de/bsz373364709cov.jpg
Volltext
Verfasserangaben:edited by Mieczyslaw Pokorski
Inhaltsangabe:
  • Respiratory Regulation -The Molecular Approach; Preface; Contents; Chapter 1: Neutrophil Extracellular Trap in Human Diseases; 1.1 Introduction; 1.2 Characterization of Neutrophil Extracellular Traps; 1.3 NETs in Neoplasm of Developmental Age; 1.4 NETs in Autoimmunity; References; Chapter 2: Tiotropium Increases PPARγ and Decreases CREB in Cells Isolated from Induced Sputum of COPD Patients; 2.1 Introduction; 2.2 Methods; 2.2.1 Subjects and Treatment; 2.2.2 Sputum Induction and Processing; 2.3 Results; 2.4 Discussion; References
  • Chapter 3: Expression of Ki-67, Bcl-2, Survivin and p53 Proteins in Patients with Pulmonary Carcinoma3.1 Introduction; 3.2 Methods; 3.2.1 Evaluation of Immunochemical Staining; 3.2.2 Statistical Analysis; 3.3 Results; 3.4 Discussion; References; Chapter 4: Indacaterol Add-On Therapy Improves Lung Function, Exercise Capacity and Life Quality of COPD Patients; 4.1 Introduction; 4.2 Methods; 4.3 Results; 4.4 Discussion; References; Chapter 5: Rapid DNA Extraction Protocol for Detection of Alpha-1 Antitrypsin Deficiency from Dried Blood Spots by Real-Time PCR; 5.1 Introduction; 5.2 Methods
  • 5.2.1 Preparation of DBS Samples5.2.2 DNA Extraction from DBS; 5.2.3 Genotyping of PI*S and PI*Z AAT Alleles by Real-Time PCR; 5.2.4 AAT Sequence Analysis; 5.2.5 Quantitative Determination of Serum AAT Concentration by Immune Nephelometry; 5.2.6 Phenotyping of Serum AAT by Isoelectrofocusing (IEF); 5.3 Results; 5.4 Discussion; References; Chapter 6: CRAC Ion Channels and Airway Defense Reflexes in Experimental Allergic Inflammation; 6.1 Introduction; 6.2 Methods; 6.2.1 Animals; 6.2.2 Antigen-Induced Airway Hyperresponsiveness; 6.2.3 Chemicals
  • 6.2.4 Evaluation of Airway Smooth Muscle (ASM) Reactivity In Vivo6.2.5 Cough Reflex Assessment; 6.2.6 Evaluation of Airway Smooth Muscle (ASM) Reactivity In Vivo; 6.2.7 Measurement of Exhaled NO (E NO); 6.2.8 Histological Evaluation; 6.2.9 Statistical Analysis; 6.3 Results; 6.3.1 Airways Smooth Muscle Reactivity In Vivo; 6.3.2 Airway Smooth Muscle Reactivity In Vitro; 6.3.3 Exhaled NO Changes; 6.3.4 Citric Acid-Induced Cough Reflex; 6.3.5 Histological Results; 6.4 Discussion; References; Chapter 7: Experimental Model of Allergic Asthma; 7.1 Introduction; 7.2 Methods
  • 7.2.1 Sensitization of Guinea Pigs7.2.2 Tracheal Smooth Muscle Contraction in vitro; 7.2.3 Evaluation of Airway Reactivity in vivo; 7.2.4 Chemically Induced Cough; 7.2.5 Measurement of In fl ammatory Cytokines; 7.2.6 Histological Examination; 7.2.7 Data Analysis; 7.3 Results; 7.4 Discussion; References; Chapter 8: Effects of Selective Inhibition of PDE4 and PDE7 on Airway Reactivity and Cough in Healthy and Ovalbumin-Sensitized Guinea Pigs; 8.1 Introduction; 8.2 Methods; 8.2.1 Antigen-Induced Airway Hyperresponsiveness; 8.2.2 Cough Reflex Assessment
  • 8.2.3 Evaluation of Airway Reactivity In Vivo

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