Buchumschlag

Ten years of progress in GW/P body research

GW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chan’s group in 2002. These bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation. The detailed biolo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Weitere Verfasser: Chan, Edward K. L. (HerausgeberIn) , Fritzler, Marvin J. (HerausgeberIn)
Dokumenttyp: Book/Monograph
Sprache:Englisch
Veröffentlicht: New York, NY Springer 2013
Schriftenreihe:Advances in experimental medicine and biology 768
In: Advances in experimental medicine and biology (768)

Volumes / Articles: Show Volumes / Articles.
DOI:10.1007/978-1-4614-5107-5
Schlagworte:
Proteine
Biologischer Abbau
Messenger-RNS
Online-Zugang:Verlag, Volltext: https://doi.org/10.1007/978-1-4614-5107-5
Resolving-System, lizenzpflichtig, Volltext: http://dx.doi.org/10.1007/978-1-4614-5107-5
Cover: https://swbplus.bsz-bw.de/bsz37759282xcov.jpg
Volltext
Verfasserangaben:edited by Edward K. L. Chan, Marvin J. Fritzler
Inhaltsangabe:
  • Ten Years of Progress in GW/P Body Research; Preface; Contents; Contributors; Chapter 1: Introduction: The GW Body Story as an Example of Autoantibodies with Signi fi cant Impacts to Molecular Cell Biology; References; Chapter 2: The Discovery of GW Bodies; 2.1 Introduction; 2.2 A Short History of the Discovery of GWB; 2.3 Summary and Conclusions; References; Chapter 3: The Discovery and Analysis of P Bodies; 3.1 Introduction; 3.2 The Mechanisms of mRNA Decay; 3.3 The Discovery of P Bodies; 3.4 Composition of P Bodies; 3.5 Assembly of P Bodies in Yeast
  • 3.6 P Bodies, Stress Granules, and the mRNA Cycle3.7 P Bodies and mRNA Decay; 3.8 P Bodies and NMD; 3.9 P Body and miRNA; 3.10 P Bodies Associate with Cellular Organelles; 3.11 P Body Dynamics and Cellular Processes; 3.12 P Bodies Affect Viral Life Cycles; 3.13 Future Directions; References; Chapter 4: Autoantibodies to Argonaute 2 (Su Antigen); 4.1 Introduction; 4.2 History of Anti-Su Antibodies; 4.3 Su Antigens; 4.4 Detection of Anti-Su Antibodies; 4.5 Prevalence and Clinical Signi fi cance of Anti-Su/Ago2 Antibodies; 4.6 Production of Anti-Su/Ago2 in Animal Models
  • 4.7 Mechanism of Production4.8 Conclusions; References; Chapter 5: GW/P-Bodies and Autoimmune Disease; 5.1 Introduction; 5.2 Identi fi cation of Ge-1; 5.3 Identi fi cation of Additional Serum Samples Containing Anti-GW/P-Body Autoantibodies and Use of These Sera to Further De fi ne the Composition of GW/P-Bodies; 5.4 The Use of Human Sera and Protein Arrays to Identify GW/P-Body Components; 5.5 Reference Sera Contain Antibodies Directed Against Both Ge-1 and GW182; 5.6 The Clinical Signi fi cance of Anti-P-Body Autoantibodies
  • 5.7 Other Autoantigens Identi fi ed Using Ge Serum: An Unexpected Link Between GW/P Bodies and PML-Sp100 Nuclear Bodies5.8 Summary; References; Chapter 6: Function of GW182 and GW Bodies in siRNA and miRNA Pathways; 6.1 Introduction; 6.2 Role of GW182 and GWBs in siRNA Silencing Pathway; 6.3 Disruption of GW Bodies Impaired Mammalian RNA Interference; 6.4 Small Interfering RNA-Mediated Silencing Induces Target-Dependent Assembly of GW/P-Bodies; 6.5 Role of GW182 and GWBs in miRNA Silencing Pathway
  • 6.6 GW182 Has a Longer Isoform TNGW1 That Both Served as Translational Repressors in Ago2-Mediated Silencing6.7 The C-Terminal Half of Human Ago2 Bound to Multiple GW-Rich Regions of GW182 and Required GW182 to Mediate Silencing; 6.8 Divergent GW182 Functional Domains in the Regulation of Translational Silencing; 6.9 Crosstalk Between miRNA and siRNA: Common Roles of GWBs; 6.10 Formation of GW Bodies is the Consequence of microRNA Genesis; 6.11 Conclusions and Working Model; References; Chapter 7: Post-transcriptional Stimulation of Gene Expression by MicroRNAs; 7.1 MicroRNAs
  • 7.2 Translation Regulation

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