Hemodialysis vascular access and subsequent transplantation: a report from the ESPN/ERA-EDTA Registry

BackgroundCurrent guidelines advocate use of arteriovenous fistula (AVF) over central venous catheter (CVC) for children starting hemodialysis (HD). European data on current practice, determinants of access choice and switches, patient survival, and access to transplantation are limited.MethodsWe in...

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Main Authors: Böhm, Michael (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: 2019
In: Pediatric nephrology
Year: 2019, Volume: 34, Issue: 4, Pages: 713-721
ISSN:1432-198X
DOI:10.1007/s00467-018-4129-6
Online Access:Verlag, Volltext: https://doi.org/10.1007/s00467-018-4129-6
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Author Notes:Michael Boehm, Marjolein Bonthuis, Marlies Noordzij, Jérôme Harambat, Jaap W. Groothoff, Ángel Alonso Melgar, Jadranka Buturovic, Ruhan Dusunsel, Marc Fila, Anna Jander, Linda Koster-Kamphuis, Gregor Novljan, Pedro J. Ortega, Fabio Paglialonga, Maria T. Saravo, Constantinos J. Stefanidis, Christoph Aufricht, Kitty J. Jager, Franz Schaefer

MARC

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520 |a BackgroundCurrent guidelines advocate use of arteriovenous fistula (AVF) over central venous catheter (CVC) for children starting hemodialysis (HD). European data on current practice, determinants of access choice and switches, patient survival, and access to transplantation are limited.MethodsWe included incident patients from 18 European countries who started HD from 2000 to 2013 for whom vascular access type was reported to the ESPN/ERA-EDTA Registry. Data were evaluated using descriptive statistics, logistic and Cox regression models, and cumulative incidence competing risk analysis.ResultsThree hundred ninety-three (55.1%) of 713 children started HD with a CVC and were more often females, younger, had more often an unknown diagnosis, glomerulonephritis, or vasculitis, and lower hemoglobin and height-SDS at HD initiation. AVF patients were 91% less likely to switch to a second access, and two-year patient survival was 99.6% (CVC, 97.2%). Children who started with an AVF were less likely to receive a living donor transplant (adjusted HR, 0.30; 95% CI, 0.16-0.54) and more likely to receive a deceased donor transplant (adjusted HR, 1.50; 95% CI, 1.17-1.93), even after excluding patients who died or were transplanted in the first 6 months.ConclusionsCVC remains the most frequent type of vascular access in European children commencing HD. Our results suggest that the choice for CVC is influenced by the time of referral, rapid onset of end-stage renal disease, young age, and an expected short time to transplantation. The role of vascular access type on the pattern between living and deceased donation in subsequent transplantation requires further study. 
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650 4 |a Access to transplantation 
650 4 |a Arteriovenous fistula 
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650 4 |a End-stage renal disease in children 
650 4 |a Renal replacement therapy 
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