Buchumschlag

Titin antibodies in “seronegative” myasthenia gravis: a new role for an old antigen

Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction of skeletal muscles. Triple-seronegative MG (tSN-MG, without detectable AChR, MuSK and LRP4 antibodies), which accounts for ~10% of MG patients, presents a serious gap in MG diagnosis and compli...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Stergiou, Christos (VerfasserIn) , Labeit, Dittmar (VerfasserIn) , Labeit, Siegfried (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 15 March 2016
In: Journal of neuroimmunology
Year: 2016, Jahrgang: 292, Pages: 108-115
ISSN:1872-8421
DOI:10.1016/j.jneuroim.2016.01.018
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.jneuroim.2016.01.018
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165572816300182
Volltext
Verfasserangaben:C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, N.E. Gilhus, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, J. Bogomolovas, D. Labeit, S. Labeit, S.J. Tzartos

MARC

LEADER 00000caa a2200000 c 4500
001 166245211X
003 DE-627
005 20230426172411.0
007 cr uuu---uuuuu
008 190327s2016 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.jneuroim.2016.01.018  |2 doi 
035 |a (DE-627)166245211X 
035 |a (DE-599)KXP166245211X 
035 |a (OCoLC)1341205658 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Stergiou, Christos  |e VerfasserIn  |0 (DE-588)1181902614  |0 (DE-627)1662450567  |4 aut 
245 1 0 |a Titin antibodies in “seronegative” myasthenia gravis  |b a new role for an old antigen  |c C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, N.E. Gilhus, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, J. Bogomolovas, D. Labeit, S. Labeit, S.J. Tzartos 
264 1 |c 15 March 2016 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 27.03.2019 
520 |a Myasthenia gravis (MG) is an autoimmune disease caused by antibodies targeting the neuromuscular junction of skeletal muscles. Triple-seronegative MG (tSN-MG, without detectable AChR, MuSK and LRP4 antibodies), which accounts for ~10% of MG patients, presents a serious gap in MG diagnosis and complicates differential diagnosis of similar disorders. Several AChR antibody positive patients (AChR-MG) also have antibodies against titin, usually detected by ELISA. We have developed a very sensitive radioimmunoprecipitation assay (RIPA) for titin antibodies, by which many previously negative samples were found positive, including several from tSN-MG patients. The validity of the RIPA results was confirmed by western blots. Using this RIPA we screened 667 MG sera from 13 countries; as expected, AChR-MG patients had the highest frequency of titin antibodies (40.9%), while MuSK-MG and LRP4-MG patients were positive in 14.6% and 16.4% respectively. Most importantly, 13.4% (50/372) of the tSN-MG patients were also titin antibody positive. None of the 121 healthy controls or the 90 myopathy patients, and only 3.6% (7/193) of other neurological disease patients were positive. We thus propose that the present titin antibody RIPA is a useful tool for serological MG diagnosis of tSN patients. 
650 4 |a Myasthenia gravis 
650 4 |a Autoantibodies 
650 4 |a Diagnosis 
650 4 |a Radioimmunoprecipitation assay 
650 4 |a Seronegative 
650 4 |a Titin 
700 1 |a Labeit, Dittmar  |d 1953-2018  |e VerfasserIn  |0 (DE-588)1056068450  |0 (DE-627)793905982  |0 (DE-576)41207639X  |4 aut 
700 1 |a Labeit, Siegfried  |d 1960-  |e VerfasserIn  |0 (DE-588)1033566837  |0 (DE-627)741562375  |0 (DE-576)381187314  |4 aut 
773 0 8 |i Enthalten in  |t Journal of neuroimmunology  |d Amsterdam [u.a.] : Elsevier Science, 1981  |g 292(2016), Seite 108-115  |h Online-Ressource  |w (DE-627)306659778  |w (DE-600)1500497-1  |w (DE-576)081986408  |x 1872-8421  |7 nnas  |a Titin antibodies in “seronegative” myasthenia gravis a new role for an old antigen 
773 1 8 |g volume:292  |g year:2016  |g pages:108-115  |g extent:8  |a Titin antibodies in “seronegative” myasthenia gravis a new role for an old antigen 
856 4 0 |u https://doi.org/10.1016/j.jneuroim.2016.01.018  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u http://www.sciencedirect.com/science/article/pii/S0165572816300182  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190327 
993 |a Article 
994 |a 2016 
998 |g 1033566837  |a Labeit, Siegfried  |m 1033566837:Labeit, Siegfried  |d 60000  |d 61600  |e 60000PL1033566837  |e 61600PL1033566837  |k 0/60000/  |k 1/60000/61600/  |p 38 
998 |g 1056068450  |a Labeit, Dittmar  |m 1056068450:Labeit, Dittmar  |d 60000  |e 60000PL1056068450  |k 0/60000/  |p 37 
999 |a KXP-PPN166245211X  |e 341715880X 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"title":[{"title_sort":"Titin antibodies in “seronegative” myasthenia gravis","title":"Titin antibodies in “seronegative” myasthenia gravis","subtitle":"a new role for an old antigen"}],"relHost":[{"pubHistory":["1.1981 -"],"title":[{"title_sort":"Journal of neuroimmunology","subtitle":"official journal of the International Society for Neuroimmunology","title":"Journal of neuroimmunology"}],"language":["eng"],"part":{"extent":"8","pages":"108-115","volume":"292","text":"292(2016), Seite 108-115","year":"2016"},"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1981","dateIssuedDisp":"1981-","publisher":"Elsevier Science"}],"recId":"306659778","type":{"media":"Online-Ressource","bibl":"periodical"},"physDesc":[{"extent":"Online-Ressource"}],"id":{"zdb":["1500497-1"],"issn":["1872-8421"],"eki":["306659778"]},"disp":"Titin antibodies in “seronegative” myasthenia gravis a new role for an old antigenJournal of neuroimmunology","note":["Gesehen am 19.02.20","Ungezählte Beil.: Supplement"]}],"note":["Gesehen am 27.03.2019"],"physDesc":[{"extent":"8 S."}],"id":{"eki":["166245211X"],"doi":["10.1016/j.jneuroim.2016.01.018"]},"recId":"166245211X","origin":[{"dateIssuedDisp":"15 March 2016","dateIssuedKey":"2016"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"family":"Stergiou","role":"aut","given":"Christos","display":"Stergiou, Christos"},{"display":"Labeit, Dittmar","role":"aut","given":"Dittmar","family":"Labeit"},{"family":"Labeit","display":"Labeit, Siegfried","given":"Siegfried","role":"aut"}],"name":{"displayForm":["C. Stergiou, K. Lazaridis, V. Zouvelou, J. Tzartos, R. Mantegazza, C. Antozzi, F. Andreetta, A. Evoli, F. Deymeer, G. Saruhan-Direskeneli, H. Durmus, T. Brenner, A. Vaknin, S. Berrih-Aknin, A. Behin, T. Sharshar, M. De Baets, M. Losen, P. Martinez-Martinez, K.A. Kleopa, E. Zamba-Papanicolaou, T. Kyriakides, A. Kostera-Pruszczyk, P. Szczudlik, B. Szyluk, D. Lavrnic, I. Basta, S. Peric, C. Tallaksen, A. Maniaol, N.E. Gilhus, C. Casasnovas Pons, J. Pitha, M. Jakubíkova, F. Hanisch, J. Bogomolovas, D. Labeit, S. Labeit, S.J. Tzartos"]}} 
SRT |a STERGIOUCHTITINANTIB1520 

Ähnliche Einträge