VALFORTA: a randomised trial to validate the FORTA (Fit fOR The Aged) classification
Trial design: to further validate the FORTA (Fit fOR The Aged) concept, a bicentric randomised, controlled trial was run in two geriatric clinics. Methods: patients (≥65 years, ≥3 drugs or ≥60 years, ≥6 drugs) with three relevant diseases and hospitalisation for ≥5 days were randomised. In the inter...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
18 January 2016
|
| In: |
Age & ageing
Year: 2016, Jahrgang: 45, Heft: 2, Pages: 262-267 |
| ISSN: | 1468-2834 |
| DOI: | 10.1093/ageing/afv200 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1093/ageing/afv200 Verlag, Volltext: https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/ageing/article/45/2/262/2195343 
|
| Verfasserangaben: | Martin Wehling, Heinrich Burkhardt, Alexandra Kuhn-Thiel, Farhad Pazan, Christina Throm, Christel Weiss, Helmut Frohnhofen |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 166248285X | ||
| 003 | DE-627 | ||
| 005 | 20230426172414.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190328s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/ageing/afv200 |2 doi | |
| 035 | |a (DE-627)166248285X | ||
| 035 | |a (DE-599)KXP166248285X | ||
| 035 | |a (OCoLC)1341205306 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wehling, Martin |d 1957- |e VerfasserIn |0 (DE-588)129939331 |0 (DE-627)484463152 |0 (DE-576)297912577 |4 aut | |
| 245 | 1 | 0 | |a VALFORTA |b a randomised trial to validate the FORTA (Fit fOR The Aged) classification |c Martin Wehling, Heinrich Burkhardt, Alexandra Kuhn-Thiel, Farhad Pazan, Christina Throm, Christel Weiss, Helmut Frohnhofen |
| 264 | 1 | |c 18 January 2016 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 28.03.2019 | ||
| 520 | |a Trial design: to further validate the FORTA (Fit fOR The Aged) concept, a bicentric randomised, controlled trial was run in two geriatric clinics. Methods: patients (≥65 years, ≥3 drugs or ≥60 years, ≥6 drugs) with three relevant diseases and hospitalisation for ≥5 days were randomised. In the intervention, but not the control group, a FORTA team instructed ward physicians on FORTA. FORTA is the first positive/negative listing approach labelling medications used to treat chronic illnesses in older patients from A (indispensable), B (beneficial), C (questionable) to D (avoid). The primary end point was the FORTA score: sum of medication errors classified as over-, under- and mistreatment. Consecutive patients were randomised to the intervention and control ward; outcome assessment was blinded. Results: four hundred and nine patients (age 81.5 years, 64% female, hospitalisation 17.4 days) were included. The primary end point was significantly (P < 0.0001) more reduced in the intervention versus control groups (2.7 ± 2.25 versus 1 ± 1.8, mean ± SD, intergroup comparison of admission/discharge differences). Over- and under-treatment scores and use of A (increase) and D (decrease) drugs were significantly improved (P < 0.01). The total number of adverse drug reactions (ADRs) was significantly reduced by FORTA (P < 0.05, number needed to treat is 5). Activities of daily living and renal failure improved significantly (P < 0.05). Blood pressure remained constant in the intervention, but decreased significantly in the control group. Conclusion: applying FORTA to hospitalised geriatric patients leads to improvement of medication quality and may improve secondary clinical end points (e.g. ADRs). The concept is amenable to successful communication and implementation. | ||
| 700 | 1 | |a Burkhardt, Heinrich |d 1962- |e VerfasserIn |0 (DE-588)141180188 |0 (DE-627)625414624 |0 (DE-576)322588332 |4 aut | |
| 700 | 1 | |a Pazan, Farhad |d 1980- |e VerfasserIn |0 (DE-588)116216302X |0 (DE-627)102561416X |0 (DE-576)507240219 |4 aut | |
| 700 | 1 | |a Throm, Christina |d 1989- |e VerfasserIn |0 (DE-588)1171761260 |0 (DE-627)1040702619 |0 (DE-576)51384631X |4 aut | |
| 700 | 1 | |a Weiß, Christel |d 1958- |e VerfasserIn |0 (DE-588)123287707 |0 (DE-627)082463417 |0 (DE-576)168356104 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Age & ageing |d Oxford : Oxford Univ. Press, 1972 |g 45(2016), 2, Seite 262-267 |h Online-Ressource |w (DE-627)340873442 |w (DE-600)2065766-3 |w (DE-576)105797057 |x 1468-2834 |7 nnas |a VALFORTA a randomised trial to validate the FORTA (Fit fOR The Aged) classification |
| 773 | 1 | 8 | |g volume:45 |g year:2016 |g number:2 |g pages:262-267 |g extent:6 |a VALFORTA a randomised trial to validate the FORTA (Fit fOR The Aged) classification |
| 856 | 4 | 0 | |u https://doi.org/10.1093/ageing/afv200 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://academic-oup-com.ezproxy.medma.uni-heidelberg.de/ageing/article/45/2/262/2195343 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190328 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 123287707 |a Weiß, Christel |m 123287707:Weiß, Christel |d 60000 |d 60200 |d 60250 |e 60000PW123287707 |e 60200PW123287707 |e 60250PW123287707 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60250/ |p 6 | ||
| 998 | |g 1171761260 |a Throm, Christina |m 1171761260:Throm, Christina |d 60000 |d 65400 |e 60000PT1171761260 |e 65400PT1171761260 |k 0/60000/ |k 1/60000/65400/ |p 5 | ||
| 998 | |g 116216302X |a Pazan, Farhad |m 116216302X:Pazan, Farhad |d 60000 |d 65400 |e 60000PP116216302X |e 65400PP116216302X |k 0/60000/ |k 1/60000/65400/ |p 4 | ||
| 998 | |g 141180188 |a Burkhardt, Heinrich |m 141180188:Burkhardt, Heinrich |d 60000 |d 61300 |e 60000PB141180188 |e 61300PB141180188 |k 0/60000/ |k 1/60000/61300/ |p 2 | ||
| 998 | |g 129939331 |a Wehling, Martin |m 129939331:Wehling, Martin |d 60000 |d 65400 |e 60000PW129939331 |e 65400PW129939331 |k 0/60000/ |k 1/60000/65400/ |p 1 |x j | ||
| 999 | |a KXP-PPN166248285X |e 3417222249 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1093/ageing/afv200"],"eki":["166248285X"]},"name":{"displayForm":["Martin Wehling, Heinrich Burkhardt, Alexandra Kuhn-Thiel, Farhad Pazan, Christina Throm, Christel Weiss, Helmut Frohnhofen"]},"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"166248285X","person":[{"family":"Wehling","given":"Martin","role":"aut","display":"Wehling, Martin"},{"family":"Burkhardt","given":"Heinrich","role":"aut","display":"Burkhardt, Heinrich"},{"role":"aut","display":"Pazan, Farhad","family":"Pazan","given":"Farhad"},{"family":"Throm","given":"Christina","display":"Throm, Christina","role":"aut"},{"display":"Weiß, Christel","role":"aut","given":"Christel","family":"Weiß"}],"title":[{"title_sort":"VALFORTA","title":"VALFORTA","subtitle":"a randomised trial to validate the FORTA (Fit fOR The Aged) classification"}],"relHost":[{"recId":"340873442","id":{"eki":["340873442"],"issn":["1468-2834"],"zdb":["2065766-3"]},"pubHistory":["1.1972 -"],"note":["Gesehen am 10.02.23","Fortsetzung der Druck-Ausgabe"],"origin":[{"dateIssuedDisp":"1972-","publisher":"Oxford Univ. Press","dateIssuedKey":"1972","publisherPlace":"Oxford"}],"physDesc":[{"extent":"Online-Ressource"}],"disp":"VALFORTA a randomised trial to validate the FORTA (Fit fOR The Aged) classificationAge & ageing","language":["eng"],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Age and ageing"}],"title":[{"title":"Age & ageing","title_sort":"Age & ageing","subtitle":"the journal of the British Geriatrics Society and the British Society for Research on Ageing"}],"corporate":[{"role":"isb","display":"British Geriatrics Society"}],"part":{"issue":"2","pages":"262-267","text":"45(2016), 2, Seite 262-267","extent":"6","volume":"45","year":"2016"}}],"physDesc":[{"extent":"6 S."}],"note":["Gesehen am 28.03.2019"],"origin":[{"dateIssuedDisp":"18 January 2016","dateIssuedKey":"2016"}]} | ||
| SRT | |a WEHLINGMARVALFORTA1820 | ||