Aberrant cortical neurodevelopment in major depressive disorder
Background - There is strong neuroimaging evidence that cortical alterations represent a core pathophysiological feature of major depressive disorder (MDD). Differential contributions of cortical features of neurodevelopmental origin, which may distinctly contribute to MDD vulnerability, disease-ons...
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| Hauptverfasser: | , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2019
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| In: |
Journal of affective disorders
Year: 2018, Jahrgang: 243, Pages: 340-347 |
| ISSN: | 1573-2517 |
| DOI: | 10.1016/j.jad.2018.09.021 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.jad.2018.09.021 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0165032718300466 
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| Verfasserangaben: | Mike M. Schmitgen, Malte S. Depping, Claudia Bach, Nadine D. Wolf, Katharina M. Kubera, Nenad Vasic, Dusan Hirjak, Fabio Sambataro, Robert C. Wolf |
MARC
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| 245 | 1 | 0 | |a Aberrant cortical neurodevelopment in major depressive disorder |c Mike M. Schmitgen, Malte S. Depping, Claudia Bach, Nadine D. Wolf, Katharina M. Kubera, Nenad Vasic, Dusan Hirjak, Fabio Sambataro, Robert C. Wolf |
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| 520 | |a Background - There is strong neuroimaging evidence that cortical alterations represent a core pathophysiological feature of major depressive disorder (MDD). Differential contributions of cortical features of neurodevelopmental origin, which may distinctly contribute to MDD vulnerability, disease-onset, or symptom expression, are unclear at present. - Methods - We investigated distinct markers of cortical neurodevelopment, i.e. local cortical gyrification (LGI) and thickness (CT) in patients with MDD (n=38) and healthy controls (HC, n=22) using 3 T structural magnetic resonance imaging data and surface-based data analysis techniques. CT and LGI were computed using the Computational Anatomy Toolbox (CAT12). Analyses were performed for the entire cortical surface followed by a complementary regions-of-interest approach. - Results - MDD patients showed significantly greater LGI in frontal, cingulate, parietal, temporal, and occipital regions compared to HC (FDR-corrected at p<0.05 using threshold-free cluster enhancement). No significant differences of CT were found. In the MDD-group, correlations were found between duration of illness in years and number of depressive episodes and LGI of frontal, temporal, and parietal regions (p<0.05). - Limitations - Main limitations are the relatively modest sample size and a cross-sectional study design. We did not control for early environmental factors potentially influencing neurodevelopment, such as childhood trauma. We report associations uncorrected for multiple comparisons. - Conclusions - The data suggest different local trajectories of cortical change in MDD. In addition, our data support the notion that aberrant cortical development may serve as a vulnerability marker of MDD, as well as a potential predictor of disease course. | ||
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| 650 | 4 | |a Depression | |
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| 650 | 4 | |a Vulnerability | |
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