Transcriptomic and epigenetic profiling of ‘diffuse midline gliomas, H3 K27M-mutant’ discriminate two subgroups based on the type of histone H3 mutated and not supratentorial or infratentorial location
Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of the midline harboring the same canonical mutation at the Lysine 27 of the histones H3 tail.
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
5 November 2018
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| In: |
Acta Neuropathologica Communications
Year: 2018, Volume: 6, Pages: 1-13 |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-018-0614-1 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1186/s40478-018-0614-1
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| Author Notes: | David Castel, Cathy Philippe, Thomas Kergrohen, Martin Sill, Jane Merlevede, Emilie Barret, Stéphanie Puget, Christian Sainte-Rose, Christof M. Kramm, Chris Jones, Pascale Varlet, Stefan M. Pfister, Jacques Grill, David T.W. Jones, Marie-Anne Debily |
| Summary: | Diffuse midline glioma (DMG), H3 K27M-mutant, is a new entity in the updated WHO classification grouping together diffuse intrinsic pontine gliomas and infiltrating glial neoplasms of the midline harboring the same canonical mutation at the Lysine 27 of the histones H3 tail. |
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| Item Description: | Gesehen am 01.04.2019 |
| Physical Description: | Online Resource |
| ISSN: | 2051-5960 |
| DOI: | 10.1186/s40478-018-0614-1 |