Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis
Background Primary sclerosing cholangitis is associated with an increased risk of biliary tract cancer. Carbohydrate antigen 19-9 (CA19-9) can be used to screen for these malignancies. Aim To perform a longitudinal analysis of CA19-9 in patients with primary sclerosing cholangitis. Methods We conduc...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
27 January 2019
|
| In: |
Alimentary pharmacology & therapeutics
Year: 2019, Jahrgang: 49, Heft: 6, Pages: 769-778 |
| ISSN: | 1365-2036 |
| DOI: | 10.1111/apt.15146 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1111/apt.15146 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.15146 
|
| Verfasserangaben: | Andreas Wannhoff, Maik Brune, Johannes Knierim, Karl Heinz Weiss, Christian Rupp, Daniel N. Gotthardt |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1662607059 | ||
| 003 | DE-627 | ||
| 005 | 20230426172430.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190401s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/apt.15146 |2 doi | |
| 035 | |a (DE-627)1662607059 | ||
| 035 | |a (DE-599)KXP1662607059 | ||
| 035 | |a (OCoLC)1341205768 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wannhoff, Andreas |d 1983- |e VerfasserIn |0 (DE-588)1045619833 |0 (DE-627)774667486 |0 (DE-576)39911095X |4 aut | |
| 245 | 1 | 0 | |a Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis |c Andreas Wannhoff, Maik Brune, Johannes Knierim, Karl Heinz Weiss, Christian Rupp, Daniel N. Gotthardt |
| 264 | 1 | |c 27 January 2019 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.04.2019 | ||
| 520 | |a Background Primary sclerosing cholangitis is associated with an increased risk of biliary tract cancer. Carbohydrate antigen 19-9 (CA19-9) can be used to screen for these malignancies. Aim To perform a longitudinal analysis of CA19-9 in patients with primary sclerosing cholangitis. Methods We conducted a retrospective analysis of CA19-9 values in patients who had primary sclerosing cholangitis, with and without biliary malignancy. We calculated the index of individuality and reference change value in patients who were cancer-free. Long-term analysis of CA19-9 in cancer-free patients was performed and we assessed the change of CA19-9 prior to diagnosis of cancer. Results We obtained 1818 CA19-9 values from 247 patients, including 32 with malignancy. Median CA19-9 in cancer-free individuals was 15.6 U/mL. The index of individuality was 0.37 and the reference change value was 46.23%. In cancer-free patients, no significant change in CA19-9 was observed at 1, 2, 5, 7, 10, 15, and 20 years after initial diagnosis of primary sclerosing cholangitis. In patients with biliary tract cancer, CA19-9 was higher at 3 months prior to diagnosis (P < 0.05) than at 6 months before diagnosis and was also higher than at 3 months prior to last follow-up in cancer-free patients (P < 0.05). In 92.9% of patients with biliary cancer, we found an increase in CA19-9 of >46.23% in the year prior to cancer diagnosis. Conclusions CA19-9 in patients with primary sclerosing cholangitis is highly individual, and the reference change value should be preferred to reference intervals. In this study, CA19-9 remained stable in patients who were cancer-free but increased early in those who developed biliary tract cancer. Regular CA19-9 measurement might improve early detection of these malignancies. | ||
| 700 | 1 | |a Brune, Maik |d 1974- |e VerfasserIn |0 (DE-588)130611883 |0 (DE-627)504641948 |0 (DE-576)298297930 |4 aut | |
| 700 | 1 | |a Knierim, Johannes |d 1925-2015 |e VerfasserIn |0 (DE-588)1110039905 |0 (DE-627)865210411 |0 (DE-576)475689615 |4 aut | |
| 700 | 1 | |a Weiss, Karl Heinz |d 1976- |e VerfasserIn |0 (DE-588)130069531 |0 (DE-627)489615465 |0 (DE-576)297980203 |4 aut | |
| 700 | 1 | |a Rupp, Christian |d 1982- |e VerfasserIn |0 (DE-588)1023613190 |0 (DE-627)718110765 |0 (DE-576)367149435 |4 aut | |
| 700 | 1 | |a Gotthardt, Daniel |d 1973- |e VerfasserIn |0 (DE-588)12903293X |0 (DE-627)387885137 |0 (DE-576)297458027 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Alimentary pharmacology & therapeutics |d Oxford : Blackwell Science, 1987 |g 49(2019), 6, Seite 769-778 |h Online-Ressource |w (DE-627)320425290 |w (DE-600)2003094-0 |w (DE-576)091140137 |x 1365-2036 |7 nnas |a Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis |
| 773 | 1 | 8 | |g volume:49 |g year:2019 |g number:6 |g pages:769-778 |g extent:10 |a Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis |
| 856 | 4 | 0 | |u https://doi.org/10.1111/apt.15146 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/apt.15146 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190401 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 12903293X |a Gotthardt, Daniel |m 12903293X:Gotthardt, Daniel |d 50000 |e 50000PG12903293X |k 0/50000/ |p 6 |y j | ||
| 998 | |g 1023613190 |a Rupp, Christian |m 1023613190:Rupp, Christian |d 910000 |d 910100 |e 910000PR1023613190 |e 910100PR1023613190 |k 0/910000/ |k 1/910000/910100/ |p 5 | ||
| 998 | |g 130069531 |a Weiss, Karl Heinz |m 130069531:Weiss, Karl Heinz |d 910000 |d 910100 |e 910000PW130069531 |e 910100PW130069531 |k 0/910000/ |k 1/910000/910100/ |p 4 | ||
| 998 | |g 1110039905 |a Knierim, Johannes |m 1110039905:Knierim, Johannes |p 3 | ||
| 998 | |g 130611883 |a Brune, Maik |m 130611883:Brune, Maik |d 910000 |d 910100 |e 910000PB130611883 |e 910100PB130611883 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1045619833 |a Wannhoff, Andreas |m 1045619833:Wannhoff, Andreas |d 50000 |e 50000PW1045619833 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1662607059 |e 3417589851 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"pages":"769-778","year":"2019","extent":"10","issue":"6","volume":"49","text":"49(2019), 6, Seite 769-778"},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"publisher":"Blackwell Science","dateIssuedKey":"1987","publisherPlace":"Oxford","dateIssuedDisp":"1987-"}],"language":["eng"],"title":[{"title":"Alimentary pharmacology & therapeutics","title_sort":"Alimentary pharmacology & therapeutics"}],"id":{"eki":["320425290"],"doi":["10.1111/(ISSN)1365-2036"],"zdb":["2003094-0"],"issn":["1365-2036"]},"disp":"Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitisAlimentary pharmacology & therapeutics","note":["Fortsetzung der Druck-Ausgabe","Gesehen am 25.03.2022","Ungezählte Beil.: Supplement"],"titleAlt":[{"title":"Alimentary pharmacology and therapeutics"}],"pubHistory":["1.1987 -"],"recId":"320425290"}],"physDesc":[{"extent":"10 S."}],"person":[{"roleDisplay":"VerfasserIn","family":"Wannhoff","role":"aut","display":"Wannhoff, Andreas","given":"Andreas"},{"role":"aut","display":"Brune, Maik","given":"Maik","family":"Brune","roleDisplay":"VerfasserIn"},{"given":"Johannes","role":"aut","display":"Knierim, Johannes","family":"Knierim","roleDisplay":"VerfasserIn"},{"family":"Weiss","roleDisplay":"VerfasserIn","role":"aut","display":"Weiss, Karl Heinz","given":"Karl Heinz"},{"display":"Rupp, Christian","role":"aut","given":"Christian","family":"Rupp","roleDisplay":"VerfasserIn"},{"given":"Daniel","display":"Gotthardt, Daniel","role":"aut","family":"Gotthardt","roleDisplay":"VerfasserIn"}],"name":{"displayForm":["Andreas Wannhoff, Maik Brune, Johannes Knierim, Karl Heinz Weiss, Christian Rupp, Daniel N. Gotthardt"]},"origin":[{"dateIssuedDisp":"27 January 2019","dateIssuedKey":"2019"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"note":["Gesehen am 01.04.2019"],"recId":"1662607059","id":{"doi":["10.1111/apt.15146"],"eki":["1662607059"]},"title":[{"title_sort":"Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis","title":"Longitudinal analysis of CA19-9 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis"}]} | ||
| SRT | |a WANNHOFFANLONGITUDIN2720 | ||