Pleiotropic effect of lipoprotein-apheresis on the soluble form of activated leukocyte cell adhesion molecule (sALCAM) in familial hypercholesterolaemia
Introduction/Background: Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 11, 2018
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| In: |
Experimental and clinical endocrinology & diabetes
Year: 2018, Jahrgang: 126, Pages: 1-5 |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/a-0630-0232 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1055/a-0630-0232 Verlag, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-0630-0232 
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| Verfasserangaben: | Rüdiger von Bauer, Dimitrios Oikonomou, Alba Sulaj, Stefan Kopf, Thomas Fleming, Gottfried Rudofsky, Peter Nawroth |
| Zusammenfassung: | Introduction/Background: Atherosclerosis is an inflammatory disorder in which several converging immune responses modulate and induce lipid accumulation in macrophages. Activated leukocyte cell adhesion molecule (ALCAM) has been described as a structural homologue of HDL-receptor and functions as a pattern recognition receptor (PRR), while its soluble form sALCAM is involved in ALCAM-dependent and -independent immune mechanisms. The aim of this study was to investigate the effect of aggressive removal of low density lipoprotein-cholesterol (LDL-C) and lipoprotein(a) (Lp [a]) by lipoprotein-apheresis (LA) on sALCAM and blood viscosity as well as to evaluate its association with lipoproteins and serum markers of inflammation. |
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| Beschreibung: | Gesehen am 01.04.2019 Epub ahead of print |
| Beschreibung: | Online Resource |
| ISSN: | 1439-3646 |
| DOI: | 10.1055/a-0630-0232 |