Biochemical recurrence of prostate cancer: initial results with (18F)PSMA-1007 PET/CT
Biochemical recurrence (BCR) is a concern for prostate cancer patients after local treatment. 68Ga-labeled prostate-specific membrane antigen (PSMA) ligands have significantly improved prostate cancer imaging. However, several 18F-labeled ligands that were developed as fluorinated tracers might pres...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
Feb. 1, 2018
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| In: |
Journal of nuclear medicine
Year: 2018, Volume: 59, Issue: 4, Pages: 632-635 |
| ISSN: | 2159-662X |
| DOI: | 10.2967/jnumed.117.196329 |
| Online Access: | Verlag, Volltext: https://doi.org/10.2967/jnumed.117.196329 Verlag, Volltext: http://jnm.snmjournals.org/content/59/4/632 
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| Author Notes: | Frederik L. Giesel, Leon Will, Claudia Kesch, Martin Freitag, Christophe Kremer, Jonas Merkle, Oliver C. Neels, Jens Cardinale, Boris Hadaschik, Markus Hohenfellner, Klaus Kopka, Uwe Haberkorn, and Clemens Kratochwil |
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| 245 | 1 | 0 | |a Biochemical recurrence of prostate cancer |b initial results with (18F)PSMA-1007 PET/CT |c Frederik L. Giesel, Leon Will, Claudia Kesch, Martin Freitag, Christophe Kremer, Jonas Merkle, Oliver C. Neels, Jens Cardinale, Boris Hadaschik, Markus Hohenfellner, Klaus Kopka, Uwe Haberkorn, and Clemens Kratochwil |
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| 520 | |a Biochemical recurrence (BCR) is a concern for prostate cancer patients after local treatment. 68Ga-labeled prostate-specific membrane antigen (PSMA) ligands have significantly improved prostate cancer imaging. However, several 18F-labeled ligands that were developed as fluorinated tracers might present advantages. In this study, we analyzed the potential of 18F-PSMA-1007 in patients with BCR. Methods: Twelve patients with BCR after local treatment underwent PET/CT scans 1 and 3 h after injection of 18F-PSMA-1007. Results: 18F-PSMA-1007 PET/CT detected lesions in 9 of 12 patients (75%). A significant difference was observed when comparing the tracer uptake in 18F-PSMA-1007-positive lesions 1 and 3 h after injection (median SUVmax, 7.00 vs. 11.34; P < 0.001; n = 76). Forty-four (88%) of 50 18F-PSMA-1007-positive lymph nodes had a short-axis diameter of less than 8 mm. Conclusion: In this pilot study, 18F-PSMA-1007 PET/CT presented high potential for localization of recurrent disease in prostate cancer patients with BCR. | ||
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