Stochastic dynamics of nanoparticle and virus uptake
The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake. Using a simple deterministic theory for this process, we first show that, for the same radi...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 February 2019
|
| In: |
Physical review letters
Year: 2019, Jahrgang: 122, Heft: 8 |
| ISSN: | 1079-7114 |
| DOI: | 10.1103/PhysRevLett.122.088102 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1103/PhysRevLett.122.088102 Verlag, Volltext: https://link.aps.org/doi/10.1103/PhysRevLett.122.088102 
|
| Verfasserangaben: | Felix Frey, Falko Ziebert, and Ulrich S. Schwarz |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1662956630 | ||
| 003 | DE-627 | ||
| 005 | 20220816132133.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190408s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1103/PhysRevLett.122.088102 |2 doi | |
| 035 | |a (DE-627)1662956630 | ||
| 035 | |a (DE-599)KXP1662956630 | ||
| 035 | |a (OCoLC)1341207933 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 29 |2 sdnb | ||
| 100 | 1 | |a Frey, Felix |d 1989- |e VerfasserIn |0 (DE-588)1147590249 |0 (DE-627)1006338969 |0 (DE-576)495880213 |4 aut | |
| 245 | 1 | 0 | |a Stochastic dynamics of nanoparticle and virus uptake |c Felix Frey, Falko Ziebert, and Ulrich S. Schwarz |
| 264 | 1 | |c 26 February 2019 | |
| 300 | |a 5 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 08.04.2019 | ||
| 520 | |a The cellular uptake of nanoparticles or viruses requires that the gain of adhesion energy overcomes the cost of plasma membrane bending. It is well known that this leads to a minimal particle size for uptake. Using a simple deterministic theory for this process, we first show that, for the same radius and volume, cylindrical particles should be taken up faster than spherical particles, both for normal and parallel orientations. We then address stochastic effects, which are expected to be relevant due to small system size, and show that, now, spherical particles can have a faster uptake because the mean first passage time profits from the multiplicative noise induced by the spherical geometry. We conclude that stochastic effects are strongly geometry dependent and may favor spherical shapes during adhesion-driven particle uptake. | ||
| 700 | 1 | |a Ziebert, Falko |d 1976- |e VerfasserIn |0 (DE-588)1147603618 |0 (DE-627)100634750X |0 (DE-576)495886017 |4 aut | |
| 700 | 1 | |a Schwarz, Ulrich S. |d 1966- |e VerfasserIn |0 (DE-588)120379473 |0 (DE-627)080637280 |0 (DE-576)297582763 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physical review letters |d College Park, Md. : APS, 1958 |g 122(2019,8) Artikel-Nummer 088102, 5 Seiten |h Online-Ressource |w (DE-627)268756899 |w (DE-600)1472655-5 |w (DE-576)077609441 |x 1079-7114 |7 nnas |a Stochastic dynamics of nanoparticle and virus uptake |
| 773 | 1 | 8 | |g volume:122 |g year:2019 |g number:8 |g extent:5 |a Stochastic dynamics of nanoparticle and virus uptake |
| 856 | 4 | 0 | |u https://doi.org/10.1103/PhysRevLett.122.088102 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://link.aps.org/doi/10.1103/PhysRevLett.122.088102 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190408 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 120379473 |a Schwarz, Ulrich S. |m 120379473:Schwarz, Ulrich S. |d 130000 |d 130300 |d 700000 |d 716000 |e 130000PS120379473 |e 130300PS120379473 |e 700000PS120379473 |e 716000PS120379473 |k 0/130000/ |k 1/130000/130300/ |k 0/700000/ |k 1/700000/716000/ |p 3 |y j | ||
| 998 | |g 1147603618 |a Ziebert, Falko |m 1147603618:Ziebert, Falko |d 130000 |d 130300 |d 700000 |d 716000 |e 130000PZ1147603618 |e 130300PZ1147603618 |e 700000PZ1147603618 |e 716000PZ1147603618 |k 0/130000/ |k 1/130000/130300/ |k 0/700000/ |k 1/700000/716000/ |p 2 | ||
| 998 | |g 1147590249 |a Frey, Felix |m 1147590249:Frey, Felix |d 130000 |d 130300 |d 700000 |d 716000 |e 130000PF1147590249 |e 130300PF1147590249 |e 700000PF1147590249 |e 716000PF1147590249 |k 0/130000/ |k 1/130000/130300/ |k 0/700000/ |k 1/700000/716000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1662956630 |e 342100322X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"Stochastic dynamics of nanoparticle and virus uptake","title_sort":"Stochastic dynamics of nanoparticle and virus uptake"}],"name":{"displayForm":["Felix Frey, Falko Ziebert, and Ulrich S. Schwarz"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1103/PhysRevLett.122.088102"],"eki":["1662956630"]},"person":[{"given":"Felix","display":"Frey, Felix","role":"aut","family":"Frey"},{"family":"Ziebert","display":"Ziebert, Falko","role":"aut","given":"Falko"},{"given":"Ulrich S.","family":"Schwarz","display":"Schwarz, Ulrich S.","role":"aut"}],"origin":[{"dateIssuedDisp":"26 February 2019","dateIssuedKey":"2019"}],"language":["eng"],"note":["Gesehen am 08.04.2019"],"recId":"1662956630","physDesc":[{"extent":"5 S."}],"relHost":[{"origin":[{"dateIssuedDisp":"1958-","publisherPlace":"College Park, Md.","dateIssuedKey":"1958","publisher":"APS"}],"part":{"year":"2019","text":"122(2019,8) Artikel-Nummer 088102, 5 Seiten","issue":"8","extent":"5","volume":"122"},"id":{"zdb":["1472655-5"],"issn":["1079-7114"],"eki":["268756899"]},"name":{"displayForm":["publ. by the American Physical Society"]},"disp":"Stochastic dynamics of nanoparticle and virus uptakePhysical review letters","title":[{"title":"Physical review letters","title_sort":"Physical review letters"}],"language":["eng"],"pubHistory":["1.1958 -"],"titleAlt":[{"title":"Physical review letters online"},{"title":"Physical review L"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"268756899","note":["Gesehen am 23.08.2019"],"corporate":[{"role":"isb","display":"American Physical Society"}]}]} | ||
| SRT | |a FREYFELIXZSTOCHASTIC2620 | ||