Cellular TRIM33 restrains HIV-1 infection by targeting viral integrase for proteasomal degradation
HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration by triggering IN proteasome-mediated degradation.
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
25 February 2019
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| In: |
Nature Communications
Year: 2019, Jahrgang: 10 |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-08810-0 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/s41467-019-08810-0 Verlag, Volltext: https://www.nature.com/articles/s41467-019-08810-0 
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| Verfasserangaben: | Hashim Ali, Miguel Mano, Luca Braga, Asma Naseem, Bruna Marini, Diem My Vu, Chiara Collesi, Germana Meroni, Marina Lusic & Mauro Giacca |
| Zusammenfassung: | HIV-1 integration into host DNA is mediated by the viral integrase (IN). Here, using siRNA screen and high-content microscopy, the authors identify the host E3 RING ligase TRIM33 to affect IN stability and show that TRIM33 prevents viral integration by triggering IN proteasome-mediated degradation. |
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| Beschreibung: | Gesehen am 10.04.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-019-08810-0 |