Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer
Background: While intensity modulated radiotherapy (IMRT) in anal cancer is feasible and improves high-dose conformality, the current RTOG/AGITG contouring atlas and planning guidelines lack specific instructions on how to proceed with external genitalia. Meanwhile, the RTOG-Protocol 0529 explicitly...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 April 2016
|
| In: |
Radiation oncology
Year: 2016, Volume: 11 |
| ISSN: | 1748-717X |
| DOI: | 10.1186/s13014-016-0628-4 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13014-016-0628-4 Verlag, kostenfrei, Volltext: https://ro-journal.biomedcentral.com/articles/10.1186/s13014-016-0628-4 
|
| Author Notes: | Julia Koeck, Frank Lohr, Daniel Buergy, Karen Büsing, Marcus J. Trunk, Frederik Wenz and Sabine Mai |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1663116881 | ||
| 003 | DE-627 | ||
| 005 | 20230426154307.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190411s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1186/s13014-016-0628-4 |2 doi | |
| 035 | |a (DE-627)1663116881 | ||
| 035 | |a (DE-599)KXP1663116881 | ||
| 035 | |a (OCoLC)1341209475 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Köck, Julia |d 1986- |e VerfasserIn |0 (DE-588)1031503900 |0 (DE-627)736544674 |0 (DE-576)378966138 |4 aut | |
| 245 | 1 | 0 | |a Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer |c Julia Koeck, Frank Lohr, Daniel Buergy, Karen Büsing, Marcus J. Trunk, Frederik Wenz and Sabine Mai |
| 264 | 1 | |c 04 April 2016 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 11.04.2019 | ||
| 520 | |a Background: While intensity modulated radiotherapy (IMRT) in anal cancer is feasible and improves high-dose conformality, the current RTOG/AGITG contouring atlas and planning guidelines lack specific instructions on how to proceed with external genitalia. Meanwhile, the RTOG-Protocol 0529 explicitly recommends genital sparing on the basis of specific genital dose constraints. Recent pattern-of-relapse studies based on conventional techniques suggest that marginal miss might be a potential consequence of genital sparing. Our goal is to outline the potential scope and increase the awareness for this clinical issue. Methods: We present and discuss four patients with perigenital spread in anal cancer in both early and advanced stages (three at time of first diagnosis and one in form of relapse). Genital/perigenital spread was observed once as direct genital infiltration and thrice in form of perigenital lymphatic spread. Results: We review the available data regarding the potential consequences of genital sparing in anal cancer. Pattern-of-relapse studies in anal cancer after conventional radiotherapy and the current use of IMRT in anal cancer are equivocal but suggest that genital sparing may occasionally result in marginal miss. An obvious hypothesis suggested by our report is that perigenital lymphovascular invasion might be associated with manifest inguinal N+ disease. Conclusions: Local failure has low salvage rates in recent anal cancer treatment series. Perigenital spread may pose a risk of marginal misses in IMRT in anal cancer. To prevent marginal misses, meticulous pattern-of-relapse analyses of controlled IMRT-series are warranted. Until their publication, genital sparing should be applied with caution, PET/CT should be used when possible and meeting genital dose constraints should not be prioritized over CTV coverage, especially (but not only) in stage T3/4 and N+ disease. | ||
| 700 | 1 | |a Lohr, Frank |e VerfasserIn |0 (DE-588)1025307194 |0 (DE-627)72201967X |0 (DE-576)37018694X |4 aut | |
| 700 | 1 | |a Bürgy, Daniel |d 1980- |e VerfasserIn |0 (DE-588)141653779 |0 (DE-627)630406472 |0 (DE-576)325119031 |4 aut | |
| 700 | 1 | |a Büsing, Karen-Anett |d 1970- |e VerfasserIn |0 (DE-588)123814634 |0 (DE-627)706436032 |0 (DE-576)293891222 |4 aut | |
| 700 | 1 | |a Wenz, Frederik |d 1966- |e VerfasserIn |0 (DE-588)113310390 |0 (DE-627)663837766 |0 (DE-576)346656281 |4 aut | |
| 700 | 1 | |a Mai, Sabine |d 1964- |e VerfasserIn |0 (DE-588)1048197883 |0 (DE-627)779968042 |0 (DE-576)402013913 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiation oncology |d London : BioMed Central, 2006 |g 11(2016) Artikel-Nummer 53, 8 Seiten |h Online-Ressource |w (DE-627)508725739 |w (DE-600)2224965-5 |w (DE-576)260614815 |x 1748-717X |7 nnas |a Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer |
| 773 | 1 | 8 | |g volume:11 |g year:2016 |g extent:8 |a Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1186/s13014-016-0628-4 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://ro-journal.biomedcentral.com/articles/10.1186/s13014-016-0628-4 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190411 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1048197883 |a Mai, Sabine |m 1048197883:Mai, Sabine |d 60000 |d 63000 |e 60000PM1048197883 |e 63000PM1048197883 |k 0/60000/ |k 1/60000/63000/ |p 7 |y j | ||
| 998 | |g 113310390 |a Wenz, Frederik |m 113310390:Wenz, Frederik |d 60000 |d 63000 |e 60000PW113310390 |e 63000PW113310390 |k 0/60000/ |k 1/60000/63000/ |p 6 | ||
| 998 | |g 123814634 |a Büsing, Karen-Anett |m 123814634:Büsing, Karen-Anett |d 60000 |d 62900 |e 60000PB123814634 |e 62900PB123814634 |k 0/60000/ |k 1/60000/62900/ |p 4 | ||
| 998 | |g 141653779 |a Bürgy, Daniel |m 141653779:Bürgy, Daniel |d 60000 |d 63000 |e 60000PB141653779 |e 63000PB141653779 |k 0/60000/ |k 1/60000/63000/ |p 3 | ||
| 998 | |g 1025307194 |a Lohr, Frank |m 1025307194:Lohr, Frank |d 60000 |d 63000 |e 60000PL1025307194 |e 63000PL1025307194 |k 0/60000/ |k 1/60000/63000/ |p 2 | ||
| 999 | |a KXP-PPN1663116881 |e 3421385661 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"04 April 2016","dateIssuedKey":"2016"}],"physDesc":[{"extent":"8 S."}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer","title_sort":"Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancer"}],"language":["eng"],"name":{"displayForm":["Julia Koeck, Frank Lohr, Daniel Buergy, Karen Büsing, Marcus J. Trunk, Frederik Wenz and Sabine Mai"]},"id":{"doi":["10.1186/s13014-016-0628-4"],"eki":["1663116881"]},"person":[{"family":"Köck","display":"Köck, Julia","role":"aut","roleDisplay":"VerfasserIn","given":"Julia"},{"roleDisplay":"VerfasserIn","role":"aut","display":"Lohr, Frank","family":"Lohr","given":"Frank"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Bürgy","display":"Bürgy, Daniel","given":"Daniel"},{"given":"Karen-Anett","family":"Büsing","display":"Büsing, Karen-Anett","role":"aut","roleDisplay":"VerfasserIn"},{"given":"Frederik","role":"aut","roleDisplay":"VerfasserIn","family":"Wenz","display":"Wenz, Frederik"},{"given":"Sabine","family":"Mai","display":"Mai, Sabine","role":"aut","roleDisplay":"VerfasserIn"}],"relHost":[{"note":["Gesehen am 06.09.10"],"recId":"508725739","id":{"eki":["508725739"],"zdb":["2224965-5"],"issn":["1748-717X"]},"disp":"Genital invasion or perigenital spread may pose a risk of marginal misses for Intensity Modulated Radiotherapy (IMRT) in anal cancerRadiation oncology","language":["eng"],"title":[{"title_sort":"Radiation oncology","title":"Radiation oncology"}],"pubHistory":["1.2006 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"volume":"11","extent":"8","year":"2016","text":"11(2016) Artikel-Nummer 53, 8 Seiten"},"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"publisherPlace":"London","publisher":"BioMed Central","dateIssuedKey":"2006","dateIssuedDisp":"2006-"}]}],"recId":"1663116881","note":["Gesehen am 11.04.2019"]} | ||
| SRT | |a KOECKJULIAGENITALINV0420 | ||