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Cryo-EM structure of a light chain-derived amyloid fibril from a patient with systemic AL amyloidosis

Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolated from an explanted human heart.

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Bibliographische Detailangaben
Hauptverfasser: Radamaker, Lynn (VerfasserIn) , Huhn, Stefanie (VerfasserIn) , Hegenbart, Ute (VerfasserIn) , Schönland, Stefan (VerfasserIn) , Fritz, Günter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 20 March 2019
In: Nature Communications
Year: 2019, Jahrgang: 10
ISSN:2041-1723
DOI:10.1038/s41467-019-09032-0
Online-Zugang:Verlag, Volltext: https://doi.org/10.1038/s41467-019-09032-0
Verlag, Volltext: https://www.nature.com/articles/s41467-019-09032-0
Volltext
Verfasserangaben:Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt & Marcus Fändrich

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