Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid
The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reacti...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 February 2018
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| In: |
Monatshefte für Chemie
Year: 2018, Volume: 149, Issue: 3, Pages: 625-633 |
| ISSN: | 1434-4475 |
| DOI: | 10.1007/s00706-017-2086-6 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1007/s00706-017-2086-6
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| Author Notes: | Sorour Ramezanpour, Akram Panahi, Frank Rominger |
MARC
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| 520 | |a The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reaction, and excellent yields are some advantages of this protocol.Graphical abstract Open image in new window | ||
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