Diastereoselective synthesis of peptidomimetics in one-pot Ugi reaction using trans-4-isopropylcyclohexanecarboxylic acid
The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reacti...
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| Autori principali: | , , |
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| Natura: | Article (Journal) |
| Lingua: | inglese |
| Pubblicazione: |
01 February 2018
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| In: |
Monatshefte für Chemie
Year: 2018, Volume: 149, Fascicolo: 3, Pages: 625-633 |
| ISSN: | 1434-4475 |
| DOI: | 10.1007/s00706-017-2086-6 |
| Accesso online: | Verlag, Volltext: https://doi.org/10.1007/s00706-017-2086-6
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| Note sull'autore: | Sorour Ramezanpour, Akram Panahi, Frank Rominger |
| Riassunto: | The use of trans-4-isopropylcyclohexanecarboxylic acid as a substitution for the carboxylic acid component in the Ugi multicomponent condensation that leads to (1R,4R)-N-(2-(cyclohexylamino)-2-oxo-4-isopropylcyclohexane-1-carboxamide derivatives is described for the first time. One pot, clean reaction, and excellent yields are some advantages of this protocol.Graphical abstract Open image in new window |
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| Descrizione del documento: | Gesehen am 15.04.2019 |
| Descrizione fisica: | Online Resource |
| ISSN: | 1434-4475 |
| DOI: | 10.1007/s00706-017-2086-6 |