Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses
Suppressor of cytokine signaling (SOCS) proteins serve as negative regulators of cytokine receptor signaling. However, SOCS proteins are not only induced via the JAK/STAT pathway, but are also transcribed on triggering of pattern recognition receptors such as TLRs. We now show that SOCS1 can also be...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
30 April 2012
|
| In: |
The journal of immunology
Year: 2012, Volume: 188, Issue: 11, Pages: 5644-5654 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.1103068 |
| Online Access: | Verlag, Volltext: https://doi.org/10.4049/jimmunol.1103068 Verlag, Volltext: http://www.jimmunol.org/content/188/11/5644 
|
| Author Notes: | Mariel E. Eberle and Alexander H. Dalpke |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1663283702 | ||
| 003 | DE-627 | ||
| 005 | 20220816134715.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190416s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4049/jimmunol.1103068 |2 doi | |
| 035 | |a (DE-627)1663283702 | ||
| 035 | |a (DE-599)KXP1663283702 | ||
| 035 | |a (OCoLC)1341209692 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Eberle, Mariel-Esther |e VerfasserIn |0 (DE-588)1024722244 |0 (DE-627)720417236 |0 (DE-576)369401727 |4 aut | |
| 245 | 1 | 0 | |a Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses |c Mariel E. Eberle and Alexander H. Dalpke |
| 264 | 1 | |c 30 April 2012 | |
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.04.219 | ||
| 520 | |a Suppressor of cytokine signaling (SOCS) proteins serve as negative regulators of cytokine receptor signaling. However, SOCS proteins are not only induced via the JAK/STAT pathway, but are also transcribed on triggering of pattern recognition receptors such as TLRs. We now show that SOCS1 can also be induced by the non-TLR pattern recognition receptor Dectin-1 in murine bone marrow-derived dendritic cells and macrophages (BMMs). The C-type lectin Dectin-1 binds to yeasts and signals either in an autonomous manner or can be triggered in combination with TLRs. In our study, SOCS1 was expressed independently of any TLR engagement as a direct target gene of the Dectin-1 ligand Zymosan. Induction of SOCS1 was mediated by a novel pathway encompassing the tyrosine kinases Src and Syk that activated the downstream kinase proline-rich tyrosine kinase 2. Proline-rich tyrosine kinase 2, in turn, caused activation of the MAPK ERK, thereby triggering SOCS1 induction. SOCS1 did not modulate Dectin-1 signaling but affected TLR signaling, leading to decreased and abbreviated NF-κB activation in BMMs triggered by TLR9. Furthermore, IL-12 and IL-10 secretion were inhibited by SOCS1. We additionally observed that IL-17-producing Th cells were clearly increased by SOCS1 in BMMs. Our results show that SOCS1 is expressed via a new, NF-κB-independent pathway in Dectin-1-triggered murine BMMs and influences TLR cross talk and T cell priming. | ||
| 650 | 4 | |a Animals | |
| 650 | 4 | |a Bone Marrow Cells | |
| 650 | 4 | |a Cell Differentiation | |
| 650 | 4 | |a Cells, Cultured | |
| 650 | 4 | |a Gene Knockdown Techniques | |
| 650 | 4 | |a Lectins, C-Type | |
| 650 | 4 | |a Macrophages | |
| 650 | 4 | |a Mice | |
| 650 | 4 | |a Mice, Inbred C57BL | |
| 650 | 4 | |a Mice, Knockout | |
| 650 | 4 | |a NF-kappa B | |
| 650 | 4 | |a Receptor Cross-Talk | |
| 650 | 4 | |a Signal Transduction | |
| 650 | 4 | |a Suppressor of Cytokine Signaling 1 Protein | |
| 650 | 4 | |a Suppressor of Cytokine Signaling Proteins | |
| 650 | 4 | |a T-Lymphocyte Subsets | |
| 650 | 4 | |a Toll-Like Receptors | |
| 700 | 1 | |a Dalpke, Alexander |d 1971- |e VerfasserIn |0 (DE-588)123821878 |0 (DE-627)706438523 |0 (DE-576)293894272 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of immunology |d Rockville, Md. : American Association of Immunologists, 1916 |g 188(2012), 11, Seite 5644-5654 |h Online-Ressource |w (DE-627)269535217 |w (DE-600)1475085-5 |w (DE-576)079963838 |x 1550-6606 |7 nnas |a Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses |
| 773 | 1 | 8 | |g volume:188 |g year:2012 |g number:11 |g pages:5644-5654 |g extent:11 |a Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses |
| 856 | 4 | 0 | |u https://doi.org/10.4049/jimmunol.1103068 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.jimmunol.org/content/188/11/5644 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190416 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1024722244 |a Eberle, Mariel-Esther |m 1024722244:Eberle, Mariel-Esther |d 910000 |d 911700 |e 910000PE1024722244 |e 911700PE1024722244 |k 0/910000/ |k 1/910000/911700/ |p 2 |y j | ||
| 998 | |g 123821878 |a Dalpke, Alexander |m 123821878:Dalpke, Alexander |d 910000 |d 911700 |e 910000PD123821878 |e 911700PD123821878 |k 0/910000/ |k 1/910000/911700/ |p 1 |x j | ||
| 999 | |a KXP-PPN1663283702 |e 3422523480 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Eberle, Mariel-Esther","role":"aut","given":"Mariel-Esther","roleDisplay":"VerfasserIn","family":"Eberle"},{"given":"Alexander","display":"Dalpke, Alexander","role":"aut","family":"Dalpke","roleDisplay":"VerfasserIn"}],"note":["Gesehen am 16.04.219"],"physDesc":[{"extent":"11 S."}],"relHost":[{"disp":"Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responsesThe journal of immunology","title":[{"title":"The journal of immunology","title_sort":"journal of immunology"}],"recId":"269535217","pubHistory":["1.1916 -"],"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"American Association of Immunologists"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["American Association of Immunologists"]},"part":{"year":"2012","pages":"5644-5654","text":"188(2012), 11, Seite 5644-5654","extent":"11","issue":"11","volume":"188"},"note":["Gesehen am 18.08.2025"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["269535217"],"issn":["1550-6606"],"zdb":["1475085-5"]},"origin":[{"publisher":"Oxford University Press ; Soc. ; American Association of Immunologists","dateIssuedKey":"2025","dateIssuedDisp":"2025-","publisherPlace":"Oxford ; Bethesda, Md. ; Rockville, Md."}]}],"id":{"eki":["1663283702"],"doi":["10.4049/jimmunol.1103068"]},"origin":[{"dateIssuedDisp":"30 April 2012","dateIssuedKey":"2012"}],"title":[{"title":"Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses","title_sort":"Dectin-1 stimulation induces suppressor of cytokine signaling 1, thereby modulating TLR signaling and T cell responses"}],"recId":"1663283702","type":{"bibl":"article-journal","media":"Online-Ressource"},"language":["eng"],"name":{"displayForm":["Mariel E. Eberle and Alexander H. Dalpke"]}} | ||
| SRT | |a EBERLEMARIDECTIN1STI3020 | ||