Alpha-synuclein’s degradation in vivo
Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we re...
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| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
01 Feb 2012
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| In: |
Autophagy
Year: 2012, Volume: 8, Issue: 2, Pages: 281-283 |
| ISSN: | 1554-8635 |
| DOI: | 10.4161/auto.8.2.18938 |
| Online Access: | Verlag, Volltext: https://doi.org/10.4161/auto.8.2.18938
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| Author Notes: | Darius Ebrahimi-Fakhari, Pamela J. McLean & Vivek K. Unni |
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| 520 | |a Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in α-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease. | ||
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