Alpha-synuclein’s degradation in vivo
Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we re...
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| Hauptverfasser: | , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
01 Feb 2012
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| In: |
Autophagy
Year: 2012, Jahrgang: 8, Heft: 2, Pages: 281-283 |
| ISSN: | 1554-8635 |
| DOI: | 10.4161/auto.8.2.18938 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.4161/auto.8.2.18938
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| Verfasserangaben: | Darius Ebrahimi-Fakhari, Pamela J. McLean & Vivek K. Unni |
| Zusammenfassung: | Progressive accumulation of α-synuclein is key to the pathology of many neurodegenerative diseases, including Parkinson disease and dementia with Lewy bodies. Increased intracellular levels of α-synuclein may be caused by enhanced expression or alterations in protein degradation pathways. Here we review our recent study showing that the ubiquitin-proteasome system and the autophagy-lysosomal pathway are differentially involved in α-synuclein's degradation in vivo. We discuss the key findings obtained with our novel in vivo approach and also present a model for the progression of protein aggregation and dysfunctional degradation in Parkinson disease. |
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| Beschreibung: | Gesehen am 16.04.2019 |
| Beschreibung: | Online Resource |
| ISSN: | 1554-8635 |
| DOI: | 10.4161/auto.8.2.18938 |