TFAP2E-DKK4 and chemoresistance in colorectal cancer
To the Editor: Ebert et al. (Jan. 5 issue)1 report that hypermethylation of the gene encoding transcription factor AP-2 epsilon (TFAP2E) reduces its expression and is associated with chemoresistance in patients with colorectal cancer and in colorectal-cancer cell lines in vitro. The test has dramati...
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
March 8, 2012
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| In: |
The New England journal of medicine
Year: 2012, Volume: 366, Issue: 10, Pages: 966-966 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMc1201170 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1056/NEJMc1201170
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| Author Notes: | Matthias P.A. Ebert, M.D., Marc Tänzer, M.A. |
MARC
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| 520 | |a To the Editor: Ebert et al. (Jan. 5 issue)1 report that hypermethylation of the gene encoding transcription factor AP-2 epsilon (TFAP2E) reduces its expression and is associated with chemoresistance in patients with colorectal cancer and in colorectal-cancer cell lines in vitro. The test has dramatic clinical value: the response rate increased from less than 15% among hypomethylated tumors to more than 80% among hypermethylated tumors. Methylation of this gene had a huge biologic and clinical effect. However, we have several questions. First, the methylation status differs between primary tumors and metastases in approximately 30% of tumors: were these tumors considered . . . | ||
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