High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations
To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism-array analysis using Affymetrix Version 6.0 on 353 samples from untreated patients entered in the CLL8 treatment trial. Based on paired-sample analysis (n = 144), a mean of 1.8 copy num...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 09, 2012
|
| In: |
Blood
Year: 2012, Jahrgang: 120, Heft: 24, Pages: 4783-4794 |
| ISSN: | 1528-0020 |
| DOI: | 10.1182/blood-2012-04-423517 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1182/blood-2012-04-423517 Verlag, Volltext: http://www.bloodjournal.org/content/120/24/4783 
|
| Verfasserangaben: | Jennifer Edelmann, Karlheinz Holzmann, Florian Miller, Dirk Winkler, Andreas Bühler, Thorsten Zenz, Lars Bullinger, Michael W. M. Kühn, Andreas Gerhardinger, Johannes Bloehdorn, Ina Radtke, Xiaoping Su, Jing Ma, Stanley Pounds, Michael Hallek, Peter Lichter, Jan Korbel, Raymonde Busch, Daniel Mertens, James R. Downing, Stephan Stilgenbauer, and Hartmut Döhner |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 166344093X | ||
| 003 | DE-627 | ||
| 005 | 20220816135919.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190418s2012 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1182/blood-2012-04-423517 |2 doi | |
| 035 | |a (DE-627)166344093X | ||
| 035 | |a (DE-599)KXP166344093X | ||
| 035 | |a (OCoLC)1341209577 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Edelmann, Jennifer |d 1980- |e VerfasserIn |0 (DE-588)1023576406 |0 (DE-627)718412079 |0 (DE-576)367019396 |4 aut | |
| 245 | 1 | 0 | |a High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations |c Jennifer Edelmann, Karlheinz Holzmann, Florian Miller, Dirk Winkler, Andreas Bühler, Thorsten Zenz, Lars Bullinger, Michael W. M. Kühn, Andreas Gerhardinger, Johannes Bloehdorn, Ina Radtke, Xiaoping Su, Jing Ma, Stanley Pounds, Michael Hallek, Peter Lichter, Jan Korbel, Raymonde Busch, Daniel Mertens, James R. Downing, Stephan Stilgenbauer, and Hartmut Döhner |
| 264 | 1 | |c October 09, 2012 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.04.2019 | ||
| 520 | |a To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism-array analysis using Affymetrix Version 6.0 on 353 samples from untreated patients entered in the CLL8 treatment trial. Based on paired-sample analysis (n = 144), a mean of 1.8 copy number alterations per patient were identified; approximately 60% of patients carried no copy number alterations other than those detected by fluorescence in situ hybridization analysis. Copy-neutral loss-of-heterozygosity was detected in 6% of CLL patients and was found most frequently on 13q, 17p, and 11q. Minimally deleted regions were refined on 13q14 (deleted in 61% of patients) to the DLEU1 and DLEU2 genes, on 11q22.3 (27% of patients) to ATM, on 2p16.1-2p15 (gained in 7% of patients) to a 1.9-Mb fragment containing 9 genes, and on 8q24.21 (5% of patients) to a segment 486 kb proximal to the MYC locus. 13q deletions exhibited proximal and distal breakpoint cluster regions. Among the most common novel lesions were deletions at 15q15.1 (4% of patients), with the smallest deletion (70.48 kb) found in the MGA locus. Sequence analysis of MGA in 59 samples revealed a truncating mutation in one CLL patient lacking a 15q deletion. MNT at 17p13.3, which in addition to MGA and MYC encodes for the network of MAX-interacting proteins, was also deleted recurrently. | ||
| 700 | 1 | |a Zenz, Thorsten |d 1970- |e VerfasserIn |0 (DE-588)114963738 |0 (DE-627)577184202 |0 (DE-576)180278266 |4 aut | |
| 700 | 1 | |a Lichter, Peter |d 1957- |e VerfasserIn |0 (DE-588)1096366282 |0 (DE-627)856749915 |0 (DE-576)468019049 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Blood |d Washington, DC : American Society of Hematology, 1946 |g 120(2012), 24, Seite 4783-4794 |h Online-Ressource |w (DE-627)266886647 |w (DE-600)1468538-3 |w (DE-576)075961938 |x 1528-0020 |7 nnas |a High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations |
| 773 | 1 | 8 | |g volume:120 |g year:2012 |g number:24 |g pages:4783-4794 |g extent:12 |a High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations |
| 856 | 4 | 0 | |u https://doi.org/10.1182/blood-2012-04-423517 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://www.bloodjournal.org/content/120/24/4783 |x Verlag |x Resolving-System |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190418 | ||
| 993 | |a Article | ||
| 994 | |a 2012 | ||
| 998 | |g 1096366282 |a Lichter, Peter |m 1096366282:Lichter, Peter |d 50000 |e 50000PL1096366282 |k 0/50000/ |p 16 | ||
| 998 | |g 114963738 |a Zenz, Thorsten |m 114963738:Zenz, Thorsten |p 6 | ||
| 999 | |a KXP-PPN166344093X |e 3422939644 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"title":"High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations","title_sort":"High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations"}],"language":["eng"],"name":{"displayForm":["Jennifer Edelmann, Karlheinz Holzmann, Florian Miller, Dirk Winkler, Andreas Bühler, Thorsten Zenz, Lars Bullinger, Michael W. M. Kühn, Andreas Gerhardinger, Johannes Bloehdorn, Ina Radtke, Xiaoping Su, Jing Ma, Stanley Pounds, Michael Hallek, Peter Lichter, Jan Korbel, Raymonde Busch, Daniel Mertens, James R. Downing, Stephan Stilgenbauer, and Hartmut Döhner"]},"person":[{"family":"Edelmann","display":"Edelmann, Jennifer","given":"Jennifer","role":"aut"},{"family":"Zenz","role":"aut","given":"Thorsten","display":"Zenz, Thorsten"},{"display":"Lichter, Peter","given":"Peter","role":"aut","family":"Lichter"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"recId":"166344093X","origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"October 09, 2012"}],"physDesc":[{"extent":"12 S."}],"id":{"doi":["10.1182/blood-2012-04-423517"],"eki":["166344093X"]},"note":["Gesehen am 18.04.2019"],"relHost":[{"origin":[{"publisherPlace":"Washington, DC ; Philadelphia, Pa. ; Stanford, Calif.","publisher":"American Society of Hematology ; Saunders ; HighWire Press","dateIssuedDisp":"1946-","dateIssuedKey":"1946"}],"recId":"266886647","type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"Blood online"}],"disp":"High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterationsBlood","id":{"issn":["1528-0020"],"zdb":["1468538-3"],"eki":["266886647"]},"physDesc":[{"extent":"Online-Ressource"}],"corporate":[{"role":"isb","display":"American Society of Hematology"}],"note":["Gesehen am 21.04.2023"],"title":[{"title_sort":"Blood","subtitle":"journal of the American Society of Hematology","title":"Blood"}],"part":{"issue":"24","pages":"4783-4794","extent":"12","text":"120(2012), 24, Seite 4783-4794","year":"2012","volume":"120"},"language":["eng"],"pubHistory":["1.1946 -"]}]} | ||
| SRT | |a EDELMANNJEHIGHRESOLU0920 | ||