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Impact of carbonylation on glutathione peroxidase-1 activity in human hyperglycemic endothelial cells

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Aims - High levels of glucose and reactive carbonyl intermediates of its degradation pathway such as methylglyoxal (MG) may contribute to diabetic complications partly via increased generation of reactive oxygen species (ROS). This study focused on glutathione peroxidase-1 (GPx1) expression and the...

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Main Authors: Sultan, Cheryl Sophia (Author) , Saackel, Andrea (Author) , Stank, Antonia (Author) , Fleming, Thomas (Author) , Wade, Rebecca C. (Author) , Hecker, Markus (Author) , Wagner, Andreas H. (Author)
Format: Article (Journal)
Language:English
Published: 01 March 2018
In: Redox Biology
Year: 2018, Volume: 16, Pages: 113-122
ISSN:2213-2317
DOI:10.1016/j.redox.2018.02.018
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.redox.2018.02.018
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S2213231718300533
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Author Notes:Cheryl S. Sultan, Andrea Saackel, Antonia Stank, Thomas Fleming, Maria Fedorova, Ralf Hoffmann, Rebecca C. Wade, Markus Hecker, Andreas H. Wagner
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C332C genotype of glyoxalase 1 and its association with late diabetic complications: Glo1 genotype and diabetic neuropathy by Gröner, Jan (Author) , Reismann, Peter (Author) , Fleming, Thomas (Author) , Kalscheuer, Hannes (Author) , Lehnhoff, Daniel (Author) , Hamann, Andreas (Author) , Roser, Pia (Author) , Bierhaus, Angelika (Author) , Nawroth, Peter Paul (Author) , Rudofsky, Gottfried (Author) ,


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