Towards clinical implementation of ultrafast combined kV-MV CBCT for IGRT of lung cancer: evaluation of registration accuracy based on phantom study
Purpose: Combined kV-MV cone-beam CT (CBCT) is a promising approach to accelerate imaging for patients with lung tumors treated with deep inspiration breath-hold. During a single breath-hold (15 s), a 3D kV-MV CBCT can be acquired, thus minimizing motion artifacts and increasing patient comfort. Pri...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
10 February 2016
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| In: |
Strahlentherapie und Onkologie
Year: 2016, Jahrgang: 192, Heft: 5, Pages: 312-321 |
| ISSN: | 1439-099X |
| DOI: | 10.1007/s00066-016-0947-2 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1007/s00066-016-0947-2 |
| Verfasserangaben: | Anna Arns, Manuel Blessing, Jens Fleckenstein, Dzmitry Stsepankou, Judit Boda-Heggemann, Anna Simeonova-Chergou, Jürgen Hesser, Frank Lohr, Frederik Wenz, Hansjörg Wertz |
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| 245 | 1 | 0 | |a Towards clinical implementation of ultrafast combined kV-MV CBCT for IGRT of lung cancer |b evaluation of registration accuracy based on phantom study |c Anna Arns, Manuel Blessing, Jens Fleckenstein, Dzmitry Stsepankou, Judit Boda-Heggemann, Anna Simeonova-Chergou, Jürgen Hesser, Frank Lohr, Frederik Wenz, Hansjörg Wertz |
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| 520 | |a Purpose: Combined kV-MV cone-beam CT (CBCT) is a promising approach to accelerate imaging for patients with lung tumors treated with deep inspiration breath-hold. During a single breath-hold (15 s), a 3D kV-MV CBCT can be acquired, thus minimizing motion artifacts and increasing patient comfort. Prior to clinical implementation, positioning accuracy was evaluated and compared to clinically established imaging techniques. Methods and materials: An inhomogeneous thorax phantom with four tumor-mimicking inlays was imaged in 10 predefined positions and registered to a planning CT. Novel kV-MV CBCT imaging (90° arc) was compared to clinically established kV-chest CBCT (360°) as well as nonclinical kV-CBCT and low-dose MV-CBCT (each 180°). Manual registration, automatic registration provided by the manufacturer and an additional in-house developed manufacturer-independent framework based on the MATLAB registration toolkit were applied. Results: Systematic setup error was reduced to 0.05 mm by high-precision phantom positioning with optical tracking. Stochastic mean displacement errors were 0.5 ± 0.3 mm in right-left, 0.4 ± 0.4 mm in anteroposterior and 0.0 ± 0.4 mm in craniocaudal directions for kV-MV CBCT with manual registration (maximum errors of no more than 1.4 mm). Clinical kV-chest CBCT resulted in mean errors of 0.2 mm (other modalities: 0.4-0.8 mm). Similar results were achieved with both automatic registration methods. Conclusion: The comparison study of repositioning accuracy between novel kV-MV CBCT and clinically established volume imaging demonstrated that registration accuracy is maintained below 1 mm. Since imaging time is reduced to one breath-hold, kV-MV CBCT is ideal for image guidance, e.g., in lung stereotactic ablative radiotherapy. | ||
| 650 | 4 | |a Bildgestützte Radiotherapie | |
| 650 | 4 | |a Cone-beam computed tomography | |
| 650 | 4 | |a Cone-Beam-Computertomographie | |
| 650 | 4 | |a Image-guided radiotherapy | |
| 650 | 4 | |a kV-MV imaging | |
| 650 | 4 | |a kV-MV-Bildgebung | |
| 650 | 4 | |a Lung neoplasms | |
| 650 | 4 | |a Lungenneoplasien | |
| 650 | 4 | |a Patient positioning | |
| 650 | 4 | |a Patientenpositionierung | |
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