Cover Image

Circulating suPAR in two cohorts of primary FSGS

Overexpression of soluble urokinase receptor (suPAR) causes pathology in animal models similar to primary FSGS, and one recent study demonstrated elevated levels of serum suPAR in patients with the disease. Here, we analyzed circulating suPAR levels in two cohorts of children and adults with biopsy-...

Full description

Saved in:
Bibliographic Details
Main Authors: Wei, Changli (Author) , Heil, Karsten M. (Author) , Trautmann, Agnes (Author) , Schaefer, Franz (Author)
Format: Article (Journal)
Language:English
Published: 2012
In: Journal of the American Society of Nephrology
Year: 2012, Volume: 23, Issue: 12, Pages: 2051-2059
ISSN:1533-3450
DOI:10.1681/ASN.2012030302
Online Access:Verlag, Volltext: https://doi.org/10.1681/ASN.2012030302
Verlag, Volltext: https://jasn.asnjournals.org/content/23/12/2051
Get full text
Author Notes:Changli Wei, Howard Trachtman, Jing Li, Chuanhui Dong, Aaron L. Friedman, Jennifer J. Gassman, June L. McMahan, Milena Radeva, Karsten M. Heil, Agnes Trautmann, Ali Anarat, Sevinc Emre, Gian M. Ghiggeri, Fatih Ozaltin, Dieter Haffner, Debbie S. Gipson, Frederick Kaskel, Dagmar-Christiane Fischer, Franz Schaefer, Jochen Reiser, for the PodoNet and FSGS CT Study Consortia

MARC

LEADER 00000caa a2200000 c 4500
001 1663760705
003 DE-627
005 20220816142821.0
007 cr uuu---uuuuu
008 190430s2012 xx |||||o 00| ||eng c
024 7 |a 10.1681/ASN.2012030302  |2 doi 
035 |a (DE-627)1663760705 
035 |a (DE-599)KXP1663760705 
035 |a (OCoLC)1341211914 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Wei, Changli  |e VerfasserIn  |0 (DE-588)118137281X  |0 (DE-627)1662662904  |4 aut 
245 1 0 |a Circulating suPAR in two cohorts of primary FSGS  |c Changli Wei, Howard Trachtman, Jing Li, Chuanhui Dong, Aaron L. Friedman, Jennifer J. Gassman, June L. McMahan, Milena Radeva, Karsten M. Heil, Agnes Trautmann, Ali Anarat, Sevinc Emre, Gian M. Ghiggeri, Fatih Ozaltin, Dieter Haffner, Debbie S. Gipson, Frederick Kaskel, Dagmar-Christiane Fischer, Franz Schaefer, Jochen Reiser, for the PodoNet and FSGS CT Study Consortia 
264 1 |c 2012 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 30.04.2019 
520 |a Overexpression of soluble urokinase receptor (suPAR) causes pathology in animal models similar to primary FSGS, and one recent study demonstrated elevated levels of serum suPAR in patients with the disease. Here, we analyzed circulating suPAR levels in two cohorts of children and adults with biopsy-proven primary FSGS: 70 patients from the North America-based FSGS clinical trial (CT) and 94 patients from PodoNet, the Europe-based consortium studying steroid-resistant nephrotic syndrome. Circulating suPAR levels were elevated in 84.3% and 55.3% of patients with FSGS patients in the CT and PodoNet cohorts, respectively, compared with 6% of controls (P<0.0001); inflammation did not account for this difference. Multiple regression analysis suggested that lower suPAR levels associated with higher estimated GFR, male sex, and treatment with mycophenolate mofetil. In the CT cohort, there was a positive association between the relative reduction of suPAR after 26 weeks of treatment and reduction of proteinuria, with higher odds for complete remission (P=0.04). In the PodoNet cohort, patients with an NPHS2 mutation had higher suPAR levels than those without a mutation. In conclusion, suPAR levels are elevated in geographically and ethnically diverse patients with FSGS and do not reflect a nonspecific proinflammatory milieu. The associations between a change in circulating suPAR with different therapeutic regimens and with remission support the role of suPAR in the pathogenesis of FSGS. 
700 1 |a Heil, Karsten M.  |e VerfasserIn  |0 (DE-588)1184827532  |0 (DE-627)1663723931  |4 aut 
700 1 |a Trautmann, Agnes  |d 1979-  |e VerfasserIn  |0 (DE-588)137067747  |0 (DE-627)589475959  |0 (DE-576)301532834  |4 aut 
700 1 |a Schaefer, Franz  |d 1961-  |e VerfasserIn  |0 (DE-588)1023365383  |0 (DE-627)718365577  |0 (DE-576)366705598  |4 aut 
773 0 8 |i Enthalten in  |a American Society of Nephrology  |t Journal of the American Society of Nephrology  |d Washington, DC : American Society of Nephrology, 1990  |g 23(2012), 12, Seite 2051-2059  |h Online-Ressource  |w (DE-627)324616481  |w (DE-600)2029124-3  |w (DE-576)094113769  |x 1533-3450  |7 nnas 
773 1 8 |g volume:23  |g year:2012  |g number:12  |g pages:2051-2059  |g extent:9  |a Circulating suPAR in two cohorts of primary FSGS 
856 4 0 |u https://doi.org/10.1681/ASN.2012030302  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://jasn.asnjournals.org/content/23/12/2051  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190430 
993 |a Article 
994 |a 2012 
998 |g 1023365383  |a Schaefer, Franz  |m 1023365383:Schaefer, Franz  |d 910000  |d 910500  |e 910000PS1023365383  |e 910500PS1023365383  |k 0/910000/  |k 1/910000/910500/  |p 19 
998 |g 137067747  |a Trautmann, Agnes  |m 137067747:Trautmann, Agnes  |d 910000  |d 910500  |e 910000PT137067747  |e 910500PT137067747  |k 0/910000/  |k 1/910000/910500/  |p 10 
998 |g 1184827532  |a Heil, Karsten M.  |m 1184827532:Heil, Karsten M.  |d 910000  |d 910500  |e 910000PH1184827532  |e 910500PH1184827532  |k 0/910000/  |k 1/910000/910500/  |p 9 
999 |a KXP-PPN1663760705  |e 3456323727 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"2012"}],"relHost":[{"origin":[{"publisher":"American Society of Nephrology ; Ovid","publisherPlace":"Washington, DC ; [Erscheinungsort nicht ermittelbar]","dateIssuedKey":"1990","dateIssuedDisp":"1990-"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"23","issue":"12","text":"23(2012), 12, Seite 2051-2059","pages":"2051-2059","year":"2012","extent":"9"},"id":{"zdb":["2029124-3"],"eki":["324616481"],"issn":["1533-3450"]},"title":[{"subtitle":"JASN","title":"Journal of the American Society of Nephrology","title_sort":"Journal of the American Society of Nephrology"}],"note":["Gesehen am 19.08.24"],"disp":"American Society of NephrologyJournal of the American Society of Nephrology","recId":"324616481","titleAlt":[{"title":"JASN"}],"pubHistory":["1.1990 -"],"corporate":[{"display":"American Society of Nephrology","role":"aut","roleDisplay":"VerfasserIn"}]}],"person":[{"family":"Wei","roleDisplay":"VerfasserIn","role":"aut","display":"Wei, Changli","given":"Changli"},{"family":"Heil","roleDisplay":"VerfasserIn","given":"Karsten M.","display":"Heil, Karsten M.","role":"aut"},{"given":"Agnes","display":"Trautmann, Agnes","role":"aut","roleDisplay":"VerfasserIn","family":"Trautmann"},{"given":"Franz","role":"aut","display":"Schaefer, Franz","roleDisplay":"VerfasserIn","family":"Schaefer"}],"name":{"displayForm":["Changli Wei, Howard Trachtman, Jing Li, Chuanhui Dong, Aaron L. Friedman, Jennifer J. Gassman, June L. McMahan, Milena Radeva, Karsten M. Heil, Agnes Trautmann, Ali Anarat, Sevinc Emre, Gian M. Ghiggeri, Fatih Ozaltin, Dieter Haffner, Debbie S. Gipson, Frederick Kaskel, Dagmar-Christiane Fischer, Franz Schaefer, Jochen Reiser, for the PodoNet and FSGS CT Study Consortia"]},"physDesc":[{"extent":"9 S."}],"note":["Gesehen am 30.04.2019"],"id":{"eki":["1663760705"],"doi":["10.1681/ASN.2012030302"]},"title":[{"title":"Circulating suPAR in two cohorts of primary FSGS","title_sort":"Circulating suPAR in two cohorts of primary FSGS"}],"recId":"1663760705"} 
SRT |a WEICHANGLICIRCULATIN2012 

Similar Items