Results of a combination treatment with intensity modulated radiotherapy and active raster-scanning carbon ion boost for adenoid cystic carcinoma of the minor salivary glands of the nasopharynx
Objectives - We aimed to present the first clinical results for adenoid cystic carcinoma (ACC) of the nasopharynx after primary radiotherapy (RT) with the focus on local control (LC) and patterns of recurrence. - Materials and methods - We retrospectively analyzed 59 patients with ACC of the nasopha...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[April 2019]
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| In: |
Oral oncology
Year: 2019, Jahrgang: 91, Pages: 39-46 |
| ISSN: | 1879-0593 |
| DOI: | 10.1016/j.oraloncology.2019.02.019 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1016/j.oraloncology.2019.02.019 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S1368837519300648 
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| Verfasserangaben: | Sati Akbaba, Dina Ahmed, Kristin Lang, Thomas Held, Matthias Mattke, Juliane Hoerner-Rieber, Klaus Herfarth, Stefan Rieken, Peter Plinkert, Juergen Debus, Sebastian Adeberg |
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| 245 | 1 | 0 | |a Results of a combination treatment with intensity modulated radiotherapy and active raster-scanning carbon ion boost for adenoid cystic carcinoma of the minor salivary glands of the nasopharynx |c Sati Akbaba, Dina Ahmed, Kristin Lang, Thomas Held, Matthias Mattke, Juliane Hoerner-Rieber, Klaus Herfarth, Stefan Rieken, Peter Plinkert, Juergen Debus, Sebastian Adeberg |
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| 520 | |a Objectives - We aimed to present the first clinical results for adenoid cystic carcinoma (ACC) of the nasopharynx after primary radiotherapy (RT) with the focus on local control (LC) and patterns of recurrence. - Materials and methods - We retrospectively analyzed 59 patients with ACC of the nasopharynx, who were treated with bimodal radiotherapy (RT) consisting of intensity modulated radiotherapy and carbon ion boost at the Heidelberg Ion-Beam Therapy Center between 2009 and 2018. The patients had predominantly inoperable (n=42, 72%) or incompletely resected (n=17, 29%) tumors. Kaplan-Meier estimates and the log-rank (Mantel-Cox) test were used for univariate and multivariate analyses. - Results - The median follow-up was 32months. At last follow-up, 67% of the patients were still alive (n=39/58), of whom 74% were free of progression (n=29/39). The 2-year LC, distant progression-free survival (DPFS) and overall survival (OS) were 83%, 81%, 87% and the estimated 5-year LC, DPFS and OS were 49%, 54%, 69%, respectively. LC was significantly inferior in patients with large tumor volumes (gross tumor volume, GTV>100cc, p=0.020) and T4 tumors (p=0.021). The majority of the recurrences occurred at the margin, where critical structures were spared (n=11/19, 58%). Overall, grade 3 toxicity was moderate with 12% acute and 8% late side effects. - Conclusion - Bimodal RT including active raster-scanning carbon ion boost for nasopharyngeal ACC resulted in adequate LC and OS rates with moderate toxicity. T4 stage, large tumor volume and the necessary dose sparing in critical structures, i.e. optic nerves, brain stem and orbit, negatively affected LC. | ||
| 650 | 4 | |a Adenoid cystic carcinoma | |
| 650 | 4 | |a Carbon ion radiotherapy | |
| 650 | 4 | |a Head and neck cancer | |
| 650 | 4 | |a Local control | |
| 650 | 4 | |a Nasopharyngeal tumor | |
| 650 | 4 | |a Recurrence patterns | |
| 650 | 4 | |a Survival outcome | |
| 650 | 4 | |a Toxicity | |
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