Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium
Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loc...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
13 May 2016
|
| In: |
Scientific reports
Year: 2016, Jahrgang: 6 |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/srep25853 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1038/srep25853 Verlag, Volltext: https://www.nature.com/articles/srep25853 
|
| Verfasserangaben: | Qiao Fan, Xiaobo Guo, J. Willem L. Tideman, Katie M. Williams, Seyhan Yazar, S. Mohsen Hosseini, Laura D. Howe, Beaté St Pourcain, David M. Evans, Nicholas J. Timpson, George McMahon, Pirro G. Hysi, Eva Krapohl, Ya Xing Wang, Jost B. Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L. Young, Olavi Pärssinen, Konrad Oexle, Norbert Pfeiffer, Joan E. Bailey-Wilson, Andrew D. Paterson, Caroline C.W. Klaver, Robert Plomin, Christopher J. Hammond, David A. Mackey, Mingguang He, Seang-Mei Saw, Cathy Williams, Jeremy A. Guggenheim and The CREAM Consortium |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1664576657 | ||
| 003 | DE-627 | ||
| 005 | 20220816144001.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190503s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/srep25853 |2 doi | |
| 035 | |a (DE-627)1664576657 | ||
| 035 | |a (DE-599)KXP1664576657 | ||
| 035 | |a (OCoLC)1341212210 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Fan, Qiao |e VerfasserIn |0 (DE-588)118522095X |0 (DE-627)1664576096 |4 aut | |
| 245 | 1 | 0 | |a Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia |b The CREAM Consortium |c Qiao Fan, Xiaobo Guo, J. Willem L. Tideman, Katie M. Williams, Seyhan Yazar, S. Mohsen Hosseini, Laura D. Howe, Beaté St Pourcain, David M. Evans, Nicholas J. Timpson, George McMahon, Pirro G. Hysi, Eva Krapohl, Ya Xing Wang, Jost B. Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L. Young, Olavi Pärssinen, Konrad Oexle, Norbert Pfeiffer, Joan E. Bailey-Wilson, Andrew D. Paterson, Caroline C.W. Klaver, Robert Plomin, Christopher J. Hammond, David A. Mackey, Mingguang He, Seang-Mei Saw, Cathy Williams, Jeremy A. Guggenheim and The CREAM Consortium |
| 264 | 1 | |c 13 May 2016 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 03.05.2019 | ||
| 520 | |a Myopia, currently at epidemic levels in East Asia, is a leading cause of untreatable visual impairment. Genome-wide association studies (GWAS) in adults have identified 39 loci associated with refractive error and myopia. Here, the age-of-onset of association between genetic variants at these 39 loci and refractive error was investigated in 5200 children assessed longitudinally across ages 7-15 years, along with gene-environment interactions involving the major environmental risk-factors, nearwork and time outdoors. Specific variants could be categorized as showing evidence of: (a) early-onset effects remaining stable through childhood, (b) early-onset effects that progressed further with increasing age, or (c) onset later in childhood (N = 10, 5 and 11 variants, respectively). A genetic risk score (GRS) for all 39 variants explained 0.6% (P = 6.6E-08) and 2.3% (P = 6.9E-21) of the variance in refractive error at ages 7 and 15, respectively, supporting increased effects from these genetic variants at older ages. Replication in multi-ancestry samples (combined N = 5599) yielded evidence of childhood onset for 6 of 12 variants present in both Asians and Europeans. There was no indication that variant or GRS effects altered depending on time outdoors, however 5 variants showed nominal evidence of interactions with nearwork (top variant, rs7829127 in ZMAT4; P = 6.3E-04). | ||
| 700 | 1 | |a Jonas, Jost B. |d 1958- |e VerfasserIn |0 (DE-588)1028286732 |0 (DE-627)730536823 |0 (DE-576)37578537X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Scientific reports |d [London] : Springer Nature, 2011 |g 6(2016) Artikel-Nummer 25853, 14 Seiten |h Online-Ressource |w (DE-627)663366712 |w (DE-600)2615211-3 |w (DE-576)346641179 |x 2045-2322 |7 nnas |a Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia The CREAM Consortium |
| 773 | 1 | 8 | |g volume:6 |g year:2016 |g extent:14 |a Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia The CREAM Consortium |
| 856 | 4 | 0 | |u https://doi.org/10.1038/srep25853 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/srep25853 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190503 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 1028286732 |a Jonas, Jost B. |m 1028286732:Jonas, Jost B. |d 60000 |e 60000PJ1028286732 |k 0/60000/ |p 15 | ||
| 999 | |a KXP-PPN1664576657 |e 3461671355 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Fan, Qiao","family":"Fan","role":"aut","given":"Qiao"},{"given":"Jost B.","role":"aut","family":"Jonas","display":"Jonas, Jost B."}],"language":["eng"],"origin":[{"dateIssuedDisp":"13 May 2016","dateIssuedKey":"2016"}],"note":["Gesehen am 03.05.2019"],"title":[{"title_sort":"Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia","subtitle":"The CREAM Consortium","title":"Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"name":{"displayForm":["Qiao Fan, Xiaobo Guo, J. Willem L. Tideman, Katie M. Williams, Seyhan Yazar, S. Mohsen Hosseini, Laura D. Howe, Beaté St Pourcain, David M. Evans, Nicholas J. Timpson, George McMahon, Pirro G. Hysi, Eva Krapohl, Ya Xing Wang, Jost B. Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong, Xiaohu Ding, Robert Wojciechowski, Terri L. Young, Olavi Pärssinen, Konrad Oexle, Norbert Pfeiffer, Joan E. Bailey-Wilson, Andrew D. Paterson, Caroline C.W. Klaver, Robert Plomin, Christopher J. Hammond, David A. Mackey, Mingguang He, Seang-Mei Saw, Cathy Williams, Jeremy A. Guggenheim and The CREAM Consortium"]},"physDesc":[{"extent":"14 S."}],"recId":"1664576657","relHost":[{"language":["eng"],"part":{"volume":"6","extent":"14","text":"6(2016) Artikel-Nummer 25853, 14 Seiten","year":"2016"},"title":[{"title_sort":"Scientific reports","title":"Scientific reports"}],"pubHistory":["1, article number 1 (2011)-"],"origin":[{"publisherPlace":"[London] ; London","publisher":"Springer Nature ; Nature Publishing Group","dateIssuedKey":"2011","dateIssuedDisp":"2011-"}],"note":["Gesehen am 12.07.24"],"disp":"Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia The CREAM ConsortiumScientific reports","type":{"bibl":"periodical","media":"Online-Ressource"},"physDesc":[{"extent":"Online-Ressource"}],"recId":"663366712","id":{"zdb":["2615211-3"],"issn":["2045-2322"],"eki":["663366712"]}}],"id":{"doi":["10.1038/srep25853"],"eki":["1664576657"]}} | ||
| SRT | |a FANQIAOJONCHILDHOODG1320 | ||