HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment
Childhood maltreatment (CM) is a strong risk factor for alcohol dependence (AD) and is associated with a more severe course of the disease. Alterations of the hypothalamic-pituitary-adrenal (HPA) axis may play an important role in this relationship. The aim of the present study was to systematically...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Addiction biology
Year: 2020, Jahrgang: 25, Pages: 1-8 |
| ISSN: | 1369-1600 |
| DOI: | 10.1111/adb.12681 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/adb.12681 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12681 
|
| Verfasserangaben: | Markus Muehlhan, Anja Höcker, Robert Miller, Sebastian Trautmann, Klaus Wiedemann, Annett Lotzin, Sven Barnow, Ingo Schäfer |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1664588337 | ||
| 003 | DE-627 | ||
| 005 | 20230427135430.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190503s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/adb.12681 |2 doi | |
| 035 | |a (DE-627)1664588337 | ||
| 035 | |a (DE-599)KXP1664588337 | ||
| 035 | |a (OCoLC)1341212310 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 11 |2 sdnb | ||
| 100 | 1 | |a Mühlhan, Markus |d 1977- |e VerfasserIn |0 (DE-588)1025489497 |0 (DE-627)722394543 |0 (DE-576)370399331 |4 aut | |
| 245 | 1 | 0 | |a HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment |c Markus Muehlhan, Anja Höcker, Robert Miller, Sebastian Trautmann, Klaus Wiedemann, Annett Lotzin, Sven Barnow, Ingo Schäfer |
| 264 | 1 | |c 2020 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.10.2020 | ||
| 500 | |a First published: 11 October 2018 | ||
| 520 | |a Childhood maltreatment (CM) is a strong risk factor for alcohol dependence (AD) and is associated with a more severe course of the disease. Alterations of the hypothalamic-pituitary-adrenal (HPA) axis may play an important role in this relationship. The aim of the present study was to systematically investigate potential alterations in HPA functioning associated with AD diagnosis and CM. Four study groups were recruited: AD patients with (n = 29; 10♀) and without (n = 33; 8♀) CM and healthy controls with (n = 30; 20♀) and without (n = 38; 15♀) CM. Cumulative cortisol secretion was measured by hair cortisol concentration (HCC). To measure HPA axis response to the Trier social stress test (TSST), saliva and blood samples were analysed for adrenocorticotropic hormone (ACTH) and cortisol. In the AD groups, the period of hair growth covered acute alcohol consumption and withdrawal. The TSST was scheduled after completion of withdrawal. Irrespective of CM, higher HCCs and reduced ACTH and cortisol levels before and after TSST were observed in AD patients. The analyses did not reveal any differences between AD patients with and without CM. Healthy controls with CM had lower plasma cortisol levels compared with those without CM. The results suggest that AD is strongly related to HPA axis functioning, which may superimpose possible differences between AD patients with and without CM. Future studies should investigate whether biologically different subtypes of AD with and without CM can be identified in earlier stages or before the development of AD. | ||
| 650 | 4 | |a ACTH | |
| 650 | 4 | |a alcohol dependence | |
| 650 | 4 | |a childhood maltreatment | |
| 650 | 4 | |a cortisol | |
| 650 | 4 | |a HPA axis | |
| 650 | 4 | |a stress | |
| 700 | 1 | |a Höcker, Anja |e VerfasserIn |0 (DE-588)1028653492 |0 (DE-627)731474090 |0 (DE-576)376176601 |4 aut | |
| 700 | 1 | |a Miller, Robert |d 1984- |e VerfasserIn |0 (DE-588)1037416481 |0 (DE-627)755685571 |0 (DE-576)391435892 |4 aut | |
| 700 | 1 | |a Trautmann, Sebastian |d 1983- |e VerfasserIn |0 (DE-588)1193659671 |0 (DE-627)1672396840 |4 aut | |
| 700 | 1 | |a Wiedemann, Klaus |d 1955- |e VerfasserIn |0 (DE-588)1133041663 |0 (DE-627)888187920 |0 (DE-576)489072755 |4 aut | |
| 700 | 1 | |a Lotzin, Annett |e VerfasserIn |0 (DE-588)1028641370 |0 (DE-627)731440439 |0 (DE-576)376154322 |4 aut | |
| 700 | 1 | |a Barnow, Sven |d 1964- |e VerfasserIn |0 (DE-588)121771180 |0 (DE-627)081523548 |0 (DE-576)182144836 |4 aut | |
| 700 | 1 | |a Schäfer, Ingo |d 1971- |e VerfasserIn |0 (DE-588)129262447 |0 (DE-627)391868802 |0 (DE-576)297567705 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Addiction biology |d Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 |g 25(2020), Artikel-ID e12681, Seite 1-8 |h Online-Ressource |w (DE-627)303614633 |w (DE-600)1495537-4 |w (DE-576)097694592 |x 1369-1600 |7 nnas |a HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment |
| 773 | 1 | 8 | |g volume:25 |g year:2020 |g elocationid:e12681 |g pages:1-8 |g extent:8 |a HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment |
| 856 | 4 | 0 | |u https://doi.org/10.1111/adb.12681 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/adb.12681 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190503 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 121771180 |a Barnow, Sven |m 121771180:Barnow, Sven |d 100000 |d 100200 |e 100000PB121771180 |e 100200PB121771180 |k 0/100000/ |k 1/100000/100200/ |p 7 | ||
| 999 | |a KXP-PPN1664588337 |e 3461692840 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"year":"2020","extent":"8","pages":"1-8","text":"25(2020), Artikel-ID e12681, Seite 1-8","volume":"25"},"origin":[{"dateIssuedDisp":"1996-","dateIssuedKey":"1996","publisherPlace":"Hoboken, NJ [u.a.] ; Abingdon ; [Erscheinungsort nicht ermittelbar]","publisher":"Wiley-Blackwell ; Carfax Publ. Co. ; Blackwell"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"id":{"issn":["1369-1600"],"zdb":["1495537-4"],"eki":["303614633"],"doi":["10.1111/(ISSN)1369-1600"]},"title":[{"title":"Addiction biology","title_sort":"Addiction biology"}],"disp":"HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatmentAddiction biology","note":["Gesehen am 14.05.24"],"pubHistory":["1.1996 -"],"recId":"303614633"}],"physDesc":[{"extent":"8 S."}],"person":[{"display":"Mühlhan, Markus","role":"aut","given":"Markus","family":"Mühlhan","roleDisplay":"VerfasserIn"},{"family":"Höcker","roleDisplay":"VerfasserIn","display":"Höcker, Anja","role":"aut","given":"Anja"},{"given":"Robert","role":"aut","display":"Miller, Robert","roleDisplay":"VerfasserIn","family":"Miller"},{"roleDisplay":"VerfasserIn","family":"Trautmann","given":"Sebastian","role":"aut","display":"Trautmann, Sebastian"},{"role":"aut","display":"Wiedemann, Klaus","given":"Klaus","family":"Wiedemann","roleDisplay":"VerfasserIn"},{"given":"Annett","role":"aut","display":"Lotzin, Annett","roleDisplay":"VerfasserIn","family":"Lotzin"},{"family":"Barnow","roleDisplay":"VerfasserIn","given":"Sven","role":"aut","display":"Barnow, Sven"},{"given":"Ingo","display":"Schäfer, Ingo","role":"aut","roleDisplay":"VerfasserIn","family":"Schäfer"}],"name":{"displayForm":["Markus Muehlhan, Anja Höcker, Robert Miller, Sebastian Trautmann, Klaus Wiedemann, Annett Lotzin, Sven Barnow, Ingo Schäfer"]},"language":["eng"],"origin":[{"dateIssuedDisp":"2020","dateIssuedKey":"2020"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 05.10.2020","First published: 11 October 2018"],"id":{"doi":["10.1111/adb.12681"],"eki":["1664588337"]},"title":[{"title_sort":"HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment","title":"HPA axis stress reactivity and hair cortisol concentrations in recently detoxified alcoholics and healthy controls with and without childhood maltreatment"}],"recId":"1664588337"} | ||
| SRT | |a MUEHLHANMAHPAAXISSTR2020 | ||