Cover Image

Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans

We investigated the effects of a non-specific sodium channel blocker (lidocaine) on heat pain thresholds and mechanical impact pain at day 7 and 21 after intradermal injection of 1 μg NGF. Measurements were performed in 12 healthy male subjects prior to and 5 min after intradermal injection of 150 μ...

Full description

Saved in:
Bibliographic Details
Main Authors: Weinkauf, Benjamin (Author) , Obreja, Otilia (Author) , Schmelz, Martin (Author) , Rukwied, Roman (Author)
Format: Article (Journal)
Language:English
Published: 06 March 2012
In: European journal of pain
Year: 2012, Volume: 16, Issue: 4, Pages: 543-549
ISSN:1532-2149
DOI:10.1016/j.ejpain.2011.08.004
Online Access:Verlag, Volltext: https://doi.org/10.1016/j.ejpain.2011.08.004
Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1016/j.ejpain.2011.08.004
Get full text
Author Notes:B. Weinkauf, O. Obreja, M. Schmelz, R. Rukwied

MARC

LEADER 00000caa a2200000 c 4500
001 1664848800
003 DE-627
005 20220816144655.0
007 cr uuu---uuuuu
008 190507s2012 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.ejpain.2011.08.004  |2 doi 
035 |a (DE-627)1664848800 
035 |a (DE-599)KXP1664848800 
035 |a (OCoLC)1341212216 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Weinkauf, Benjamin  |d 1983-  |e VerfasserIn  |0 (DE-588)102779159X  |0 (DE-627)729738191  |0 (DE-576)375320520  |4 aut 
245 1 0 |a Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans  |c B. Weinkauf, O. Obreja, M. Schmelz, R. Rukwied 
264 1 |c 06 March 2012 
300 |a 7 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 07.05.2019 
520 |a We investigated the effects of a non-specific sodium channel blocker (lidocaine) on heat pain thresholds and mechanical impact pain at day 7 and 21 after intradermal injection of 1 μg NGF. Measurements were performed in 12 healthy male subjects prior to and 5 min after intradermal injection of 150 μl lidocaine administered at concentrations of 0.01% (∼0.4 mM) and 0.1% (∼4 mM) to both NGF and control skin sites. NGF caused a maximum reduction of heat pain thresholds at day 7 (NGF 42.6 ± 0.6 vs. 49.4 ± 0.3 °C in control skin). Lidocaine sensitized normal skin for heat pain, but reduced heat hyperalgesia after NGF at day 7 (44.3 ± 0.8 °C, lidocaine 0.1%; p < 0.005). Pain upon supra-threshold mechanical impact stimulation was increased after NGF at day 7 (VAS 29 + 5) and massively enhanced at day 21 (VAS 64 + 5, p < 0.001). Lidocaine dose-dependently attenuated mechanically-induced pain at both control and NGF-treated sites. Maximum lidocaine effects on mechanical hyperalgesia were recorded at day 21 in NGF skin (pain reduction to VAS 37 ± 4, p < 0.00001). Repetitive impact stimuli caused increasingly more pain at the NGF sites at day 21 and this pain increase was efficiently suppressed by lidocaine 0.1%. Lidocaine differentially affects NGF-induced mechanical hyperalgesia (analgesic effect) and heat sensitivity of nociceptors (sensitizing effect). These opposing responses may be attributed to block of sodium channels vs. sensitization of TRPV1. NGF-evoked extreme mechanical impact pain indicates high action potential discharge frequencies, which might be more susceptible to lidocaine block. 
700 1 |a Obreja, Otilia  |d 1970-  |e VerfasserIn  |0 (DE-588)12455797X  |0 (DE-627)363420126  |0 (DE-576)294231005  |4 aut 
700 1 |a Schmelz, Martin  |d 1962-  |e VerfasserIn  |0 (DE-588)115466517  |0 (DE-627)691338027  |0 (DE-576)289899427  |4 aut 
700 1 |a Rukwied, Roman  |d 1963-  |e VerfasserIn  |0 (DE-588)121127486  |0 (DE-627)08110524X  |0 (DE-576)29255026X  |4 aut 
773 0 8 |i Enthalten in  |t European journal of pain  |d Malden, Mass. [u.a.] : Wiley-Blackwell, 1997  |g 16(2012), 4, Seite 543-549  |h Online-Ressource  |w (DE-627)320420485  |w (DE-600)2002493-9  |w (DE-576)267761791  |x 1532-2149  |7 nnas  |a Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans 
773 1 8 |g volume:16  |g year:2012  |g number:4  |g pages:543-549  |g extent:7  |a Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans 
856 4 0 |u https://doi.org/10.1016/j.ejpain.2011.08.004  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://onlinelibrary.wiley.com/doi/abs/10.1016/j.ejpain.2011.08.004  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190507 
993 |a Article 
994 |a 2012 
998 |g 121127486  |a Rukwied, Roman  |m 121127486:Rukwied, Roman  |d 60000  |d 61600  |e 60000PR121127486  |e 61600PR121127486  |k 0/60000/  |k 1/60000/61600/  |p 4  |y j 
998 |g 115466517  |a Schmelz, Martin  |m 115466517:Schmelz, Martin  |d 60000  |d 61600  |e 60000PS115466517  |e 61600PS115466517  |k 0/60000/  |k 1/60000/61600/  |p 3 
998 |g 12455797X  |a Obreja, Otilia  |m 12455797X:Obreja, Otilia  |d 60000  |d 61600  |e 60000PO12455797X  |e 61600PO12455797X  |k 0/60000/  |k 1/60000/61600/  |p 2 
998 |g 102779159X  |a Weinkauf, Benjamin  |m 102779159X:Weinkauf, Benjamin  |d 60000  |d 61600  |e 60000PW102779159X  |e 61600PW102779159X  |k 0/60000/  |k 1/60000/61600/  |p 1  |x j 
999 |a KXP-PPN1664848800  |e 3471860711 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"doi":["10.1016/j.ejpain.2011.08.004"],"eki":["1664848800"]},"recId":"1664848800","name":{"displayForm":["B. Weinkauf, O. Obreja, M. Schmelz, R. Rukwied"]},"relHost":[{"id":{"eki":["320420485"],"issn":["1532-2149"],"zdb":["2002493-9"],"doi":["10.1002/(ISSN)1532-2149"]},"recId":"320420485","language":["eng"],"titleAlt":[{"title":"EJP"}],"disp":"Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humansEuropean journal of pain","physDesc":[{"extent":"Online-Ressource"}],"part":{"volume":"16","pages":"543-549","extent":"7","year":"2012","issue":"4","text":"16(2012), 4, Seite 543-549"},"type":{"media":"Online-Ressource","bibl":"periodical"},"origin":[{"dateIssuedDisp":"1997-","publisherPlace":"Malden, Mass. [u.a.] ; London [u.a.] ; Burlington, Mass. ; New York, NY","publisher":"Wiley-Blackwell ; Saunders ; Harcourt ; Elsevier","dateIssuedKey":"1997"}],"title":[{"title":"European journal of pain","title_sort":"European journal of pain","subtitle":"EJP"}],"pubHistory":["1.1997 -"],"note":["Gesehen am 10.12.2014"]}],"physDesc":[{"extent":"7 S."}],"language":["eng"],"title":[{"title":"Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans","title_sort":"Differential effects of lidocaine on nerve growth factor (NGF)-evoked heat- and mechanical hyperalgesia in humans"}],"person":[{"role":"aut","given":"Benjamin","family":"Weinkauf","display":"Weinkauf, Benjamin"},{"display":"Obreja, Otilia","family":"Obreja","given":"Otilia","role":"aut"},{"role":"aut","given":"Martin","family":"Schmelz","display":"Schmelz, Martin"},{"given":"Roman","family":"Rukwied","display":"Rukwied, Roman","role":"aut"}],"origin":[{"dateIssuedKey":"2012","dateIssuedDisp":"06 March 2012"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Gesehen am 07.05.2019"]} 
SRT |a WEINKAUFBEDIFFERENTI0620 

Similar Items