Impact of centralized evaluation of bone marrow histology in systemic mastocytosis
Background Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). Materials and methods Within the ‘German Registry of Disorders on Eosinophils and Mast Cells’, we identified 65 pat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
23 February 2016
|
| In: |
European journal of clinical investigation
Year: 2016, Volume: 46, Issue: 5, Pages: 392-397 |
| ISSN: | 1365-2362 |
| DOI: | 10.1111/eci.12607 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1111/eci.12607 Verlag, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12607 
|
| Author Notes: | Mohamad Jawhar, Juliana Schwaab, Hans-Peter Horny, Karl Sotlar, Nicole Naumann, Alice Fabarius, Peter Valent, Nicholas C. P. Cross, Wolf-Karsten Hofmann, Georgia Metzgeroth, Andreas Reiter |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1664904417 | ||
| 003 | DE-627 | ||
| 005 | 20230426130900.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190507s2016 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/eci.12607 |2 doi | |
| 035 | |a (DE-627)1664904417 | ||
| 035 | |a (DE-599)KXP1664904417 | ||
| 035 | |a (OCoLC)1341212140 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Jawhar, Mohamad |d 1986- |e VerfasserIn |0 (DE-588)1046172905 |0 (DE-627)775847747 |0 (DE-576)399437061 |4 aut | |
| 245 | 1 | 0 | |a Impact of centralized evaluation of bone marrow histology in systemic mastocytosis |c Mohamad Jawhar, Juliana Schwaab, Hans-Peter Horny, Karl Sotlar, Nicole Naumann, Alice Fabarius, Peter Valent, Nicholas C. P. Cross, Wolf-Karsten Hofmann, Georgia Metzgeroth, Andreas Reiter |
| 264 | 1 | |c 23 February 2016 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.05.2019 | ||
| 520 | |a Background Bone marrow (BM) histology/immunohistochemistry, KIT D816V mutation analysis and serum tryptase measurements are mandatory tools for diagnosis of systemic mastocytosis (SM). Materials and methods Within the ‘German Registry of Disorders on Eosinophils and Mast Cells’, we identified 65 patients with SM who had two consecutive BM biopsies. The first biopsy was evaluated by a local pathologist (LP) and the second biopsy by a reference pathologist (RP) of the ‘European Competence Network on Mastocytosis (ECNM)’. Results Final diagnoses by RP were SM (n = 27), SM or aggressive SM (ASM) with associated clonal haematological non-mast cell lineage disease [(A)SM-AHNMD, n = 34)] or mast cell leukaemia ± AHNMD (n = 4). In 15 of 65 patients (23%), initial diagnoses by LP were incorrect (by overlooking SM), for example primary myelofibrosis (n = 3), myelodysplastic/myeloproliferative neoplasm unclassified (n = 3) or B-cell lymphoma (n = 2). Fourteen of 15 patients (93%) with incorrect diagnosis had an advanced SM, mostly (A)SM-AHNMD. In the 50 concordantly diagnosed patients, immunohistochemical markers for quantitative assessment of mast cell infiltration, for example CD117 (KIT) or CD25, were applied by LP in only 34 of 50 patients (68%), and mutational analysis for KIT D816V was performed or recommended in only 13 of 50 patients (26%). Finally, the subclassification of SM was discordant because LP did not diagnose AHNMD in nine of 50 (18%) patients. Conclusions In summary, adequate diagnosis and subclassification of SM requires an in-depth evaluation of the BM by experienced haematopathologists (preferably in a reference centre) in combination with molecular genetics, serum tryptase level and clinical parameters. | ||
| 650 | 4 | |a Bone marrow histology | |
| 650 | 4 | |a European Competence Network on Mastocytosis | |
| 650 | 4 | |a misdiagnosis | |
| 650 | 4 | |a systemic mastocytosis | |
| 700 | 1 | |a Schwaab, Juliana |d 1982- |e VerfasserIn |0 (DE-588)1051912687 |0 (DE-627)787019399 |0 (DE-576)407558764 |4 aut | |
| 700 | 1 | |a Naumann, Nicole |d 1988- |e VerfasserIn |0 (DE-588)1138951838 |0 (DE-627)896569624 |0 (DE-576)49279314X |4 aut | |
| 700 | 1 | |a Fabarius, Alice |d 1965- |e VerfasserIn |0 (DE-588)1037001281 |0 (DE-627)751728314 |0 (DE-576)390896667 |4 aut | |
| 700 | 1 | |a Hofmann, Wolf-Karsten |d 1967- |e VerfasserIn |0 (DE-588)114154635 |0 (DE-627)691208751 |0 (DE-576)351568336 |4 aut | |
| 700 | 1 | |a Metzgeroth, Georgia |d 1972- |e VerfasserIn |0 (DE-588)1051897661 |0 (DE-627)786986832 |0 (DE-576)407534075 |4 aut | |
| 700 | 1 | |a Reiter, Andreas |d 1964- |e VerfasserIn |0 (DE-588)172629551 |0 (DE-627)697563766 |0 (DE-576)133488594 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of clinical investigation |d Oxford [u.a.] : Wiley-Blackwell, 1970 |g 46(2016), 5, Seite 392-397 |h Online-Ressource |w (DE-627)320441423 |w (DE-600)2004971-7 |w (DE-576)091142695 |x 1365-2362 |7 nnas |a Impact of centralized evaluation of bone marrow histology in systemic mastocytosis |
| 773 | 1 | 8 | |g volume:46 |g year:2016 |g number:5 |g pages:392-397 |g extent:6 |a Impact of centralized evaluation of bone marrow histology in systemic mastocytosis |
| 856 | 4 | 0 | |u https://doi.org/10.1111/eci.12607 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/eci.12607 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190507 | ||
| 993 | |a Article | ||
| 994 | |a 2016 | ||
| 998 | |g 172629551 |a Reiter, Andreas |m 172629551:Reiter, Andreas |d 60000 |d 61200 |e 60000PR172629551 |e 61200PR172629551 |k 0/60000/ |k 1/60000/61200/ |p 11 |y j | ||
| 998 | |g 1051897661 |a Metzgeroth, Georgia |m 1051897661:Metzgeroth, Georgia |d 60000 |d 61200 |e 60000PM1051897661 |e 61200PM1051897661 |k 0/60000/ |k 1/60000/61200/ |p 10 | ||
| 998 | |g 114154635 |a Hofmann, Wolf-Karsten |m 114154635:Hofmann, Wolf-Karsten |d 60000 |d 61200 |e 60000PH114154635 |e 61200PH114154635 |k 0/60000/ |k 1/60000/61200/ |p 9 | ||
| 998 | |g 1037001281 |a Fabarius, Alice |m 1037001281:Fabarius, Alice |d 60000 |d 61200 |e 60000PF1037001281 |e 61200PF1037001281 |k 0/60000/ |k 1/60000/61200/ |p 6 | ||
| 998 | |g 1138951838 |a Naumann, Nicole |m 1138951838:Naumann, Nicole |d 60000 |d 61200 |e 60000PN1138951838 |e 61200PN1138951838 |k 0/60000/ |k 1/60000/61200/ |p 5 | ||
| 998 | |g 1051912687 |a Schwaab, Juliana |m 1051912687:Schwaab, Juliana |d 60000 |d 61200 |e 60000PS1051912687 |e 61200PS1051912687 |k 0/60000/ |k 1/60000/61200/ |p 2 | ||
| 998 | |g 1046172905 |a Jawhar, Mohamad |m 1046172905:Jawhar, Mohamad |d 60000 |d 61200 |e 60000PJ1046172905 |e 61200PJ1046172905 |k 0/60000/ |k 1/60000/61200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1664904417 |e 3472019522 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"physDesc":[{"extent":"6 S."}],"language":["eng"],"recId":"1664904417","id":{"doi":["10.1111/eci.12607"],"eki":["1664904417"]},"name":{"displayForm":["Mohamad Jawhar, Juliana Schwaab, Hans-Peter Horny, Karl Sotlar, Nicole Naumann, Alice Fabarius, Peter Valent, Nicholas C. P. Cross, Wolf-Karsten Hofmann, Georgia Metzgeroth, Andreas Reiter"]},"relHost":[{"origin":[{"dateIssuedDisp":"1970-","publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell","publisherPlace":"Oxford [u.a.] ; Oxford [u.a.] ; Oxford [u.a.]","dateIssuedKey":"1970"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"doi":["10.1111/(ISSN)1365-2362"],"issn":["1365-2362"],"zdb":["2004971-7"],"eki":["320441423"]},"title":[{"subtitle":"the journal of the European Society for Clinical Investigation","title_sort":"European journal of clinical investigation","title":"European journal of clinical investigation"}],"pubHistory":["1.1970/71 -"],"recId":"320441423","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Impact of centralized evaluation of bone marrow histology in systemic mastocytosisEuropean journal of clinical investigation","part":{"extent":"6","volume":"46","pages":"392-397","text":"46(2016), 5, Seite 392-397","year":"2016","issue":"5"}}],"note":["Gesehen am 07.05.2019"],"person":[{"family":"Jawhar","given":"Mohamad","display":"Jawhar, Mohamad","role":"aut"},{"role":"aut","display":"Schwaab, Juliana","family":"Schwaab","given":"Juliana"},{"role":"aut","given":"Nicole","family":"Naumann","display":"Naumann, Nicole"},{"role":"aut","display":"Fabarius, Alice","family":"Fabarius","given":"Alice"},{"given":"Wolf-Karsten","family":"Hofmann","display":"Hofmann, Wolf-Karsten","role":"aut"},{"given":"Georgia","family":"Metzgeroth","display":"Metzgeroth, Georgia","role":"aut"},{"role":"aut","display":"Reiter, Andreas","given":"Andreas","family":"Reiter"}],"title":[{"title_sort":"Impact of centralized evaluation of bone marrow histology in systemic mastocytosis","title":"Impact of centralized evaluation of bone marrow histology in systemic mastocytosis"}],"origin":[{"dateIssuedDisp":"23 February 2016","dateIssuedKey":"2016"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} | ||
| SRT | |a JAWHARMOHAIMPACTOFCE2320 | ||