Chitosan functionalized poly-ε-caprolactone electrospun fibers and 3D printed scaffolds as antibacterial materials for tissue engineering applications
Tissue engineering (TE) approaches often employ polymer-based scaffolds to provide support with a view to the improved regeneration of damaged tissues. The aim of this research was to develop a surface modification method for introducing chitosan as an antibacterial agent in both electrospun membran...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
21 February 2018
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| In: |
Carbohydrate polymers
Year: 2018, Volume: 191, Pages: 127-135 |
| ISSN: | 1879-1344 |
| DOI: | 10.1016/j.carbpol.2018.02.060 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.carbpol.2018.02.060 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0144861718302182 
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| Author Notes: | Myriam G. Tardajos, Giuseppe Cama, Mamoni Dash, Lara Misseeuw, Tom Gheysens, Christian Gorzelanny, Tom Coenye, Peter Dubruel |
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| 520 | |a Tissue engineering (TE) approaches often employ polymer-based scaffolds to provide support with a view to the improved regeneration of damaged tissues. The aim of this research was to develop a surface modification method for introducing chitosan as an antibacterial agent in both electrospun membranes and 3D printed poly-ε-caprolactone (PCL) scaffolds. The scaffolds were functionalized by grafting methacrylic acid N-hydroxysuccinimide ester (NHSMA) onto the surface after Ar-plasma/air activation. Subsequently, the newly-introduced NHS groups were used to couple with chitosan of various molecular weights (Mw). High Mw chitosan exhibited a better coverage of the surface as indicated by the higher N% detected by X-ray photoelectron spectroscopy (XPS) and the observations with either scanning electron microscopy (SEM)(for fibers) or Coomassie blue staining (for 3D-printed scaffolds). A lactate dehydrogenase assay (LDH) using L929 fibroblasts demonstrated the cell-adhesion and cell-viability capacity of the modified samples. The antibacterial properties against S. aureus ATCC 6538 and S. epidermidis ET13 revealed a slower bacterial growth rate on the surface of the chitosan modified scaffolds, regardless the chitosan Mw. | ||
| 650 | 4 | |a Antibacterial | |
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