Pharmacodynamics and pharmacokinetics of lidocaine in a rodent model of diabetic neuropathy
Background:Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic ner
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| Main Authors: | , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2018/03/01
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| In: |
Anesthesiology
Year: 2018, Volume: 128, Issue: 3, Pages: 609-619 |
| ISSN: | 1528-1175 |
| DOI: | 10.1097/ALN.0000000000002035 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1097/ALN.0000000000002035
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| Author Notes: | Werner ten Hoope, Markus Hollmann, Kora de Bruin, Hein Verberne, Arie Verkerk, Hanno Tan, Camiel Verhamme, Janneke Horn, Marcel Rigaud, Susanne Picardi, Philipp Lirk |
MARC
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| 520 | |a Background:Clinical and experimental data show that peripheral nerve blocks last longer in the presence of diabetic neuropathy. This may occur because diabetic nerve fibers are more sensitive to local anesthetics or because the local anesthetic concentration decreases more slowly in the diabetic ner | ||
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