Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons
Axonal excitability is an important determinant for the accuracy, direction, and velocity of neuronal signaling. The mechanisms underlying spike generation in the axonal initial segment and transmitter release from presynaptic terminals have been intensely studied and revealed a role for several spe...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 June 2018
|
| In: |
Journal of neurochemistry
Year: 2018, Volume: 146, Issue: 4, Pages: 446-458 |
| ISSN: | 1471-4159 |
| DOI: | 10.1111/jnc.14479 |
| Online Access: | Verlag, Pay-per-use, Volltext: https://doi.org/10.1111/jnc.14479 Verlag, Pay-per-use, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14479 
|
| Author Notes: | Peter Müller, Andreas Draguhn and Alexei V. Egorov |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1665291966 | ||
| 003 | DE-627 | ||
| 005 | 20220816151243.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190513s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/jnc.14479 |2 doi | |
| 035 | |a (DE-627)1665291966 | ||
| 035 | |a (DE-599)KXP1665291966 | ||
| 035 | |a (OCoLC)1341212832 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 30 |2 sdnb | ||
| 100 | 1 | |a Müller, Peter |d 1994- |e VerfasserIn |0 (DE-588)1186003707 |0 (DE-627)1665292776 |4 aut | |
| 245 | 1 | 0 | |a Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons |c Peter Müller, Andreas Draguhn and Alexei V. Egorov |
| 264 | 1 | |c 04 June 2018 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 13.05.2019 | ||
| 520 | |a Axonal excitability is an important determinant for the accuracy, direction, and velocity of neuronal signaling. The mechanisms underlying spike generation in the axonal initial segment and transmitter release from presynaptic terminals have been intensely studied and revealed a role for several specific ionic conductances, including the persistent sodium current (INaP). Recent evidence indicates that action potentials can also be generated at remote locations along the axonal fiber, giving rise to ectopic action potentials during physiological states (e.g., fast network oscillations) or in pathological situations (e.g., following demyelination). Here, we investigated how ectopic axonal excitability of mouse hippocampal CA1 pyramidal neurons is regulated by INaP. Recordings of field potentials and intracellular voltage in brain slices revealed that electrically evoked antidromic spikes were readily suppressed by two different blockers of INaP, riluzole and phenytoin. The effect was mediated by a reduction of the probability of ectopic spike generation while latency was unaffected. Interestingly, the contribution of INaP to excitability was much more pronounced in axonal branches heading toward the entorhinal cortex compared with the opposite fiber direction toward fimbria. Thus, excitability of distal CA1 pyramidal cell axons is affected by persistent sodium currents in a direction-selective manner. This mechanism may be of importance for ectopic spike generation in oscillating network states as well as in pathological situations. | ||
| 650 | 4 | |a axon | |
| 650 | 4 | |a ectopic action potential | |
| 650 | 4 | |a hippocampal slice | |
| 650 | 4 | |a persistent sodium current | |
| 650 | 4 | |a phenytoin | |
| 650 | 4 | |a riluzole | |
| 700 | 1 | |a Draguhn, Andreas |d 1961- |e VerfasserIn |0 (DE-588)121130282 |0 (DE-627)081107102 |0 (DE-576)292552394 |4 aut | |
| 700 | 1 | |a Egorov, Alexei |d 1971- |e VerfasserIn |0 (DE-588)122316843 |0 (DE-627)705859053 |0 (DE-576)184075238 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of neurochemistry |d Oxford : Wiley-Blackwell, 1956 |g 146(2018), 4, Seite 446-458 |h Online-Ressource |w (DE-627)320604063 |w (DE-600)2020528-4 |w (DE-576)091137454 |x 1471-4159 |7 nnas |a Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons |
| 773 | 1 | 8 | |g volume:146 |g year:2018 |g number:4 |g pages:446-458 |g extent:13 |a Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons |
| 856 | 4 | 0 | |u https://doi.org/10.1111/jnc.14479 |x Verlag |x Resolving-System |z Pay-per-use |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.14479 |x Verlag |z Pay-per-use |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190513 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 122316843 |a Egorov, Alexei |m 122316843:Egorov, Alexei |d 50000 |d 53200 |e 50000PE122316843 |e 53200PE122316843 |k 0/50000/ |k 1/50000/53200/ |p 3 |y j | ||
| 998 | |g 121130282 |a Draguhn, Andreas |m 121130282:Draguhn, Andreas |d 50000 |d 53200 |e 50000PD121130282 |e 53200PD121130282 |k 0/50000/ |k 1/50000/53200/ |p 2 | ||
| 998 | |g 1186003707 |a Müller, Peter |m 1186003707:Müller, Peter |d 50000 |d 53200 |e 50000PM1186003707 |e 53200PM1186003707 |k 0/50000/ |k 1/50000/53200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1665291966 |e 3475503786 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"corporate":[{"role":"isb","display":"International Society for Neurochemistry","roleDisplay":"Herausgebendes Organ"}],"disp":"Persistent sodium current modulates axonal excitability in CA1 pyramidal neuronsJournal of neurochemistry","titleAlt":[{"title":"JNC"}],"part":{"extent":"13","issue":"4","volume":"146","text":"146(2018), 4, Seite 446-458","pages":"446-458","year":"2018"},"pubHistory":["1.1956/57 -"],"language":["eng"],"title":[{"subtitle":"official journal of the International Society for Neurochemistry ; JNC","title":"Journal of neurochemistry","title_sort":"Journal of neurochemistry"}],"note":["Fortsetzung der Druck-Ausgabe","Gesehen am 08.04.22"],"recId":"320604063","physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"1956","publisherPlace":"Oxford ; Stanford, Calif. ; Oxford [u.a.]","dateIssuedDisp":"1956-","publisher":"Wiley-Blackwell ; HighWire Press ; Blackwell"}],"id":{"zdb":["2020528-4"],"issn":["1471-4159"],"doi":["10.1111/(ISSN)1471-4159"],"eki":["320604063"]},"type":{"bibl":"periodical","media":"Online-Ressource"}}],"physDesc":[{"extent":"13 S."}],"name":{"displayForm":["Peter Müller, Andreas Draguhn and Alexei V. Egorov"]},"recId":"1665291966","note":["Gesehen am 13.05.2019"],"person":[{"given":"Peter","display":"Müller, Peter","role":"aut","family":"Müller","roleDisplay":"VerfasserIn"},{"given":"Andreas","role":"aut","display":"Draguhn, Andreas","family":"Draguhn","roleDisplay":"VerfasserIn"},{"given":"Alexei","display":"Egorov, Alexei","role":"aut","family":"Egorov","roleDisplay":"VerfasserIn"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons","title_sort":"Persistent sodium current modulates axonal excitability in CA1 pyramidal neurons"}],"origin":[{"dateIssuedDisp":"04 June 2018","dateIssuedKey":"2018"}],"id":{"doi":["10.1111/jnc.14479"],"eki":["1665291966"]},"language":["eng"]} | ||
| SRT | |a MUELLERPETPERSISTENT0420 | ||