Buchumschlag

A new population of parvocellular oxytocin neurons controlling magnocellular neuron activity and inflammatory pain processing

Summary - Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Eliava, Marina (VerfasserIn) , Silva Gouveia, Miriam da (VerfasserIn) , Althammer, Ferdinand (VerfasserIn) , Chini, Bice (VerfasserIn) , Tan, Linette Liqi (VerfasserIn) , Kuner, Rohini (VerfasserIn) , Grinevich, Valéry (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 March 2016
In: Neuron
Year: 2016, Jahrgang: 89, Heft: 6, Pages: 1291-1304
ISSN:1097-4199
DOI:10.1016/j.neuron.2016.01.041
Online-Zugang:Verlag, Volltext: https://doi.org/10.1016/j.neuron.2016.01.041
Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S089662731600088X
Volltext
Verfasserangaben:Marina Eliava, Meggane Melchior, H. Sophie Knobloch-Bollmann, Jérôme Wahis, Miriam da Silva Gouveia, Yan Tang, Alexandru Cristian Ciobanu, Rodrigo Triana del Rio, Lena C. Roth, Ferdinand Althammer, Virginie Chavant, Yannick Goumon, Tim Gruber, Nathalie Petit-Demoulière, Marta Busnelli, Bice Chini, Linette L. Tan, Mariela Mitre, Robert C. Froemke, Moses V. Chao, Günter Giese, Rolf Sprengel, Rohini Kuner, Pierrick Poisbeau, Peter H. Seeburg, Ron Stoop, Alexandre Charlet, Valery Grinevich
Beschreibung
Zusammenfassung:Summary - Oxytocin (OT) is a neuropeptide elaborated by the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei. Magnocellular OT neurons of these nuclei innervate numerous forebrain regions and release OT into the blood from the posterior pituitary. The PVN also harbors parvocellular OT cells that project to the brainstem and spinal cord, but their function has not been directly assessed. Here, we identified a subset of approximately 30 parvocellular OT neurons, with collateral projections onto magnocellular OT neurons and neurons of deep layers of the spinal cord. Evoked OT release from these OT neurons suppresses nociception and promotes analgesia in an animal model of inflammatory pain. Our findings identify a new population of OT neurons that modulates nociception in a two tier process: (1) directly by release of OT from axons onto sensory spinal cord neurons and inhibiting their activity and (2) indirectly by stimulating OT release from SON neurons into the periphery.
Beschreibung:Gesehen am 13.05.2019
Beschreibung:Online Resource
ISSN:1097-4199
DOI:10.1016/j.neuron.2016.01.041

Ähnliche Einträge