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Acute canagliflozin treatment protects against in vivo myocardial ischemia–reperfusion injury in non-diabetic male rats and enhances endothelium-dependent vasorelaxation

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The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease in hospitalization for heart failure (HF) especially in those with HF at baseline. These might indicate a potent direct card...

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Bibliographische Detailangaben
Hauptverfasser: Sayour, Alex Ali (VerfasserIn) , Korkmaz-İçöz, Sevil (VerfasserIn) , Loganathan, Sivakkanan (VerfasserIn) , Ruppert, Mihály (VerfasserIn) , Brune, Maik (VerfasserIn) , Karck, Matthias (VerfasserIn) , Szabó, Gábor (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 16 April 2019
In: Journal of translational medicine
Year: 2019, Jahrgang: 17, Pages: 1-14
ISSN:1479-5876
DOI:10.1186/s12967-019-1881-8
Online-Zugang:Verlag, Volltext: https://doi.org/10.1186/s12967-019-1881-8
Volltext
Verfasserangaben:Alex Ali Sayour, Sevil Korkmaz-Icöz, Sivakkanan Loganathan, Mihály Ruppert, Viktor Nabil Sayour, Attila Oláh, Kálmán Benke, Maik Brune, Rita Benkő, Eszter Mária Horváth, Matthias Karck, Béla Merkely, Tamás Radovits and Gábor Szabó
Beschreibung
Zusammenfassung:The sodium–glucose cotransporter-2 (SGLT2) inhibitor canagliflozin has been shown to reduce major cardiovascular events in type 2 diabetic patients, with a pronounced decrease in hospitalization for heart failure (HF) especially in those with HF at baseline. These might indicate a potent direct cardioprotective effect, which is currently incompletely understood. We sought to characterize the cardiovascular effects of acute canagliflozin treatment in healthy and infarcted rat hearts.
Beschreibung:Gesehen am 14.05.2019
Beschreibung:Online Resource
ISSN:1479-5876
DOI:10.1186/s12967-019-1881-8

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