Actively personalized vaccination trial for newly diagnosed glioblastoma

In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8+ and CD4+ T cells, respectively, in patients with newly diagnosed glioblastoma.

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Bibliographic Details
Main Authors:	Hilf, Norbert (Author) , Platten, Michael (Author) , Deimling, Andreas von (Author) , Bunse, Lukas (Author) , Wick, Wolfgang (Author) , Capper, David (Author)
Format:	Article (Journal) Editorial
Language:	English
Published:	2019
In:	Nature Year: 2019, Volume: 565, Issue: 7738, Pages: 240-245
ISSN:	1476-4687
DOI:	10.1038/s41586-018-0810-y
Online Access:	Verlag, Volltext: https://doi.org/10.1038/s41586-018-0810-y Verlag, Volltext: https://www.nature.com/articles/s41586-018-0810-y
Author Notes:	Norbert Hilf, Sabrina Kuttruff-Coqui, Katrin Frenzel, Valesca Bukur, Stefan Stevanović, Cécile Gouttefangeas, Michael Platten, Ghazaleh Tabatabai, Valerie Dutoit, Sjoerd H. van der Burg, Per thor Straten, Francisco Martínez-Ricarte, Berta Ponsati, Hideho Okada, Ulrik Lassen, Arie Admon, Christian H. Ottensmeier, Alexander Ulges, Sebastian Kreiter, Andreas von Deimling, Marco Skardelly, Denis Migliorini, Judith R. Kroep, Manja Idorn, Jordi Rodon, Jordi Piró, Hans S. Poulsen, Bracha Shraibman, Katy McCann, Regina Mendrzyk, Martin Löwer, Monika Stieglbauer, Cedrik M. Britten, David Capper, Marij J. P. Welters, Juan Sahuquillo, Katharina Kiesel, Evelyna Derhovanessian, Elisa Rusch, Lukas Bunse, Colette Song, Sandra Heesch, Claudia Wagner, Alexandra Kemmer-Brück, Jörg Ludwig, John C. Castle, Oliver Schoor, Arbel D. Tadmor, Edward Green, Jens Fritsche, Miriam Meyer, Nina Pawlowski, Sonja Dorner, Franziska Hoffgaard, Bernhard Rössler, Dominik Maurer, Toni Weinschenk, Carsten Reinhardt, Christoph Huber, Hans-Georg Rammensee, Harpreet Singh-Jasuja, Ugur Sahin, Pierre-Yves Dietrich & Wolfgang Wick

Description
Summary:	In a phase I trial, highly individualized peptide vaccines against unmutated tumour antigens and neoepitopes elicited sustained responses in CD8+ and CD4+ T cells, respectively, in patients with newly diagnosed glioblastoma.
Item Description:	Published online 19 December 2018 Gesehen am 14.05.2019
Physical Description:	Online Resource
ISSN:	1476-4687
DOI:	10.1038/s41586-018-0810-y