Buchumschlag

Unizentrische, retrospektive Analyse der praktischen Durchführung der extrakorporalen Photopherese: periphervenöser und zentralvenöser Zugang im Vergleich = Single-center retrospective analysis of extracorporal photopheresis in clinical practice : peripheral venous compared to central venous access

BackgroundExtracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.MethodsTreatment protocols of 2038 ECP proc...

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Bibliographische Detailangaben
Hauptverfasser: Hambsch, Jasmin (VerfasserIn) , Büttner, Sylvia (VerfasserIn) , Nicolay, Jan Peter (VerfasserIn) , Felcht, Moritz (VerfasserIn) , Booken, Nina (VerfasserIn) , Klemke, Claus-Detlev (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Deutsch
Veröffentlicht: 9. Januar 2019
In: Der Hautarzt
Year: 2019, Jahrgang: 70, Heft: 3, Pages: 193-203
ISSN:1432-1173
DOI:10.1007/s00105-018-4327-y
Online-Zugang:Verlag, Volltext: https://doi.org/10.1007/s00105-018-4327-y
Volltext
Verfasserangaben:Jasmin Hambsch, Sylvia Büttner, Markus Heck, Jan P. Nicolay, Moritz Felcht, Nina Booken, Claus-Detlev Klemke
Beschreibung
Zusammenfassung:BackgroundExtracorporal photopheresis (ECP) was shown to be effective without severe side effects in the treatment of cutaneous T cell lymphoma (CTCL) and graft versus host disease (GvHD). However, only few studies investigated the practical aspects of ECP.MethodsTreatment protocols of 2038 ECP procedures in 52 patients (CTCL, n = 29; GvHD, n = 15; other, n = 8) were evaluated. The patients were treated with the UVAR® XTS™ ECP system (Therakos, Inc. Johnson & Johnson, Raritan, NJ, USA) between 2001 and 2010. All patients started with a peripheral venous access. During the course of treatment 7 patients were treated via a port and 4 via a central venous catheter.ResultsIn all, 1765 (86.6%) treatments were performed with a peripheral venous access; 239 (11.7%) ECPs were done via a port and 34 (1.7%) via a central venous catheter. The peripheral venous access showed a higher flow rate and longer photoactivation time. ECPs via port lead to higher UV-irradiated volumes, longer treatment times and higher differences in systolic blood pressure. The following side effects were observed: being unwell (n = 13), hypo- (n = 13) and hypertension (n = 7), vertigo (n = 4), headache (n = 4), shortness of breath (n = 4), fever (n = 3) and metallic taste (n = 3). Technical complications such as problems with venous access (9.6%) occurred in 385 (18.9%) treatments.ConclusionsPeripheral venous access should be preferred for ECP treatments.
Beschreibung:Gesehen am 14.05.2019
Beschreibung:Online Resource
ISSN:1432-1173
DOI:10.1007/s00105-018-4327-y

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