A new bronchoscopic catheter for the transbronchial ablation of pulmonary nodules
Objectives - With the objective of simultaneous bronchoscopic biopsy and ablation of malignant solitary pulmonary nodules, we have developed a flexible monopolar radiofrequency (RF) catheter that can be deployed through the working channel of most bronchoscopes. - Materials and Methods - Fresh tumor...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
26 July 2018
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| In: |
Lung cancer
Year: 2018, Volume: 124, Pages: 125-129 |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2018.07.038 |
| Online Access: | Verlag, Volltext: https://doi.org/10.1016/j.lungcan.2018.07.038 Verlag, Volltext: http://www.sciencedirect.com/science/article/pii/S0169500218304999 
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| Author Notes: | Seyer Safi, Jan op den Winkel, Steve Kramer, Thomas Keast, Henky Wibowo, Thomas Muley, Felix J.F. Herth |
| Summary: | Objectives - With the objective of simultaneous bronchoscopic biopsy and ablation of malignant solitary pulmonary nodules, we have developed a flexible monopolar radiofrequency (RF) catheter that can be deployed through the working channel of most bronchoscopes. - Materials and Methods - Fresh tumor specimens were heated in a water bath to 37 °C, and the RF catheter was inserted into the tumors within the specimen. Temperature sensors were positioned 3 mm, 5 mm and 7 mm from the electrode to measure the temperature of the surrounding tissue every 1 s. The ablation was conducted by applying RF energy for 8 min. The ablated specimens were evaluated by cutting the tissue samples along the top of the device and measuring the ablation zones. - Results - Five ablations were performed in 3 specimens. All of the ablation zones had a major axis length (along the electrode axis) between 18.9 mm and 22.8 mm and a minor axis length (perpendicular to the major axis) between 13.3 mm and 18.0 mm. The temperature data showed that all of the temperature sensors detected 60 °C or higher. These results demonstrate that the RF catheter was capable of generating ablation zones that were locally contained in ex vivo human cancerous lung specimens and that incorporated the tumor tissues. - Conclusion - We present the results of a benchtop study demonstrating the local control of ablation achieved using the RF device. This study suggests that the ex vivo ablation of lung malignancy with a new bronchoscopic RF catheter is feasible and that in vivo tumor ablation with this method in humans merits further study. |
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| Item Description: | Gesehen am 14.05.2019 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8332 |
| DOI: | 10.1016/j.lungcan.2018.07.038 |