SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models
Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here, we show that endogen...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
11 January 2019
|
| In: |
Disease models & mechanisms
Year: 2019, Jahrgang: 12, Heft: 1, Pages: 1-16 |
| ISSN: | 1754-8411 |
| DOI: | 10.1242/dmm.036145 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.1242/dmm.036145 Verlag, Volltext: http://dmm.biologists.org/content/12/1/dmm036145 
|
| Verfasserangaben: | Martina Marinello, Andreas Werner, Mariagiovanna Giannone, Khadija Tahiri, Sandro Alves, Christelle Tesson, Wilfred den Dunnen, Jacob-S. Seeler, Alexis Brice and Annie Sittler |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1665812435 | ||
| 003 | DE-627 | ||
| 005 | 20231205124553.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190516s2019 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1242/dmm.036145 |2 doi | |
| 035 | |a (DE-627)1665812435 | ||
| 035 | |a (DE-599)KXP1665812435 | ||
| 035 | |a (OCoLC)1341224745 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Marinello, Martina |e VerfasserIn |0 (DE-588)1186295961 |0 (DE-627)1665815086 |4 aut | |
| 245 | 1 | 0 | |a SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models |c Martina Marinello, Andreas Werner, Mariagiovanna Giannone, Khadija Tahiri, Sandro Alves, Christelle Tesson, Wilfred den Dunnen, Jacob-S. Seeler, Alexis Brice and Annie Sittler |
| 264 | 1 | |c 11 January 2019 | |
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 16.05.2019 | ||
| 520 | |a Perturbation of protein homeostasis and aggregation of misfolded proteins is a major cause of many human diseases. A hallmark of the neurodegenerative disease spinocerebellar ataxia type 7 (SCA7) is the intranuclear accumulation of mutant, misfolded ataxin-7 (polyQ-ATXN7). Here, we show that endogenous ATXN7 is modified by SUMO proteins, thus also suggesting a physiological role for this modification under conditions of proteotoxic stress caused by the accumulation of polyQ-ATXN7. Co-immunoprecipitation experiments, immunofluorescence microscopy and proximity ligation assays confirmed the colocalization and interaction of polyQ-ATXN7 with SUMO2 in cells. ... | ||
| 700 | 1 | |a Werner, Andreas |d 1971- |e VerfasserIn |0 (DE-588)123719046 |0 (DE-627)706405927 |0 (DE-576)293843058 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Disease models & mechanisms |d Cambridge : Company of Biologists Limited, 2008 |g 12(2019), 1, Artikel-ID dmm036145, Seite 1-16 |h Online-Ressource |w (DE-627)578531917 |w (DE-600)2451104-3 |w (DE-576)335783058 |x 1754-8411 |7 nnas |a SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models |
| 773 | 1 | 8 | |g volume:12 |g year:2019 |g number:1 |g elocationid:dmm036145 |g pages:1-16 |g extent:16 |a SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models |
| 856 | 4 | 0 | |u https://doi.org/10.1242/dmm.036145 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://dmm.biologists.org/content/12/1/dmm036145 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190516 | ||
| 993 | |a Article | ||
| 994 | |a 2019 | ||
| 998 | |g 123719046 |a Werner, Andreas |m 123719046:Werner, Andreas |p 2 | ||
| 999 | |a KXP-PPN1665812435 |e 3476512673 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 16.05.2019"],"recId":"1665812435","language":["eng"],"person":[{"roleDisplay":"VerfasserIn","display":"Marinello, Martina","role":"aut","family":"Marinello","given":"Martina"},{"given":"Andreas","family":"Werner","role":"aut","display":"Werner, Andreas","roleDisplay":"VerfasserIn"}],"title":[{"title":"SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models","title_sort":"SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models"}],"physDesc":[{"extent":"16 S."}],"relHost":[{"name":{"displayForm":["publ. for the Company of Biologists Limited"]},"origin":[{"dateIssuedDisp":"2008-","dateIssuedKey":"2008","publisher":"Company of Biologists Limited","publisherPlace":"Cambridge"}],"id":{"eki":["578531917"],"zdb":["2451104-3"],"issn":["1754-8411"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Disease models & mechanisms","subtitle":"DMM","title_sort":"Disease models & mechanisms"}],"disp":"SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 modelsDisease models & mechanisms","note":["Gesehen am 21.04.2021"],"type":{"bibl":"periodical","media":"Online-Ressource"},"recId":"578531917","corporate":[{"role":"isb","display":"The Company of Biologists","roleDisplay":"Herausgebendes Organ"}],"language":["eng"],"pubHistory":["1.2008 -"],"titleAlt":[{"title":"DMM"}],"part":{"volume":"12","text":"12(2019), 1, Artikel-ID dmm036145, Seite 1-16","extent":"16","year":"2019","pages":"1-16","issue":"1"}}],"name":{"displayForm":["Martina Marinello, Andreas Werner, Mariagiovanna Giannone, Khadija Tahiri, Sandro Alves, Christelle Tesson, Wilfred den Dunnen, Jacob-S. Seeler, Alexis Brice and Annie Sittler"]},"origin":[{"dateIssuedKey":"2019","dateIssuedDisp":"11 January 2019"}],"id":{"doi":["10.1242/dmm.036145"],"eki":["1665812435"]}} | ||
| SRT | |a MARINELLOMSUMOYLATIO1120 | ||