High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro
The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. Eighty-six subjects were divided into me...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 April 2018
|
| In: |
Journal of immunology research
Year: 2018, Pages: 2737040 |
| ISSN: | 2314-7156 |
| DOI: | undefined |
| Online-Zugang: | Verlag, Volltext: https://doi.org/undefined Verlag, Volltext: https://www.hindawi.com/journals/jir/2018/2737040/ 
|
| Verfasserangaben: | Johanna L. Grün, Aaron N. Manjarrez-Reyna, Angélica Y. Gómez-Arauz, Sonia Leon-Cabrera, Felix Rückert, José M. Fragoso, Nallely Bueno-Hernández, Sergio Islas-Andrade, Guillermo Meléndez-Mier, and Galileo Escobedo |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1665942495 | ||
| 003 | DE-627 | ||
| 005 | 20240314145611.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190520s2018 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1665942495 | ||
| 035 | |a (DE-599)KXP1665942495 | ||
| 035 | |a (OCoLC)1341225056 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Betzler, Johanna |d 1992- |e VerfasserIn |0 (DE-588)1158701705 |0 (DE-627)1020784873 |0 (DE-576)504340824 |4 aut | |
| 245 | 1 | 0 | |a High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro |c Johanna L. Grün, Aaron N. Manjarrez-Reyna, Angélica Y. Gómez-Arauz, Sonia Leon-Cabrera, Felix Rückert, José M. Fragoso, Nallely Bueno-Hernández, Sergio Islas-Andrade, Guillermo Meléndez-Mier, and Galileo Escobedo |
| 264 | 1 | |c 3 April 2018 | |
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 20.05.2019 | ||
| 520 | |a The effect of metabolic syndrome on human monocyte subpopulations has not yet been studied. Our main goal was to examine monocyte subpopulations in metabolic syndrome patients, while also identifying the risk factors that could directly influence these cells. Eighty-six subjects were divided into metabolic syndrome patients and controls. Monocyte subpopulations were quantified by flow cytometry, and interleukin- (IL-) 1β secretion levels were measured by ELISA. Primary human monocytes were cultured in low or elevated concentrations of high-density lipoprotein (HDL) and stimulated with lipopolysaccharide (LPS). The nonclassical monocyte (NCM) percentage was significantly increased in metabolic syndrome patients as compared to controls, whereas classical monocytes (CM) were reduced. Among all metabolic syndrome risk factors, HDL reduction exhibited the most important correlation with monocyte subpopulations and then was studied in vitro. Low HDL concentration reduced the CM percentage, whereas it increased the NCM percentage and IL-1β secretion in LPS-treated monocytes. The LPS effect was abolished when monocytes were cultured in elevated HDL concentrations. Concurring with in vitro results, IL-1β serum values significantly increased in metabolic syndrome patients with low HDL levels as compared to metabolic syndrome patients without HDL reduction. Our data demonstrate that HDL directly modulates monocyte subpopulations in metabolic syndrome. | ||
| 700 | 1 | |a Rückert, Felix |d 1978- |e VerfasserIn |0 (DE-588)130606332 |0 (DE-627)504638017 |0 (DE-576)298294230 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of immunology research |d [Hoboken, NJ] : Wiley, 2014 |g 2018, Artikel-Nummer 2737040, 12 Seiten |h Online-Ressource |w (DE-627)821910469 |w (DE-600)2817541-4 |w (DE-576)429186746 |x 2314-7156 |7 nnas |a High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro |
| 773 | 1 | 8 | |g year:2018 |g pages:2737040 |g extent:12 |a High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro |
| 856 | 4 | 0 | |u https://doi.org/undefined |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u https://www.hindawi.com/journals/jir/2018/2737040/ |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190520 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 130606332 |a Rückert, Felix |m 130606332:Rückert, Felix |d 60000 |d 61800 |e 60000PR130606332 |e 61800PR130606332 |k 0/60000/ |k 1/60000/61800/ |p 5 | ||
| 998 | |g 1158701705 |a Betzler, Johanna |m 1158701705:Betzler, Johanna |d 60000 |e 60000PB1158701705 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1665942495 |e 3478293073 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1665942495","note":["Gesehen am 20.05.2019"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro","title_sort":"High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitro"}],"language":["eng"],"person":[{"roleDisplay":"VerfasserIn","role":"aut","given":"Johanna","display":"Betzler, Johanna","family":"Betzler"},{"family":"Rückert","role":"aut","roleDisplay":"VerfasserIn","given":"Felix","display":"Rückert, Felix"}],"relHost":[{"part":{"text":"2018, Artikel-Nummer 2737040, 12 Seiten","extent":"12","year":"2018","pages":"2737040"},"recId":"821910469","note":["Gesehen am 04.04.2025"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["Volume 2014-"],"id":{"issn":["2314-7156"],"zdb":["2817541-4"],"eki":["821910469"]},"title":[{"title_sort":"Journal of immunology research","title":"Journal of immunology research"}],"disp":"High-density lipoprotein reduction differentially modulates to classical and nonclassical monocyte subpopulations in metabolic syndrome patients and in LPS-stimulated primary human monocytes in vitroJournal of immunology research","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedKey":"2024","publisherPlace":"[Hoboken, NJ] ; New York, NY","dateIssuedDisp":"2024-","publisher":"Wiley ; Hindawi"}]}],"origin":[{"dateIssuedKey":"2018","dateIssuedDisp":"3 April 2018"}],"name":{"displayForm":["Johanna L. Grün, Aaron N. Manjarrez-Reyna, Angélica Y. Gómez-Arauz, Sonia Leon-Cabrera, Felix Rückert, José M. Fragoso, Nallely Bueno-Hernández, Sergio Islas-Andrade, Guillermo Meléndez-Mier, and Galileo Escobedo"]},"id":{"eki":["1665942495"]},"physDesc":[{"extent":"12 S."}]} | ||
| SRT | |a BETZLERJOHHIGHDENSIT3201 | ||