Shift of keratin expression profile in end-stage kidney increases the risk of tumor development
Background/Aim: Pre-neoplastic lesions and renal cell tumors of distinct pheno- and genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the role of KRT7 and KRT19 in this process, the expression of which was previously detected by Affymetrix GeneChip analysis. P...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
17 July 2018
|
| In: |
Anticancer research
Year: 2018, Jahrgang: 38, Heft: 9, Pages: 5217-5222 |
| ISSN: | 1791-7530 |
| DOI: | 10.21873/anticanres.12845 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.21873/anticanres.12845 Verlag, Volltext: http://ar.iiarjournals.org/content/38/9/5217 
|
| Verfasserangaben: | Donat Peter Sarlos, Lehel Peterfi, Arpad Szanto and Gyula Kovacs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 166599861X | ||
| 003 | DE-627 | ||
| 005 | 20230427160317.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 190521s2018 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21873/anticanres.12845 |2 doi | |
| 035 | |a (DE-627)166599861X | ||
| 035 | |a (DE-599)KXP166599861X | ||
| 035 | |a (OCoLC)1341224803 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sarlós, Donát Péter |e VerfasserIn |0 (DE-588)1186723319 |0 (DE-627)1665992840 |4 aut | |
| 245 | 1 | 0 | |a Shift of keratin expression profile in end-stage kidney increases the risk of tumor development |c Donat Peter Sarlos, Lehel Peterfi, Arpad Szanto and Gyula Kovacs |
| 264 | 1 | |c 17 July 2018 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 21.05.2019 | ||
| 520 | |a Background/Aim: Pre-neoplastic lesions and renal cell tumors of distinct pheno- and genotypes occur frequently in end-stage kidneys. The aim of this study was to investigate the role of KRT7 and KRT19 in this process, the expression of which was previously detected by Affymetrix GeneChip analysis. Patients and Methods: Twelve end-stage kidneys were analyzed to find pre-neoplastic lesions and tumors and expression of KRT7 and KRT19 was examined by immunohistochemistry. Results: A total of 17 tumors, 149 pre-neoplastic lesions, 179 simple or proliferative cysts >2 mm were identified. Diffuse expression of KRT7 and KRT19 was seen in all end-stage kidneys as well as in the vast majority of cysts, pre-neoplastic lesions and tumors. Conclusion: Our data indicates that de novo expression of KRT7 and KRT19 resulting in altered plasticity and stem cell characteristics of epithelial cells might be a crucial factor in increasing the risk of tumor development in end-stage kidneys. | ||
| 650 | 4 | |a End-stage renal disease | |
| 650 | 4 | |a immunohistochemistry | |
| 650 | 4 | |a KRT19 | |
| 650 | 4 | |a KRT7 | |
| 650 | 4 | |a tumor development | |
| 700 | 1 | |a Kovacs, Gyula |e VerfasserIn |0 (DE-588)1081747579 |0 (DE-627)846587424 |0 (DE-576)454756399 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Anticancer research |d Kapandriti, Attiki, Greece : International Institute of Anticancer Research, 2004 |g 38(2018), 9, Seite 5217-5222 |h Online-Ressource |w (DE-627)387478493 |w (DE-600)2145376-7 |w (DE-576)358408717 |x 1791-7530 |7 nnas |a Shift of keratin expression profile in end-stage kidney increases the risk of tumor development |
| 773 | 1 | 8 | |g volume:38 |g year:2018 |g number:9 |g pages:5217-5222 |g extent:6 |a Shift of keratin expression profile in end-stage kidney increases the risk of tumor development |
| 856 | 4 | 0 | |u https://doi.org/10.21873/anticanres.12845 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://ar.iiarjournals.org/content/38/9/5217 |x Verlag |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20190521 | ||
| 993 | |a Article | ||
| 994 | |a 2018 | ||
| 998 | |g 1081747579 |a Kovacs, Gyula |m 1081747579:Kovacs, Gyula |d 910000 |d 910200 |e 910000PK1081747579 |e 910200PK1081747579 |k 0/910000/ |k 1/910000/910200/ |p 4 |y j | ||
| 999 | |a KXP-PPN166599861X |e 3478574056 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"166599861X","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 21.05.2019"],"person":[{"role":"aut","roleDisplay":"VerfasserIn","display":"Sarlós, Donát Péter","given":"Donát Péter","family":"Sarlós"},{"display":"Kovacs, Gyula","roleDisplay":"VerfasserIn","role":"aut","family":"Kovacs","given":"Gyula"}],"title":[{"title_sort":"Shift of keratin expression profile in end-stage kidney increases the risk of tumor development","title":"Shift of keratin expression profile in end-stage kidney increases the risk of tumor development"}],"relHost":[{"title":[{"title_sort":"Anticancer research","subtitle":"international journal of cancer research and treatment","title":"Anticancer research"}],"recId":"387478493","language":["eng"],"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Shift of keratin expression profile in end-stage kidney increases the risk of tumor developmentAnticancer research","note":["Gesehen am 26.02.13"],"part":{"pages":"5217-5222","issue":"9","year":"2018","extent":"6","text":"38(2018), 9, Seite 5217-5222","volume":"38"},"pubHistory":["Nachgewiesen 24.2004 -"],"name":{"displayForm":["International Institute of Anticancer Research"]},"id":{"issn":["1791-7530"],"eki":["387478493"],"zdb":["2145376-7"]},"origin":[{"dateIssuedKey":"2004","publisher":"International Institute of Anticancer Research","dateIssuedDisp":"2004-","publisherPlace":"Kapandriti, Attiki, Greece"}],"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"6 S."}],"name":{"displayForm":["Donat Peter Sarlos, Lehel Peterfi, Arpad Szanto and Gyula Kovacs"]},"id":{"doi":["10.21873/anticanres.12845"],"eki":["166599861X"]},"origin":[{"dateIssuedDisp":"17 July 2018","dateIssuedKey":"2018"}]} | ||
| SRT | |a SARLOSDONASHIFTOFKER1720 | ||