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Cancer cells invade confined microchannels via a self-directed mesenchymal-to-amoeboid transition

Cancer cell invasion through physical barriers in the extracellular matrix (ECM) requires a complex synergy of traction force against the ECM, mechanosensitive feedback, and subsequent cytoskeletal rearrangement. PDMS microchannels were used to investigate the transition from mesenchymal to amoeboid...

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Hauptverfasser: Holle, Andrew W. (VerfasserIn) , Spatz, Joachim P. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: February 18, 2019
In: Nano letters
Year: 2019, Jahrgang: 19, Heft: 4, Pages: 2280-2290
ISSN:1530-6992
DOI:10.1021/acs.nanolett.8b04720
Online-Zugang:Verlag, Volltext: https://doi.org/10.1021/acs.nanolett.8b04720
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Verfasserangaben:Andrew W. Holle, Neethu Govindan Kutty Devi, Kim Clar, Anthony Fan, Taher Saif, Ralf Kemkemer, and Joachim P. Spatz

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