Attenuation of novelty-induced hyperactivity of gria1-/- mice by cannabidiol and hippocampal inhibitory chemogenetics
Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them to constitute a model for hyperactivity disorders such as mania, schizophrenia and attention deficit hyperactivity disorder. This behavioral alteration h...
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| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
29 March 2019
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| In: |
Frontiers in pharmacology
Year: 2019, Jahrgang: 10 |
| ISSN: | 1663-9812 |
| DOI: | 10.3389/fphar.2019.00309 |
| Online-Zugang: | Verlag, Volltext: https://doi.org/10.3389/fphar.2019.00309 Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fphar.2019.00309/full 
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| Verfasserangaben: | Teemu Aitta-aho, Milica Maksimovic, Kristiina Dahl, Rolf Sprengel and Esa R. Korpi |
MARC
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| 245 | 1 | 0 | |a Attenuation of novelty-induced hyperactivity of gria1-/- mice by cannabidiol and hippocampal inhibitory chemogenetics |c Teemu Aitta-aho, Milica Maksimovic, Kristiina Dahl, Rolf Sprengel and Esa R. Korpi |
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| 520 | |a Gene-targeted mice with deficient AMPA receptor GluA1 subunits (Gria1-/- mice) show robust hyperlocomotion in a novel environment, suggesting them to constitute a model for hyperactivity disorders such as mania, schizophrenia and attention deficit hyperactivity disorder. This behavioral alteration has been associated with increased neuronal activation in the hippocampus, and it can be attenuated by chronic treatment with antimanic drugs, such as lithium, valproic acid and lamotrigine. Now we found that systemic cannabidiol strongly blunted the hyperactivity and the hippocampal c-Fos expression of the Gria1-/- mice, while not affecting the wildtype littermate controls. Acute bilateral intra-dorsal hippocampal infusion of cannabidiol partially blocked the hyperactivity of the Gria1-/- mice, but had no effect on wildtypes. The activation of the inhibitory DREADD receptor hM4Gi in the dorsal hippocampus by clozapine-N-oxide robustly inhibited the hyperactivity of the Gria1-/- mice, but had no effect on the locomotion of wildtype mice. Our results show that enhanced neuronal excitability in the hippocampus is associated with pronounced novelty-induced hyperactivity of GluA1 subunit-deficient mice. When this enhanced response of hippocampal neurons to novel stimuli is specifically reduced in the hippocampus by pharmacological treatment or by chemogenetic inhibition, Gria1-/- mice recover from behavioral hyperactivity, suggesting a hippocampal dysfunction in hyperactive behaviors that can be treated with cannabidiol. | ||
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| 650 | 4 | |a Cannabidiol (CBD) | |
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