Buchumschlag

Subcellular localization of sprouty2 in human glioma cells

Sprouty proteins act ubiquitously as signaling integrators and inhibitors of receptor tyrosine kinase activated pathways. Among the four Sprouty isoforms, Sprouty2 is a key regulator of growth factor signaling in several neurological disorders. High protein levels correlate with reduced survival of...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Hausott, Barbara (VerfasserIn) , Park, Jongwhi (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 March 2019
In: Frontiers in molecular neuroscience
Year: 2019, Jahrgang: 12
ISSN:1662-5099
DOI:10.3389/fnmol.2019.00073
Online-Zugang:Verlag, Volltext: https://doi.org/10.3389/fnmol.2019.00073
Verlag, Volltext: https://www.frontiersin.org/articles/10.3389/fnmol.2019.00073/full
Volltext
Verfasserangaben:Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley and Lars Klimaschewski

MARC

LEADER 00000caa a2200000 c 4500
001 1666088005
003 DE-627
005 20220816155654.0
007 cr uuu---uuuuu
008 190522s2019 xx |||||o 00| ||eng c
024 7 |a 10.3389/fnmol.2019.00073  |2 doi 
035 |a (DE-627)1666088005 
035 |a (DE-599)KXP1666088005 
035 |a (OCoLC)1341224892 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Hausott, Barbara  |d 1973-  |e VerfasserIn  |0 (DE-588)1186819278  |0 (DE-627)1666088552  |4 aut 
245 1 0 |a Subcellular localization of sprouty2 in human glioma cells  |c Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley and Lars Klimaschewski 
264 1 |c 29 March 2019 
300 |b Illustrationen 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 22.05.2019 
520 |a Sprouty proteins act ubiquitously as signaling integrators and inhibitors of receptor tyrosine kinase activated pathways. Among the four Sprouty isoforms, Sprouty2 is a key regulator of growth factor signaling in several neurological disorders. High protein levels correlate with reduced survival of glioma patients. We recently demonstrated that abrogating its function inhibits tumor growth by overstimulation of ERK and induction of DNA replication stress. The important role of Sprouty2 in proliferation of malignant glioma cells prompted us to investigate its subcellular localization applying super-resolution fluorescence and immuno-electronmicroscopy. We found that cytoplasmic Sprouty2 is not homogenously distributed but localized to small spots (< 100 nm) partly attached to vimentin filaments and co-localized with activated ERK. The protein is associated with early, late and recycling endosomes in response to but also independently of growth factor stimulation. The subcellular localization of Sprouty2 in all areas exhibiting strong receptor tyrosine kinase activities may reflect a protective response of glioma cells to limit excessive ERK activation and to prevent cellular senescence and apoptosis. 
650 4 |a Cytoskeleton 
650 4 |a Electronmicroscopy 
650 4 |a endosome 
650 4 |a ERK 
650 4 |a super-resolution 
650 4 |a Vimentin 
700 1 |a Park, Jongwhi  |e VerfasserIn  |0 (DE-588)1186818883  |0 (DE-627)1666087645  |4 aut 
773 0 8 |i Enthalten in  |t Frontiers in molecular neuroscience  |d Lausanne : Frontiers Research Foundation, 2008  |g Volume 12 (2019) Artikel-Nummer 73, Seite 1-11, 11 Seiten  |h Online-Ressource  |w (DE-627)579826449  |w (DE-600)2452967-9  |w (DE-576)286502267  |x 1662-5099  |7 nnas  |a Subcellular localization of sprouty2 in human glioma cells 
773 1 8 |g volume:12  |g year:2019  |g extent:11  |a Subcellular localization of sprouty2 in human glioma cells 
856 4 0 |u https://doi.org/10.3389/fnmol.2019.00073  |x Verlag  |x Resolving-System  |3 Volltext 
856 4 0 |u https://www.frontiersin.org/articles/10.3389/fnmol.2019.00073/full  |x Verlag  |3 Volltext 
951 |a AR 
992 |a 20190522 
993 |a Article 
994 |a 2019 
998 |g 1186818883  |a Park, Jongwhi  |m 1186818883:Park, Jongwhi  |d 910000  |d 911100  |e 910000PP1186818883  |e 911100PP1186818883  |k 0/910000/  |k 1/910000/911100/  |p 2 
999 |a KXP-PPN1666088005  |e 3478774179 
BIB |a Y 
SER |a journal 
JSO |a {"name":{"displayForm":["Barbara Hausott, Jong-Whi Park, Taras Valovka, Martin Offterdinger, Michael W. Hess, Stephan Geley and Lars Klimaschewski"]},"person":[{"family":"Hausott","roleDisplay":"VerfasserIn","role":"aut","given":"Barbara","display":"Hausott, Barbara"},{"family":"Park","roleDisplay":"VerfasserIn","role":"aut","given":"Jongwhi","display":"Park, Jongwhi"}],"title":[{"title_sort":"Subcellular localization of sprouty2 in human glioma cells","title":"Subcellular localization of sprouty2 in human glioma cells"}],"id":{"eki":["1666088005"],"doi":["10.3389/fnmol.2019.00073"]},"recId":"1666088005","language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"note":["Gesehen am 22.05.2019"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"relHost":[{"disp":"Subcellular localization of sprouty2 in human glioma cellsFrontiers in molecular neuroscience","title":[{"title":"Frontiers in molecular neuroscience","title_sort":"Frontiers in molecular neuroscience"}],"name":{"displayForm":["Frontiers Research Foundation"]},"origin":[{"dateIssuedDisp":"2008-","dateIssuedKey":"2008","publisherPlace":"Lausanne","publisher":"Frontiers Research Foundation"}],"pubHistory":["2008 -"],"part":{"volume":"12","extent":"11","text":"Volume 12 (2019) Artikel-Nummer 73, Seite 1-11, 11 Seiten","year":"2019"},"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 04.06.20"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"id":{"eki":["579826449"],"zdb":["2452967-9"],"issn":["1662-5099"]},"recId":"579826449"}],"origin":[{"dateIssuedDisp":"29 March 2019","dateIssuedKey":"2019"}]} 
SRT |a HAUSOTTBARSUBCELLULA2920 

Ähnliche Einträge